Kinetics of the hepatitis B core‐related antigen and treatment responses in chronic hepatitis B patients treated with tenofovir alafenamide Article Swipe
Norio Itokawa
,
Masanori Atsukawa
,
Akihito Tsubota
,
Toru Ishikawa
,
Hidenori Toyoda
,
Koichi Takaguchi
,
Tsunamasa Watanabe
,
Chikara Ogawa
,
Atsushi Hiraoka
,
Hironao Okubo
,
Haruki Uojima
,
Makoto Chuma
,
Akito Nozaki
,
Keizo Kato
,
Shigeru Mikami
,
Joji Tani
,
Asahiro Morishita
,
Toshifumi Tada
,
Toru Asano
,
Tomonori Senoh
,
Tsunekazu Oikawa
,
Tomomi Okubo
,
Takashi Kumada
,
Katsuhiko Iwakiri
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1111/hepr.14052
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1111/hepr.14052
Aim An association between hepatitis B core‐related antigen (HBcrAg) kinetics and hepatocarcinogenesis during nucleoside (t)id analog (NA) treatment has recently been reported. HBcrAg kinetics and factors associated with HBcrAg response during tenofovir alafenamide (TAF) administration remain unclear. In this multicenter retrospective study, we aimed to clarify the efficacy and safety of TAF in treatment‐naïve patients with chronic hepatitis B, focusing on the reduction in HBcrAg levels. Methods Patients were treated with TAF monotherapy for 96 weeks, and the kinetics of HBcrAg during treatment and the factors associated with HBcrAg response (defined as a change in HBcrAg of −1 log IU/mL from baseline) were evaluated. Results The study population comprised 241 patients, 36.9% of whom were HBeAg‐positive. The median baseline HBcrAg level was 4.7 log IU/mL. The median change in HBcrAg from baseline was −1.1 log IU/mL at 96 weeks after treatment. The HBcrAg response rate at 96 weeks was 56.6% (43/76). Multivariate analysis revealed high alanine transaminase level as an independent baseline factor associated with HBcrAg response at 96 weeks of treatment ( p = 4.53 × 10 −6 ). No correlation was found between the HBcrAg and hepatitis B surface antigen kinetics in patients treated with TAF monotherapy. Conclusions In TAF monotherapy for patients with chronic hepatitis B, HBcrAg levels were significantly decreased and baseline alanine transaminase level is an important factor associated with HBcrAg reduction. As no correlation was found between HBcrAg and reduced hepatitis B surface antigen levels in this study, HBcrAg kinetics in addition to hepatitis B surface antigen may need to be monitored during TAF treatment.
Related Topics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/hepr.14052
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/hepr.14052
- OA Status
- hybrid
- References
- 37
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4396496932
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4396496932Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1111/hepr.14052Digital Object Identifier
- Title
-
Kinetics of the hepatitis B core‐related antigen and treatment responses in chronic hepatitis B patients treated with tenofovir alafenamideWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-04-29Full publication date if available
- Authors
-
Norio Itokawa, Masanori Atsukawa, Akihito Tsubota, Toru Ishikawa, Hidenori Toyoda, Koichi Takaguchi, Tsunamasa Watanabe, Chikara Ogawa, Atsushi Hiraoka, Hironao Okubo, Haruki Uojima, Makoto Chuma, Akito Nozaki, Keizo Kato, Shigeru Mikami, Joji Tani, Asahiro Morishita, Toshifumi Tada, Toru Asano, Tomonori Senoh, Tsunekazu Oikawa, Tomomi Okubo, Takashi Kumada, Katsuhiko IwakiriList of authors in order
- Landing page
-
https://doi.org/10.1111/hepr.14052Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/hepr.14052Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/hepr.14052Direct OA link when available
- Concepts
-
Medicine, Chronic hepatitis, Hepatitis B, Internal medicine, Gastroenterology, Immunology, VirusTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
37Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4396496932 |
|---|---|
| doi | https://doi.org/10.1111/hepr.14052 |
| ids.doi | https://doi.org/10.1111/hepr.14052 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/38685853 |
| ids.openalex | https://openalex.org/W4396496932 |
| fwci | 0.0 |
| type | article |
| title | Kinetics of the hepatitis B core‐related antigen and treatment responses in chronic hepatitis B patients treated with tenofovir alafenamide |
| biblio.issue | 11 |
| biblio.volume | 54 |
| biblio.last_page | 1003 |
| biblio.first_page | 993 |
| topics[0].id | https://openalex.org/T10340 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 1.0 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2713 |
| topics[0].subfield.display_name | Epidemiology |
| topics[0].display_name | Hepatitis B Virus Studies |
| topics[1].id | https://openalex.org/T10151 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9993000030517578 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2721 |
| topics[1].subfield.display_name | Hepatology |
| topics[1].display_name | Hepatitis C virus research |
| topics[2].id | https://openalex.org/T10351 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.996999979019165 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2713 |
| topics[2].subfield.display_name | Epidemiology |
| topics[2].display_name | Liver Disease Diagnosis and Treatment |
| is_xpac | False |
| apc_list.value | 3400 |
| apc_list.currency | USD |
| apc_list.value_usd | 3400 |
| apc_paid.value | 3400 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 3400 |
| concepts[0].id | https://openalex.org/C71924100 |
| concepts[0].level | 0 |
| concepts[0].score | 0.7559828758239746 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[0].display_name | Medicine |
| concepts[1].id | https://openalex.org/C3020491458 |
| concepts[1].level | 3 |
