Knockout of Dectin-1 does not modify disease onset or progression in a MATR3 S85C knock-in mouse model of ALS Article Swipe
Justin You
,
Katarina Maksimovic
,
Karin Chen
,
Jooyun Lee
,
Anneka Schoeppe
,
Jhune Rizsan Santos
,
Mohieldin Youssef
,
Michael W. Salter
,
Jeehye Park
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1101/2024.04.18.590117
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1101/2024.04.18.590117
Microglia have been increasingly implicated in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). Dectin-1, encoded by the Clec7a gene, is highly upregulated in a specific microglial response state called disease-associated microglia (DAM) in various neurodegenerative conditions. However, the role of Dectin-1 in ALS is undetermined. Here, we show that Clec7a mRNA upregulation occurs in central nervous system (CNS) regions that exhibit neurodegeneration in a MATR3 S85C knock-in mouse model ( Matr3 S85C/S85C ) of ALS. Furthermore, a significant increase in the number of Dectin-1 + microglia coincides with the onset of motor deficits, and this number increases with disease severity. We demonstrate that the knockout of Dectin-1 does not affect survival, motor function, neurodegeneration, or microglial responses in Matr3 S85C/S85C mice. These findings suggest that Dectin-1 does not play a role in modifying ALS onset or progression but could potentially serve as a valuable biomarker for ALS severity. Subject areas Physiology; Molecular biology; Neuroscience; Immunology Highlights Clec7a upregulation is confined to central nervous system regions that exhibit overt neurodegeneration in a MATR3 S85C knock-in mouse model of ALS The appearance of Dectin-1 + microglia coincides with the onset of motor deficits, and its number increases with disease progression Knockout of Dectin-1 does not modify survival, motor deficits, neurodegeneration, or microglial responses in MATR3 S85C knock-in mice
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2024.04.18.590117
- https://www.biorxiv.org/content/biorxiv/early/2024/04/22/2024.04.18.590117.full.pdf
- OA Status
- green
- References
- 41
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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- DOI
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https://doi.org/10.1101/2024.04.18.590117Digital Object Identifier
- Title
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Knockout of Dectin-1 does not modify disease onset or progression in a MATR3 S85C knock-in mouse model of ALSWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-04-22Full publication date if available
- Authors
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Justin You, Katarina Maksimovic, Karin Chen, Jooyun Lee, Anneka Schoeppe, Jhune Rizsan Santos, Mohieldin Youssef, Michael W. Salter, Jeehye ParkList of authors in order
- Landing page
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https://doi.org/10.1101/2024.04.18.590117Publisher landing page
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https://www.biorxiv.org/content/biorxiv/early/2024/04/22/2024.04.18.590117.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
- OA URL
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https://www.biorxiv.org/content/biorxiv/early/2024/04/22/2024.04.18.590117.full.pdfDirect OA link when available
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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