KIR3DL1 and Tox identify clonally expanded encephalitogenic neuron-specific CD8+ T cells in autoimmune encephalitis Article Swipe
Sylvain Perriot
,
Samuel Jones
,
Raphaël Genolet
,
Amandine Mathias
,
Helen Lindsay
,
Sara Bobisse
,
Giovanni Di Liberto
,
Mathieu Canales
,
Lise Queiroz
,
Christophe Sauvage
,
Ingrid Wagner
,
Larise Oberholster
,
Marie Gimenez
,
Diane Bégarie
,
Marie Théaudin
,
Caroline Pot
,
Doron Merkler
,
Raphaël Gottardo
,
Alexandre Harari
,
Renaud Du Pasquier
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1101/2024.03.25.586688
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1101/2024.03.25.586688
Autoreactive CD8+ T cells are the principal suspects in autoimmune encephalitis (AIE) with antibodies targeting intracellular neuronal antigens So far, the search for neuron-autoreactive CD8+ T cells has been focused on a few autoantigens and did not yield convincing results. Here, we leveraged natural antigen presentation by hiPSC-derived neurons to look at the global autoreactive CD8+ T cell response, independently of pre-conceived hypothesis of the autoantigens involved in the disease. This unbiased approach allowed for the identification of rare polyclonal neuron-reactive CD8+ T cells in healthy donors, and contrastingly, expanded clonotypes in two patients with anti-Ri AIE. Detailed ex vivo phenotypic characterization of these clonotypes revealed a specific transcriptional program suggestive of a pathogenic potential. In particular, this subset can be identified by the expression of KIR3DL1 and TOX. Strikingly, we could also demonstrate that CD8+ T cells found in the brain of an anti-Ri AIE patient display a similar phenotype associated with cytotoxicity and encephalitogenic features.
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- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2024.03.25.586688
- https://www.biorxiv.org/content/biorxiv/early/2024/03/29/2024.03.25.586688.full.pdf
- OA Status
- green
- Cited By
- 1
- References
- 49
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4393305263
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4393305263Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2024.03.25.586688Digital Object Identifier
- Title
-
KIR3DL1 and Tox identify clonally expanded encephalitogenic neuron-specific CD8+ T cells in autoimmune encephalitisWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-03-29Full publication date if available
- Authors
-
Sylvain Perriot, Samuel Jones, Raphaël Genolet, Amandine Mathias, Helen Lindsay, Sara Bobisse, Giovanni Di Liberto, Mathieu Canales, Lise Queiroz, Christophe Sauvage, Ingrid Wagner, Larise Oberholster, Marie Gimenez, Diane Bégarie, Marie Théaudin, Caroline Pot, Doron Merkler, Raphaël Gottardo, Alexandre Harari, Renaud Du PasquierList of authors in order
- Landing page
-
https://doi.org/10.1101/2024.03.25.586688Publisher landing page
- PDF URL
-
https://www.biorxiv.org/content/biorxiv/early/2024/03/29/2024.03.25.586688.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
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-
https://www.biorxiv.org/content/biorxiv/early/2024/03/29/2024.03.25.586688.full.pdfDirect OA link when available
- Concepts
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Immunology, Autoimmune encephalitis, CD8, Encephalitis, Biology, Virology, Medicine, Immune system, VirusTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 1Per-year citation counts (last 5 years)
- References (count)
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49Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.Here, | 41 |
| abstract_inverted_index.brain | 142 |
| abstract_inverted_index.cells | 4, 27, 84, 138 |
| abstract_inverted_index.could | 132 |
| abstract_inverted_index.found | 139 |
| abstract_inverted_index.these | 104 |
| abstract_inverted_index.yield | 38 |
| abstract_inverted_index.global | 54 |
| abstract_inverted_index.search | 22 |
| abstract_inverted_index.subset | 119 |
| abstract_inverted_index.KIR3DL1 | 127 |
| abstract_inverted_index.allowed | 74 |
| abstract_inverted_index.anti-Ri | 96, 145 |
| abstract_inverted_index.antigen | 45 |
| abstract_inverted_index.display | 148 |
| abstract_inverted_index.donors, | 87 |
| abstract_inverted_index.focused | 30 |
| abstract_inverted_index.healthy | 86 |
| abstract_inverted_index.natural | 44 |
| abstract_inverted_index.neurons | 49 |
| abstract_inverted_index.patient | 147 |
| abstract_inverted_index.program | 110 |
| abstract_inverted_index.similar | 150 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.Detailed | 98 |
| abstract_inverted_index.antigens | 18 |
| abstract_inverted_index.approach | 73 |
| abstract_inverted_index.disease. | 70 |
| abstract_inverted_index.expanded | 90 |
| abstract_inverted_index.involved | 67 |
| abstract_inverted_index.neuronal | 17 |
| abstract_inverted_index.patients | 94 |
| abstract_inverted_index.results. | 40 |
| abstract_inverted_index.revealed | 106 |
| abstract_inverted_index.specific | 108 |
| abstract_inverted_index.suspects | 8 |
| abstract_inverted_index.unbiased | 72 |
| abstract_inverted_index.features. | 157 |
| abstract_inverted_index.leveraged | 43 |
| abstract_inverted_index.phenotype | 151 |
| abstract_inverted_index.principal | 7 |
| abstract_inverted_index.response, | 59 |
| abstract_inverted_index.targeting | 15 |
| abstract_inverted_index.antibodies | 14 |
| abstract_inverted_index.associated | 152 |
| abstract_inverted_index.autoimmune | 10 |
| abstract_inverted_index.clonotypes | 91, 105 |
| abstract_inverted_index.convincing | 39 |
| abstract_inverted_index.expression | 125 |
| abstract_inverted_index.hypothesis | 63 |
| abstract_inverted_index.identified | 122 |
| abstract_inverted_index.pathogenic | 114 |
| abstract_inverted_index.phenotypic | 101 |
| abstract_inverted_index.polyclonal | 80 |
| abstract_inverted_index.potential. | 115 |
| abstract_inverted_index.suggestive | 111 |
| abstract_inverted_index.Strikingly, | 130 |
| abstract_inverted_index.demonstrate | 134 |
| abstract_inverted_index.particular, | 117 |
| abstract_inverted_index.Autoreactive | 1 |
| abstract_inverted_index.autoantigens | 34, 66 |
| abstract_inverted_index.autoreactive | 55 |
| abstract_inverted_index.cytotoxicity | 154 |
| abstract_inverted_index.encephalitis | 11 |
| abstract_inverted_index.presentation | 46 |
| abstract_inverted_index.hiPSC-derived | 48 |
| abstract_inverted_index.independently | 60 |
| abstract_inverted_index.intracellular | 16 |
| abstract_inverted_index.pre-conceived | 62 |
| abstract_inverted_index.contrastingly, | 89 |
| abstract_inverted_index.identification | 77 |
| abstract_inverted_index.neuron-reactive | 81 |
| abstract_inverted_index.transcriptional | 109 |
| abstract_inverted_index.characterization | 102 |
| abstract_inverted_index.encephalitogenic | 156 |
| abstract_inverted_index.neuron-autoreactive | 24 |
| cited_by_percentile_year.max | 94 |
| cited_by_percentile_year.min | 90 |
| corresponding_author_ids | https://openalex.org/A5075371427 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 20 |
| corresponding_institution_ids | https://openalex.org/I2802229882 |
| citation_normalized_percentile.value | 0.55463604 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |