Klebsiella pneumoniae employs a type VI secretion system to overcome microbiota-mediated colonization resistance Article Swipe
Andrew S. Bray
,
Christopher A. Broberg
,
Andrew W. Hudson
,
Wei-Sheng Wu
,
Ravinder Nagpal
,
Maidul Islam
,
Juan D. Valencia‐Bacca
,
F Shahid
,
Giovanna E. Hernandez
,
Noah A. Nutter
,
Kimberly A. Walker
,
Emma Bennett
,
Taylor M. Young
,
Andrew J. Barnes
,
David A. Ornelles
,
Virginia L. Miller
,
M. Ammar Zafar
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s41467-025-56309-8
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s41467-025-56309-8
Microbial species must compete for space and nutrients to persist in the gastrointestinal (GI) tract, and our understanding of the complex pathobiont-microbiota interactions is far from complete. Klebsiella pneumoniae, a problematic, often drug-resistant nosocomial pathogen, can colonize the GI tract asymptomatically, serving as an infection reservoir. To provide insight on how K. pneumoniae interacts with the resident gut microbiome, we conduct a transposon mutagenesis screen using a murine model of GI colonization with an intact microbiota. Among the genes identified were those encoding a type VI secretion system (T6SS), which mediates contact-dependent killing of gram-negative bacteria. From several approaches, we demonstrate that the T6SS is critical for K. pneumoniae gut colonization. Metagenomics and in vitro killing assays reveal that K. pneumoniae reduces Betaproteobacteria species in a T6SS-dependent manner, thus identifying specific species targeted by K. pneumoniae. We further show that T6SS gene expression is controlled by several transcriptional regulators and that expression only occurs in vitro under conditions that mimic the gut environment. By enabling K. pneumoniae to thrive in the gut, the T6SS indirectly contributes to the pathogenic potential of this organism. These observations advance our molecular understanding of how K. pneumoniae successfully colonizes the GI tract.
Related Topics
Concepts
Klebsiella pneumoniae
Microbiology
Colonization
Secretion
Colonisation resistance
Bacterial protein
Klebsiella
Antibiotic resistance
Biology
Type three secretion system
Bacteria
Escherichia coli
Antibiotics
Virulence
Genetics
Gene
Biochemistry
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41467-025-56309-8
- https://www.nature.com/articles/s41467-025-56309-8.pdf
- OA Status
- gold
- Cited By
- 11
- References
- 146
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4406696741
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4406696741Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1038/s41467-025-56309-8Digital Object Identifier
- Title
-
Klebsiella pneumoniae employs a type VI secretion system to overcome microbiota-mediated colonization resistanceWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-01-22Full publication date if available
- Authors
-
Andrew S. Bray, Christopher A. Broberg, Andrew W. Hudson, Wei-Sheng Wu, Ravinder Nagpal, Maidul Islam, Juan D. Valencia‐Bacca, F Shahid, Giovanna E. Hernandez, Noah A. Nutter, Kimberly A. Walker, Emma Bennett, Taylor M. Young, Andrew J. Barnes, David A. Ornelles, Virginia L. Miller, M. Ammar ZafarList of authors in order
- Landing page
-
https://doi.org/10.1038/s41467-025-56309-8Publisher landing page
- PDF URL
-
https://www.nature.com/articles/s41467-025-56309-8.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.nature.com/articles/s41467-025-56309-8.pdfDirect OA link when available
- Concepts
-
Klebsiella pneumoniae, Microbiology, Colonization, Secretion, Colonisation resistance, Bacterial protein, Klebsiella, Antibiotic resistance, Biology, Type three secretion system, Bacteria, Escherichia coli, Antibiotics, Virulence, Genetics, Gene, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
11Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 11Per-year citation counts (last 5 years)
- References (count)
-
146Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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