| concepts[1].score | 0.5723843574523926 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q131742 |
| concepts[1].display_name | Chronic hepatitis |
| concepts[2].id | https://openalex.org/C2777382497 |
| concepts[2].level | 2 |
| concepts[2].score | 0.5080025792121887 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q6853 |
| concepts[2].display_name | Hepatitis B |
| concepts[3].id | https://openalex.org/C126322002 |
| concepts[3].level | 1 |
| concepts[3].score | 0.4870181679725647 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[3].display_name | Internal medicine |
| concepts[4].id | https://openalex.org/C90924648 |
| concepts[4].level | 1 |
| concepts[4].score | 0.43537116050720215 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q120569 |
| concepts[4].display_name | Gastroenterology |
| concepts[5].id | https://openalex.org/C203014093 |
| concepts[5].level | 1 |
| concepts[5].score | 0.20060032606124878 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q101929 |
| concepts[5].display_name | Immunology |
| concepts[6].id | https://openalex.org/C2522874641 |
| concepts[6].level | 2 |
| concepts[6].score | 0.08041000366210938 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q808 |
| concepts[6].display_name | Virus |
| keywords[0].id | https://openalex.org/keywords/medicine |
| keywords[0].score | 0.7559828758239746 |
| keywords[0].display_name | Medicine |
| keywords[1].id | https://openalex.org/keywords/chronic-hepatitis |
| keywords[1].score | 0.5723843574523926 |
| keywords[1].display_name | Chronic hepatitis |
| keywords[2].id | https://openalex.org/keywords/hepatitis-b |
| keywords[2].score | 0.5080025792121887 |
| keywords[2].display_name | Hepatitis B |
| keywords[3].id | https://openalex.org/keywords/internal-medicine |
| keywords[3].score | 0.4870181679725647 |
| keywords[3].display_name | Internal medicine |
| keywords[4].id | https://openalex.org/keywords/gastroenterology |
| keywords[4].score | 0.43537116050720215 |
| keywords[4].display_name | Gastroenterology |
| keywords[5].id | https://openalex.org/keywords/immunology |
| keywords[5].score | 0.20060032606124878 |
| keywords[5].display_name | Immunology |
| keywords[6].id | https://openalex.org/keywords/virus |
| keywords[6].score | 0.08041000366210938 |
| keywords[6].display_name | Virus |
| language | en |
| locations[0].id | doi:10.1111/hepr.14052 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S110399111 |
| locations[0].source.issn | 1386-6346, 1872-034X |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 1386-6346 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Hepatology Research |
| locations[0].source.host_organization | https://openalex.org/P4310320595 |
| locations[0].source.host_organization_name | Wiley |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320595 |
| locations[0].source.host_organization_lineage_names | Wiley |
| locations[0].license | cc-by-nc |
| locations[0].pdf_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/hepr.14052 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by-nc |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Hepatology Research |
| locations[0].landing_page_url | https://doi.org/10.1111/hepr.14052 |
| locations[1].id | pmid:38685853 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Hepatology research : the official journal of the Japan Society of Hepatology |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/38685853 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5009103376 |
| authorships[0].author.orcid | https://orcid.org/0009-0002-2390-6692 |
| authorships[0].author.display_name | Norio Itokawa |
| authorships[0].countries | JP |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I80188885 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Internal Medicine, Division of Gastroenterology and Hepatology, Nippon Medical School, Tokyo, Japan |
| authorships[0].institutions[0].id | https://openalex.org/I80188885 |
| authorships[0].institutions[0].ror | https://ror.org/00krab219 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I80188885 |
| authorships[0].institutions[0].country_code | JP |
| authorships[0].institutions[0].display_name | Nippon Medical School |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Norio Itokawa |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Internal Medicine, Division of Gastroenterology and Hepatology, Nippon Medical School, Tokyo, Japan |
| authorships[1].author.id | https://openalex.org/A5080709934 |
| authorships[1].author.orcid | https://orcid.org/0000-0003-3374-7111 |
| authorships[1].author.display_name | Masanori Atsukawa |
| authorships[1].countries | JP |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I80188885 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Internal Medicine, Division of Gastroenterology and Hepatology, Nippon Medical School, Tokyo, Japan |
| authorships[1].institutions[0].id | https://openalex.org/I80188885 |
| authorships[1].institutions[0].ror | https://ror.org/00krab219 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I80188885 |
| authorships[1].institutions[0].country_code | JP |
| authorships[1].institutions[0].display_name | Nippon Medical School |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Masanori Atsukawa |
| authorships[1].is_corresponding | True |
| authorships[1].raw_affiliation_strings | Department of Internal Medicine, Division of Gastroenterology and Hepatology, Nippon Medical School, Tokyo, Japan |
| authorships[2].author.id | https://openalex.org/A5086743926 |
| authorships[2].author.orcid | https://orcid.org/0000-0001-6860-0326 |
| authorships[2].author.display_name | Akihito Tsubota |
| authorships[2].countries | JP |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I115498069 |
| authorships[2].affiliations[0].raw_affiliation_string | Project Research Units (PRU) Research Center for Medical Science The Jikei University School of Medicine, Tokyo, Japan |
| authorships[2].institutions[0].id | https://openalex.org/I115498069 |
| authorships[2].institutions[0].ror | https://ror.org/039ygjf22 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I115498069 |
| authorships[2].institutions[0].country_code | JP |
| authorships[2].institutions[0].display_name | Jikei University School of Medicine |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Akihito Tsubota |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Project Research Units (PRU) Research Center for Medical Science The Jikei University School of Medicine, Tokyo, Japan |
| authorships[3].author.id | https://openalex.org/A5073095975 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-5470-9694 |
| authorships[3].author.display_name | Toru Ishikawa |
| authorships[3].countries | JP |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I4210108541 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Hepatology, Saiseikai Niigata Hospital, Niigata, Japan |
| authorships[3].institutions[0].id | https://openalex.org/I4210108541 |
| authorships[3].institutions[0].ror | https://ror.org/01mbdhx05 |
| authorships[3].institutions[0].type | healthcare |
| authorships[3].institutions[0].lineage | https://openalex.org/I4210108541 |
| authorships[3].institutions[0].country_code | JP |
| authorships[3].institutions[0].display_name | Saiseikai Niigata Daini Hospital |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Toru Ishikawa |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Hepatology, Saiseikai Niigata Hospital, Niigata, Japan |
| authorships[4].author.id | https://openalex.org/A5026964230 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-1652-6168 |
| authorships[4].author.display_name | Hidenori Toyoda |
| authorships[4].countries | JP |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I4210123703 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan |
| authorships[4].institutions[0].id | https://openalex.org/I4210123703 |
| authorships[4].institutions[0].ror | https://ror.org/0266t0867 |
| authorships[4].institutions[0].type | healthcare |
| authorships[4].institutions[0].lineage | https://openalex.org/I4210123703 |
| authorships[4].institutions[0].country_code | JP |
| authorships[4].institutions[0].display_name | Ogaki Municipal Hospital |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Hidenori Toyoda |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan |
| authorships[5].author.id | https://openalex.org/A5088307695 |
| authorships[5].author.orcid | https://orcid.org/0000-0003-0175-8721 |
| authorships[5].author.display_name | Koichi Takaguchi |
| authorships[5].countries | JP |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I4210153576 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Hepatology, Kagawa Prefectural Central Hospital, Takamatsu, Japan |
| authorships[5].institutions[0].id | https://openalex.org/I4210153576 |
| authorships[5].institutions[0].ror | https://ror.org/05m8dye22 |
| authorships[5].institutions[0].type | healthcare |
| authorships[5].institutions[0].lineage | https://openalex.org/I4210153576 |
| authorships[5].institutions[0].country_code | JP |
| authorships[5].institutions[0].display_name | Kagawa Prefectural Central Hospital |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Koichi Takaguchi |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Hepatology, Kagawa Prefectural Central Hospital, Takamatsu, Japan |
| authorships[6].author.id | https://openalex.org/A5086875352 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-7659-914X |
| authorships[6].author.display_name | Tsunamasa Watanabe |
| authorships[6].countries | JP |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I163917720 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan |
| authorships[6].institutions[0].id | https://openalex.org/I163917720 |
| authorships[6].institutions[0].ror | https://ror.org/043axf581 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I163917720 |
| authorships[6].institutions[0].country_code | JP |
| authorships[6].institutions[0].display_name | St. Marianna University School of Medicine |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Tsunamasa Watanabe |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan |
| authorships[7].author.id | https://openalex.org/A5062645991 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-4534-6692 |
| authorships[7].author.display_name | Chikara Ogawa |
| authorships[7].countries | JP |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I4210093795 |
| authorships[7].affiliations[0].raw_affiliation_string | Department of Gastroenterology and Hepatology, Takamatsu Red Cross Hospital, Takamatsu, Japan |
| authorships[7].institutions[0].id | https://openalex.org/I4210093795 |
| authorships[7].institutions[0].ror | https://ror.org/00n3egs77 |
| authorships[7].institutions[0].type | healthcare |
| authorships[7].institutions[0].lineage | https://openalex.org/I2799517759, https://openalex.org/I4210093795 |
| authorships[7].institutions[0].country_code | JP |
| authorships[7].institutions[0].display_name | Takamatsu Red Cross Hospital |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Chikara Ogawa |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Department of Gastroenterology and Hepatology, Takamatsu Red Cross Hospital, Takamatsu, Japan |
| authorships[8].author.id | https://openalex.org/A5040485741 |
| authorships[8].author.orcid | https://orcid.org/0000-0003-1989-0480 |
| authorships[8].author.display_name | Atsushi Hiraoka |
| authorships[8].countries | JP |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I4210145364 |
| authorships[8].affiliations[0].raw_affiliation_string | Gastroenterology Center, Ehime Prefectural Central Hospital, Matsuyama, Japan |
| authorships[8].institutions[0].id | https://openalex.org/I4210145364 |
| authorships[8].institutions[0].ror | https://ror.org/03c648b36 |
| authorships[8].institutions[0].type | healthcare |
| authorships[8].institutions[0].lineage | https://openalex.org/I4210145364 |
| authorships[8].institutions[0].country_code | JP |
| authorships[8].institutions[0].display_name | Ehime Prefectural Central Hospital |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Atsushi Hiraoka |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Gastroenterology Center, Ehime Prefectural Central Hospital, Matsuyama, Japan |
| authorships[9].author.id | https://openalex.org/A5086009195 |
| authorships[9].author.orcid | https://orcid.org/0000-0002-5995-199X |
| authorships[9].author.display_name | Hironao Okubo |
| authorships[9].countries | JP |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I4210164018 |
| authorships[9].affiliations[0].raw_affiliation_string | Department of Gastroenterology, Juntendo University Nerima Hospital, Tokyo, Japan |
| authorships[9].institutions[0].id | https://openalex.org/I4210164018 |
| authorships[9].institutions[0].ror | https://ror.org/05g1hyz84 |
| authorships[9].institutions[0].type | healthcare |
| authorships[9].institutions[0].lineage | https://openalex.org/I4210164018 |
| authorships[9].institutions[0].country_code | JP |
| authorships[9].institutions[0].display_name | Juntendo University Nerima Hospital |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Hironao Okubo |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Department of Gastroenterology, Juntendo University Nerima Hospital, Tokyo, Japan |
| authorships[10].author.id | https://openalex.org/A5084731951 |
| authorships[10].author.orcid | https://orcid.org/0000-0003-1719-1352 |
| authorships[10].author.display_name | Haruki Uojima |
| authorships[10].countries | JP |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I64189623 |
| authorships[10].affiliations[0].raw_affiliation_string | Department of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan |
| authorships[10].institutions[0].id | https://openalex.org/I64189623 |
| authorships[10].institutions[0].ror | https://ror.org/00f2txz25 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I64189623 |
| authorships[10].institutions[0].country_code | JP |
| authorships[10].institutions[0].display_name | Kitasato University |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Haruki Uojima |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Department of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan |
| authorships[11].author.id | https://openalex.org/A5028068047 |
| authorships[11].author.orcid | https://orcid.org/0000-0002-0963-9172 |
| authorships[11].author.display_name | Makoto Chuma |
| authorships[11].countries | JP |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I2802180866, https://openalex.org/I89630735 |
| authorships[11].affiliations[0].raw_affiliation_string | Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan |
| authorships[11].institutions[0].id | https://openalex.org/I89630735 |
| authorships[11].institutions[0].ror | https://ror.org/0135d1r83 |
| authorships[11].institutions[0].type | education |
| authorships[11].institutions[0].lineage | https://openalex.org/I89630735 |
| authorships[11].institutions[0].country_code | JP |
| authorships[11].institutions[0].display_name | Yokohama City University |
| authorships[11].institutions[1].id | https://openalex.org/I2802180866 |
| authorships[11].institutions[1].ror | https://ror.org/03k95ve17 |
| authorships[11].institutions[1].type | healthcare |
| authorships[11].institutions[1].lineage | https://openalex.org/I2802180866 |
| authorships[11].institutions[1].country_code | JP |
| authorships[11].institutions[1].display_name | Yokohama City University Medical Center |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Makoto Chuma |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan |
| authorships[12].author.id | https://openalex.org/A5079858903 |
| authorships[12].author.orcid | https://orcid.org/0000-0002-3310-6632 |
| authorships[12].author.display_name | Akito Nozaki |
| authorships[12].countries | JP |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I2802180866, https://openalex.org/I89630735 |
| authorships[12].affiliations[0].raw_affiliation_string | Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan |
| authorships[12].institutions[0].id | https://openalex.org/I89630735 |
| authorships[12].institutions[0].ror | https://ror.org/0135d1r83 |
| authorships[12].institutions[0].type | education |
| authorships[12].institutions[0].lineage | https://openalex.org/I89630735 |
| authorships[12].institutions[0].country_code | JP |
| authorships[12].institutions[0].display_name | Yokohama City University |
| authorships[12].institutions[1].id | https://openalex.org/I2802180866 |
| authorships[12].institutions[1].ror | https://ror.org/03k95ve17 |
| authorships[12].institutions[1].type | healthcare |
| authorships[12].institutions[1].lineage | https://openalex.org/I2802180866 |
| authorships[12].institutions[1].country_code | JP |
| authorships[12].institutions[1].display_name | Yokohama City University Medical Center |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Akito Nozaki |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan |
| authorships[13].author.id | https://openalex.org/A5101415226 |
| authorships[13].author.orcid | https://orcid.org/0000-0003-2184-6016 |
| authorships[13].author.display_name | Keizo Kato |
| authorships[13].countries | JP |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I4210137170 |
| authorships[13].affiliations[0].raw_affiliation_string | Division of Gastroenterology and Hepatology, Shinmatusdo Central General Hospital, Matsudo, Japan |
| authorships[13].institutions[0].id | https://openalex.org/I4210137170 |
| authorships[13].institutions[0].ror | https://ror.org/038estk42 |
| authorships[13].institutions[0].type | healthcare |
| authorships[13].institutions[0].lineage | https://openalex.org/I4210137170 |
| authorships[13].institutions[0].country_code | JP |
| authorships[13].institutions[0].display_name | Shinmatsudo Central General Hospital |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Keizo Kato |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | Division of Gastroenterology and Hepatology, Shinmatusdo Central General Hospital, Matsudo, Japan |
| authorships[14].author.id | https://openalex.org/A5051397464 |
| authorships[14].author.orcid | |
| authorships[14].author.display_name | Shigeru Mikami |
| authorships[14].countries | JP |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I13045471 |
| authorships[14].affiliations[0].raw_affiliation_string | Department of Internal Medicine, Division of Gastroenterology, Kikkoman General Hospital, Noda, Japan |
| authorships[14].institutions[0].id | https://openalex.org/I13045471 |
| authorships[14].institutions[0].ror | https://ror.org/00z0d6447 |
| authorships[14].institutions[0].type | company |
| authorships[14].institutions[0].lineage | https://openalex.org/I13045471 |
| authorships[14].institutions[0].country_code | JP |
| authorships[14].institutions[0].display_name | Kikkoman (Japan) |
| authorships[14].author_position | middle |
| authorships[14].raw_author_name | Shigeru Mikami |
| authorships[14].is_corresponding | False |
| authorships[14].raw_affiliation_strings | Department of Internal Medicine, Division of Gastroenterology, Kikkoman General Hospital, Noda, Japan |
| authorships[15].author.id | https://openalex.org/A5013902375 |
| authorships[15].author.orcid | https://orcid.org/0000-0001-8801-2505 |
| authorships[15].author.display_name | Joji Tani |
| authorships[15].countries | JP |
| authorships[15].affiliations[0].institution_ids | https://openalex.org/I201933988 |
| authorships[15].affiliations[0].raw_affiliation_string | Department of Gastroenterology, Kagawa University Graduate School of Medicine, Kagawa, Japan |
| authorships[15].institutions[0].id | https://openalex.org/I201933988 |
| authorships[15].institutions[0].ror | https://ror.org/04j7mzp05 |
| authorships[15].institutions[0].type | education |
| authorships[15].institutions[0].lineage | https://openalex.org/I201933988 |
| authorships[15].institutions[0].country_code | JP |
| authorships[15].institutions[0].display_name | Kagawa University |
| authorships[15].author_position | middle |
| authorships[15].raw_author_name | Joji Tani |
| authorships[15].is_corresponding | False |
| authorships[15].raw_affiliation_strings | Department of Gastroenterology, Kagawa University Graduate School of Medicine, Kagawa, Japan |
| authorships[16].author.id | https://openalex.org/A5085777607 |
| authorships[16].author.orcid | https://orcid.org/0000-0002-0760-3045 |
| authorships[16].author.display_name | Asahiro Morishita |
| authorships[16].countries | JP |
| authorships[16].affiliations[0].institution_ids | https://openalex.org/I201933988 |
| authorships[16].affiliations[0].raw_affiliation_string | Department of Gastroenterology, Kagawa University Graduate School of Medicine, Kagawa, Japan |
| authorships[16].institutions[0].id | https://openalex.org/I201933988 |
| authorships[16].institutions[0].ror | https://ror.org/04j7mzp05 |
| authorships[16].institutions[0].type | education |
| authorships[16].institutions[0].lineage | https://openalex.org/I201933988 |
| authorships[16].institutions[0].country_code | JP |
| authorships[16].institutions[0].display_name | Kagawa University |
| authorships[16].author_position | middle |
| authorships[16].raw_author_name | Asahiro Morishita |
| authorships[16].is_corresponding | False |
| authorships[16].raw_affiliation_strings | Department of Gastroenterology, Kagawa University Graduate School of Medicine, Kagawa, Japan |
| authorships[17].author.id | https://openalex.org/A5068214058 |
| authorships[17].author.orcid | https://orcid.org/0000-0002-0976-6761 |
| authorships[17].author.display_name | Toshifumi Tada |
| authorships[17].countries | JP |
| authorships[17].affiliations[0].institution_ids | https://openalex.org/I4210133817 |
| authorships[17].affiliations[0].raw_affiliation_string | Department of Internal Medicine, Japanese Red Cross Himeji Hospital, Hyogo, Japan |
| authorships[17].institutions[0].id | https://openalex.org/I4210133817 |
| authorships[17].institutions[0].ror | https://ror.org/047sehh14 |
| authorships[17].institutions[0].type | healthcare |
| authorships[17].institutions[0].lineage | https://openalex.org/I4210133817 |
| authorships[17].institutions[0].country_code | JP |
| authorships[17].institutions[0].display_name | Himeji Red Cross Hospital |
| authorships[17].author_position | middle |
| authorships[17].raw_author_name | Toshifumi Tada |
| authorships[17].is_corresponding | False |
| authorships[17].raw_affiliation_strings | Department of Internal Medicine, Japanese Red Cross Himeji Hospital, Hyogo, Japan |
| authorships[18].author.id | https://openalex.org/A5017304406 |
| authorships[18].author.orcid | |
| authorships[18].author.display_name | Toru Asano |
| authorships[18].countries | JP |
| authorships[18].affiliations[0].institution_ids | https://openalex.org/I4210103327 |
| authorships[18].affiliations[0].raw_affiliation_string | Department of Internal Medicine, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan |
| authorships[18].institutions[0].id | https://openalex.org/I4210103327 |
| authorships[18].institutions[0].ror | https://ror.org/01dk3f134 |
| authorships[18].institutions[0].type | healthcare |
| authorships[18].institutions[0].lineage | https://openalex.org/I4210103327 |
| authorships[18].institutions[0].country_code | JP |
| authorships[18].institutions[0].display_name | Tokyo Metropolitan Bokutoh Hospital |
| authorships[18].author_position | middle |
| authorships[18].raw_author_name | Toru Asano |
| authorships[18].is_corresponding | False |
| authorships[18].raw_affiliation_strings | Department of Internal Medicine, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan |
| authorships[19].author.id | https://openalex.org/A5033725679 |
| authorships[19].author.orcid | |
| authorships[19].author.display_name | Tomonori Senoh |
| authorships[19].countries | JP |
| authorships[19].affiliations[0].institution_ids | https://openalex.org/I4210153576 |
| authorships[19].affiliations[0].raw_affiliation_string | Department of Hepatology, Kagawa Prefectural Central Hospital, Takamatsu, Japan |
| authorships[19].institutions[0].id | https://openalex.org/I4210153576 |
| authorships[19].institutions[0].ror | https://ror.org/05m8dye22 |
| authorships[19].institutions[0].type | healthcare |
| authorships[19].institutions[0].lineage | https://openalex.org/I4210153576 |
| authorships[19].institutions[0].country_code | JP |
| authorships[19].institutions[0].display_name | Kagawa Prefectural Central Hospital |
| authorships[19].author_position | middle |
| authorships[19].raw_author_name | Tomonori Senoh |
| authorships[19].is_corresponding | False |
| authorships[19].raw_affiliation_strings | Department of Hepatology, Kagawa Prefectural Central Hospital, Takamatsu, Japan |
| authorships[20].author.id | https://openalex.org/A5037009685 |
| authorships[20].author.orcid | https://orcid.org/0000-0003-1365-5391 |
| authorships[20].author.display_name | Tsunekazu Oikawa |
| authorships[20].countries | JP |
| authorships[20].affiliations[0].institution_ids | https://openalex.org/I115498069 |
| authorships[20].affiliations[0].raw_affiliation_string | Department of Gastroenterology and Hepatology, The Jikei University School of Medicine, Tokyo, Japan |
| authorships[20].institutions[0].id | https://openalex.org/I115498069 |
| authorships[20].institutions[0].ror | https://ror.org/039ygjf22 |
| authorships[20].institutions[0].type | education |
| authorships[20].institutions[0].lineage | https://openalex.org/I115498069 |
| authorships[20].institutions[0].country_code | JP |
| authorships[20].institutions[0].display_name | Jikei University School of Medicine |
| authorships[20].author_position | middle |
| authorships[20].raw_author_name | Tsunekazu Oikawa |
| authorships[20].is_corresponding | False |
| authorships[20].raw_affiliation_strings | Department of Gastroenterology and Hepatology, The Jikei University School of Medicine, Tokyo, Japan |
| authorships[21].author.id | https://openalex.org/A5049568375 |
| authorships[21].author.orcid | https://orcid.org/0000-0003-1244-4736 |
| authorships[21].author.display_name | Tomomi Okubo |
| authorships[21].countries | JP |
| authorships[21].affiliations[0].institution_ids | https://openalex.org/I4210162733 |
| authorships[21].affiliations[0].raw_affiliation_string | Department of Internal Medicine, Division of Gastroenterology, Nippon Medical School Chiba Hokusoh Hospital, Inzai, Chiba, Japan |
| authorships[21].institutions[0].id | https://openalex.org/I4210162733 |
| authorships[21].institutions[0].ror | https://ror.org/050adm910 |
| authorships[21].institutions[0].type | healthcare |
| authorships[21].institutions[0].lineage | https://openalex.org/I4210162733 |
| authorships[21].institutions[0].country_code | JP |
| authorships[21].institutions[0].display_name | Chiba Hokusou Hospital |
| authorships[21].author_position | middle |
| authorships[21].raw_author_name | Tomomi Okubo |
| authorships[21].is_corresponding | False |
| authorships[21].raw_affiliation_strings | Department of Internal Medicine, Division of Gastroenterology, Nippon Medical School Chiba Hokusoh Hospital, Inzai, Chiba, Japan |
| authorships[22].author.id | https://openalex.org/A5043762552 |
| authorships[22].author.orcid | https://orcid.org/0000-0003-2211-495X |
| authorships[22].author.display_name | Takashi Kumada |
| authorships[22].countries | JP |
| authorships[22].affiliations[0].institution_ids | https://openalex.org/I53527052 |
| authorships[22].affiliations[0].raw_affiliation_string | Department of Nursing, Gifu Kyoritsu University, Ogaki, Japan |
| authorships[22].institutions[0].id | https://openalex.org/I53527052 |
| authorships[22].institutions[0].ror | https://ror.org/005vfwz38 |
| authorships[22].institutions[0].type | education |
| authorships[22].institutions[0].lineage | https://openalex.org/I53527052 |
| authorships[22].institutions[0].country_code | JP |
| authorships[22].institutions[0].display_name | Gifu Kyoritsu University |
| authorships[22].author_position | middle |
| authorships[22].raw_author_name | Takashi Kumada |
| authorships[22].is_corresponding | False |
| authorships[22].raw_affiliation_strings | Department of Nursing, Gifu Kyoritsu University, Ogaki, Japan |
| authorships[23].author.id | https://openalex.org/A5058841198 |
| authorships[23].author.orcid | https://orcid.org/0000-0002-5558-6104 |
| authorships[23].author.display_name | Katsuhiko Iwakiri |
| authorships[23].countries | JP |
| authorships[23].affiliations[0].institution_ids | https://openalex.org/I80188885 |
| authorships[23].affiliations[0].raw_affiliation_string | Department of Internal Medicine, Division of Gastroenterology and Hepatology, Nippon Medical School, Tokyo, Japan |
| authorships[23].institutions[0].id | https://openalex.org/I80188885 |
| authorships[23].institutions[0].ror | https://ror.org/00krab219 |
| authorships[23].institutions[0].type | education |
| authorships[23].institutions[0].lineage | https://openalex.org/I80188885 |
| authorships[23].institutions[0].country_code | JP |
| authorships[23].institutions[0].display_name | Nippon Medical School |
| authorships[23].author_position | last |
| authorships[23].raw_author_name | Katsuhiko Iwakiri |
| authorships[23].is_corresponding | False |
| authorships[23].raw_affiliation_strings | Department of Internal Medicine, Division of Gastroenterology and Hepatology, Nippon Medical School, Tokyo, Japan |
| has_content.pdf | True |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/hepr.14052 |
| open_access.oa_status | hybrid |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Kinetics of the hepatitis B core‐related antigen and treatment responses in chronic hepatitis B patients treated with tenofovir alafenamide |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10340 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 1.0 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2713 |
| primary_topic.subfield.display_name | Epidemiology |
| primary_topic.display_name | Hepatitis B Virus Studies |
| related_works | https://openalex.org/W2748952813, https://openalex.org/W3031052312, https://openalex.org/W4389568370, https://openalex.org/W3032375762, https://openalex.org/W1995515455, https://openalex.org/W2080531066, https://openalex.org/W3108674512, https://openalex.org/W1506200166, https://openalex.org/W1489783725, https://openalex.org/W2148612803 |
| cited_by_count | 0 |
| locations_count | 2 |
| best_oa_location.id | doi:10.1111/hepr.14052 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S110399111 |
| best_oa_location.source.issn | 1386-6346, 1872-034X |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | 1386-6346 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Hepatology Research |
| best_oa_location.source.host_organization | https://openalex.org/P4310320595 |
| best_oa_location.source.host_organization_name | Wiley |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320595 |
| best_oa_location.source.host_organization_lineage_names | Wiley |
| best_oa_location.license | cc-by-nc |
| best_oa_location.pdf_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/hepr.14052 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by-nc |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Hepatology Research |
| best_oa_location.landing_page_url | https://doi.org/10.1111/hepr.14052 |
| primary_location.id | doi:10.1111/hepr.14052 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S110399111 |
| primary_location.source.issn | 1386-6346, 1872-034X |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 1386-6346 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Hepatology Research |
| primary_location.source.host_organization | https://openalex.org/P4310320595 |
| primary_location.source.host_organization_name | Wiley |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320595 |
| primary_location.source.host_organization_lineage_names | Wiley |
| primary_location.license | cc-by-nc |
| primary_location.pdf_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/hepr.14052 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by-nc |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Hepatology Research |
| primary_location.landing_page_url | https://doi.org/10.1111/hepr.14052 |
| publication_date | 2024-04-29 |
| publication_year | 2024 |
| referenced_works | https://openalex.org/W6922222858, https://openalex.org/W3149450293, https://openalex.org/W1994195219, https://openalex.org/W2104389844, https://openalex.org/W2739683242, https://openalex.org/W2604211538, https://openalex.org/W2070237659, https://openalex.org/W3035343564, https://openalex.org/W1524685096, https://openalex.org/W2054783695, https://openalex.org/W1533250690, https://openalex.org/W2318766603, https://openalex.org/W2913132640, https://openalex.org/W2008311601, https://openalex.org/W2037153397, https://openalex.org/W2147133758, https://openalex.org/W2734881742, https://openalex.org/W3010910207, https://openalex.org/W4212817980, https://openalex.org/W2007235791, https://openalex.org/W2586433173, https://openalex.org/W3082020504, https://openalex.org/W2126640376, https://openalex.org/W2032812836, https://openalex.org/W3200728861, https://openalex.org/W2521726183, https://openalex.org/W1912024884, https://openalex.org/W4239743462, https://openalex.org/W2161348039, https://openalex.org/W1979350526, https://openalex.org/W3129953464, https://openalex.org/W1802919929, https://openalex.org/W2888202394, https://openalex.org/W3137804151, https://openalex.org/W2056215929, https://openalex.org/W2154472829, https://openalex.org/W2544680672 |
| referenced_works_count | 37 |
| abstract_inverted_index.( | 173 |
| abstract_inverted_index.= | 175 |
| abstract_inverted_index.B | 6, 190, 238, 251 |
| abstract_inverted_index.a | 93 |
| abstract_inverted_index.p | 174 |
| abstract_inverted_index.). | 180 |
| abstract_inverted_index.10 | 178 |
| abstract_inverted_index.96 | 75, 138, 147, 169 |
| abstract_inverted_index.An | 2 |
| abstract_inverted_index.As | 228 |
| abstract_inverted_index.B, | 59, 209 |
| abstract_inverted_index.In | 38, 201 |
| abstract_inverted_index.No | 181 |
| abstract_inverted_index.an | 160, 221 |
| abstract_inverted_index.as | 92, 159 |
| abstract_inverted_index.at | 137, 146, 168 |
| abstract_inverted_index.be | 257 |
| abstract_inverted_index.in | 53, 64, 95, 129, 194, 242, 247 |
| abstract_inverted_index.is | 220 |
| abstract_inverted_index.no | 229 |
| abstract_inverted_index.of | 51, 80, 97, 113, 171 |
| abstract_inverted_index.on | 61 |
| abstract_inverted_index.to | 45, 249, 256 |
| abstract_inverted_index.we | 43 |
| abstract_inverted_index.× | 177 |
| abstract_inverted_index.241 | 110 |
| abstract_inverted_index.4.7 | 123 |
| abstract_inverted_index.Aim | 1 |
| abstract_inverted_index.TAF | 52, 72, 198, 202, 260 |
| abstract_inverted_index.The | 106, 117, 126, 142 |
| abstract_inverted_index.and | 11, 25, 49, 77, 84, 188, 215, 235 |
| abstract_inverted_index.for | 74, 204 |
| abstract_inverted_index.has | 19 |
| abstract_inverted_index.log | 99, 124, 135 |
| abstract_inverted_index.may | 254 |
| abstract_inverted_index.the | 47, 62, 78, 85, 186 |
| abstract_inverted_index.was | 122, 133, 149, 183, 231 |
| abstract_inverted_index.(NA) | 17 |
| abstract_inverted_index.4.53 | 176 |
| abstract_inverted_index.been | 21 |
| abstract_inverted_index.from | 101, 131 |
| abstract_inverted_index.high | 155 |
| abstract_inverted_index.need | 255 |
| abstract_inverted_index.rate | 145 |
| abstract_inverted_index.this | 39, 243 |
| abstract_inverted_index.were | 69, 103, 115, 212 |
| abstract_inverted_index.whom | 114 |
| abstract_inverted_index.with | 28, 56, 71, 88, 165, 197, 206, 225 |
| abstract_inverted_index.−1 | 98 |
| abstract_inverted_index.−6 | 179 |
| abstract_inverted_index.(TAF) | 34 |
| abstract_inverted_index.(t)id | 15 |
| abstract_inverted_index.36.9% | 112 |
| abstract_inverted_index.56.6% | 150 |
| abstract_inverted_index.IU/mL | 100, 136 |
| abstract_inverted_index.after | 140 |
| abstract_inverted_index.aimed | 44 |
| abstract_inverted_index.found | 184, 232 |
| abstract_inverted_index.level | 121, 158, 219 |
| abstract_inverted_index.study | 107 |
| abstract_inverted_index.weeks | 139, 148, 170 |
| abstract_inverted_index.HBcrAg | 23, 29, 65, 81, 89, 96, 120, 130, 143, 166, 187, 210, 226, 234, 245 |
| abstract_inverted_index.IU/mL. | 125 |
| abstract_inverted_index.analog | 16 |
| abstract_inverted_index.change | 94, 128 |
| abstract_inverted_index.during | 13, 31, 82, 259 |
| abstract_inverted_index.factor | 163, 223 |
| abstract_inverted_index.levels | 211, 241 |
| abstract_inverted_index.median | 118, 127 |
| abstract_inverted_index.remain | 36 |
| abstract_inverted_index.safety | 50 |
| abstract_inverted_index.study, | 42, 244 |
| abstract_inverted_index.weeks, | 76 |
| abstract_inverted_index.−1.1 | 134 |
| abstract_inverted_index.Methods | 67 |
| abstract_inverted_index.Results | 105 |
| abstract_inverted_index.alanine | 156, 217 |
| abstract_inverted_index.antigen | 8, 192, 240, 253 |
| abstract_inverted_index.between | 4, 185, 233 |
| abstract_inverted_index.chronic | 57, 207 |
| abstract_inverted_index.clarify | 46 |
| abstract_inverted_index.factors | 26, 86 |
| abstract_inverted_index.levels. | 66 |
| abstract_inverted_index.reduced | 236 |
| abstract_inverted_index.surface | 191, 239, 252 |
| abstract_inverted_index.treated | 70, 196 |
| abstract_inverted_index.(43/76). | 151 |
| abstract_inverted_index.(HBcrAg) | 9 |
| abstract_inverted_index.(defined | 91 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.Patients | 68 |
| abstract_inverted_index.addition | 248 |
| abstract_inverted_index.analysis | 153 |
| abstract_inverted_index.baseline | 119, 132, 162, 216 |
| abstract_inverted_index.efficacy | 48 |
| abstract_inverted_index.focusing | 60 |
| abstract_inverted_index.kinetics | 10, 24, 79, 193, 246 |
| abstract_inverted_index.patients | 55, 195, 205 |
| abstract_inverted_index.recently | 20 |
| abstract_inverted_index.response | 30, 90, 144, 167 |
| abstract_inverted_index.revealed | 154 |
| abstract_inverted_index.unclear. | 37 |
| abstract_inverted_index.baseline) | 102 |
| abstract_inverted_index.comprised | 109 |
| abstract_inverted_index.decreased | 214 |
| abstract_inverted_index.hepatitis | 5, 58, 189, 208, 237, 250 |
| abstract_inverted_index.important | 222 |
| abstract_inverted_index.monitored | 258 |
| abstract_inverted_index.patients, | 111 |
| abstract_inverted_index.reduction | 63 |
| abstract_inverted_index.reported. | 22 |
| abstract_inverted_index.tenofovir | 32 |
| abstract_inverted_index.treatment | 18, 83, 172 |
| abstract_inverted_index.associated | 27, 87, 164, 224 |
| abstract_inverted_index.evaluated. | 104 |
| abstract_inverted_index.nucleoside | 14 |
| abstract_inverted_index.population | 108 |
| abstract_inverted_index.reduction. | 227 |
| abstract_inverted_index.treatment. | 141, 261 |
| abstract_inverted_index.Conclusions | 200 |
| abstract_inverted_index.alafenamide | 33 |
| abstract_inverted_index.association | 3 |
| abstract_inverted_index.correlation | 182, 230 |
| abstract_inverted_index.independent | 161 |
| abstract_inverted_index.monotherapy | 73, 203 |
| abstract_inverted_index.multicenter | 40 |
| abstract_inverted_index.Multivariate | 152 |
| abstract_inverted_index.monotherapy. | 199 |
| abstract_inverted_index.transaminase | 157, 218 |
| abstract_inverted_index.retrospective | 41 |
| abstract_inverted_index.significantly | 213 |
| abstract_inverted_index.administration | 35 |
| abstract_inverted_index.core‐related | 7 |
| abstract_inverted_index.HBeAg‐positive. | 116 |
| abstract_inverted_index.treatment‐naïve | 54 |
| abstract_inverted_index.hepatocarcinogenesis | 12 |
| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5080709934 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 24 |
| corresponding_institution_ids | https://openalex.org/I80188885 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8500000238418579 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.10139125 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |