KRIT1 heterozygous mutations are sufficient to induce a pathological phenotype in patient-derived iPSC models of cerebral cavernous malformation Article Swipe
Maximiliano Arce
,
Iza Erzar
,
Fan Yang
,
N. Senthilkumar
,
Favour Chinyere Onyeogaziri
,
Dario Ronchi
,
Frida C Ahlstrand
,
Nora Noll
,
Roberta Lugano
,
Mark Richards
,
Elisa Scola
,
Monica Corada
,
Francesca Lazzaroni
,
Linda Meggiolaro
,
Jens Schuster
,
Niklas Dahl
,
Mika Niemelä
,
Behnam Rezai Jahromi
,
Anna Dimberg
,
Silvia Lanfraconi
,
Roberto Latini
,
Peetra U. Magnusson
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.celrep.2025.115576
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.celrep.2025.115576
Cerebral cavernous malformation (CCM) is a neurovascular disease distinguished by clusters of leaky, mulberry-like blood vessels. KRIT1 bi-allelic loss-of-function mutations in endothelial cells are known to trigger brain cavernomas; however, human preclinical models are needed to unveil the importance of germline KRIT1 heterozygous mutations in CCM pathogenesis. We generated three induced pluripotent stem cells (iPSCs) from patients with CCM with hereditary KRIT1 heterozygous mutations. Patient-derived vascularized organoids exhibited intricate and abnormal vascular structures with cavernoma-like morphology, and iPSC-derived endothelial cells displayed phenotypic abnormalities at the junctional and transcriptional levels. Upon injection into brain explants, CCM endothelial cells integrated into the normal vasculature and created vascular anomalies. Lastly, transcriptional analysis showed that the endothelial progenitor marker paternally expressed gene 3 (PEG3) was highly expressed in iPSC-derived CCM endothelial cells, and this was further confirmed in familial and sporadic cavernoma biopsies. Overall, our study sheds light on the molecular consequence of KRIT1 heterozygous mutations in endothelial cells and the potential implications in cavernoma pathogenesis.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.celrep.2025.115576
- OA Status
- gold
- References
- 60
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4409415998
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4409415998Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1016/j.celrep.2025.115576Digital Object Identifier
- Title
-
KRIT1 heterozygous mutations are sufficient to induce a pathological phenotype in patient-derived iPSC models of cerebral cavernous malformationWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-04-14Full publication date if available
- Authors
-
Maximiliano Arce, Iza Erzar, Fan Yang, N. Senthilkumar, Favour Chinyere Onyeogaziri, Dario Ronchi, Frida C Ahlstrand, Nora Noll, Roberta Lugano, Mark Richards, Elisa Scola, Monica Corada, Francesca Lazzaroni, Linda Meggiolaro, Jens Schuster, Niklas Dahl, Mika Niemelä, Behnam Rezai Jahromi, Anna Dimberg, Silvia Lanfraconi, Roberto Latini, Peetra U. MagnussonList of authors in order
- Landing page
-
https://doi.org/10.1016/j.celrep.2025.115576Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1016/j.celrep.2025.115576Direct OA link when available
- Concepts
-
Phenotype, Pathological, Mutation, Genetics, Heterozygote advantage, Biology, Medicine, Compound heterozygosity, Allele, Pathology, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
60Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4409415998 |
|---|---|
| doi | https://doi.org/10.1016/j.celrep.2025.115576 |
| ids.doi | https://doi.org/10.1016/j.celrep.2025.115576 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/40238631 |
| ids.openalex | https://openalex.org/W4409415998 |
| fwci | 0.0 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D006801 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Humans |
| mesh[1].qualifier_ui | Q000378 |
| mesh[1].descriptor_ui | D057026 |
| mesh[1].is_major_topic | True |
| mesh[1].qualifier_name | metabolism |
| mesh[1].descriptor_name | Induced Pluripotent Stem Cells |
| mesh[2].qualifier_ui | Q000473 |
| mesh[2].descriptor_ui | D057026 |
| mesh[2].is_major_topic | True |
| mesh[2].qualifier_name | pathology |
| mesh[2].descriptor_name | Induced Pluripotent Stem Cells |
| mesh[3].qualifier_ui | Q000235 |
| mesh[3].descriptor_ui | D020786 |
| mesh[3].is_major_topic | True |
| mesh[3].qualifier_name | genetics |
| mesh[3].descriptor_name | Hemangioma, Cavernous, Central Nervous System |
| mesh[4].qualifier_ui | Q000473 |
| mesh[4].descriptor_ui | D020786 |
| mesh[4].is_major_topic | True |
| mesh[4].qualifier_name | pathology |
| mesh[4].descriptor_name | Hemangioma, Cavernous, Central Nervous System |
| mesh[5].qualifier_ui | Q000235 |
| mesh[5].descriptor_ui | D000075927 |
| mesh[5].is_major_topic | True |
| mesh[5].qualifier_name | genetics |
| mesh[5].descriptor_name | KRIT1 Protein |
| mesh[6].qualifier_ui | Q000378 |
| mesh[6].descriptor_ui | D000075927 |
| mesh[6].is_major_topic | True |
| mesh[6].qualifier_name | metabolism |
| mesh[6].descriptor_name | KRIT1 Protein |
| mesh[7].qualifier_ui | |
| mesh[7].descriptor_ui | D010641 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | |
| mesh[7].descriptor_name | Phenotype |
| mesh[8].qualifier_ui | Q000235 |
| mesh[8].descriptor_ui | D009154 |
| mesh[8].is_major_topic | True |
| mesh[8].qualifier_name | genetics |
| mesh[8].descriptor_name | Mutation |
| mesh[9].qualifier_ui | |
| mesh[9].descriptor_ui | D006579 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | |
| mesh[9].descriptor_name | Heterozygote |
| mesh[10].qualifier_ui | Q000378 |
| mesh[10].descriptor_ui | D042783 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | metabolism |
| mesh[10].descriptor_name | Endothelial Cells |
| mesh[11].qualifier_ui | Q000473 |
| mesh[11].descriptor_ui | D042783 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | pathology |
| mesh[11].descriptor_name | Endothelial Cells |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D008297 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | Male |
| mesh[13].qualifier_ui | Q000473 |
| mesh[13].descriptor_ui | D009940 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | pathology |
| mesh[13].descriptor_name | Organoids |
| mesh[14].qualifier_ui | Q000378 |
| mesh[14].descriptor_ui | D009940 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | metabolism |
| mesh[14].descriptor_name | Organoids |
| mesh[15].qualifier_ui | |
| mesh[15].descriptor_ui | D005260 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | |
| mesh[15].descriptor_name | Female |
| type | article |
| title | KRIT1 heterozygous mutations are sufficient to induce a pathological phenotype in patient-derived iPSC models of cerebral cavernous malformation |
| biblio.issue | 5 |
| biblio.volume | 44 |
| biblio.last_page | 115576 |
| biblio.first_page | 115576 |
| topics[0].id | https://openalex.org/T11402 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9998999834060669 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2728 |
| topics[0].subfield.display_name | Neurology |
| topics[0].display_name | Vascular Malformations Diagnosis and Treatment |
| topics[1].id | https://openalex.org/T11763 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9768000245094299 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2728 |
| topics[1].subfield.display_name | Neurology |
| topics[1].display_name | Intracerebral and Subarachnoid Hemorrhage Research |
| topics[2].id | https://openalex.org/T11406 |
| topics[2].field.id | https://openalex.org/fields/28 |
| topics[2].field.display_name | Neuroscience |
| topics[2].score | 0.953499972820282 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2804 |
| topics[2].subfield.display_name | Cellular and Molecular Neuroscience |
| topics[2].display_name | Cerebrospinal fluid and hydrocephalus |
| is_xpac | False |
| apc_list.value | 5200 |
| apc_list.currency | USD |
| apc_list.value_usd | 5200 |
| apc_paid.value | 5200 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 5200 |
| concepts[0].id | https://openalex.org/C127716648 |
| concepts[0].level | 3 |
| concepts[0].score | 0.7845341563224792 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q104053 |
| concepts[0].display_name | Phenotype |
| concepts[1].id | https://openalex.org/C207886595 |
| concepts[1].level | 2 |
| concepts[1].score | 0.7072274088859558 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q1456138 |
| concepts[1].display_name | Pathological |
| concepts[2].id | https://openalex.org/C501734568 |
| concepts[2].level | 3 |
| concepts[2].score | 0.5784491300582886 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q42918 |
| concepts[2].display_name | Mutation |
| concepts[3].id | https://openalex.org/C54355233 |
| concepts[3].level | 1 |
| concepts[3].score | 0.5649588704109192 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[3].display_name | Genetics |
| concepts[4].id | https://openalex.org/C153471976 |
| concepts[4].level | 4 |
| concepts[4].score | 0.4962652325630188 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q2873354 |
| concepts[4].display_name | Heterozygote advantage |
| concepts[5].id | https://openalex.org/C86803240 |
| concepts[5].level | 0 |
| concepts[5].score | 0.4462668299674988 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[5].display_name | Biology |
| concepts[6].id | https://openalex.org/C71924100 |
| concepts[6].level | 0 |
| concepts[6].score | 0.44326385855674744 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[6].display_name | Medicine |
| concepts[7].id | https://openalex.org/C12125453 |
| concepts[7].level | 4 |
| concepts[7].score | 0.4151211380958557 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q5156837 |
| concepts[7].display_name | Compound heterozygosity |
| concepts[8].id | https://openalex.org/C180754005 |
| concepts[8].level | 3 |
| concepts[8].score | 0.3662649393081665 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q80726 |
| concepts[8].display_name | Allele |
| concepts[9].id | https://openalex.org/C142724271 |
| concepts[9].level | 1 |
| concepts[9].score | 0.3201430141925812 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q7208 |
| concepts[9].display_name | Pathology |
| concepts[10].id | https://openalex.org/C104317684 |
| concepts[10].level | 2 |
| concepts[10].score | 0.23825445771217346 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[10].display_name | Gene |
| keywords[0].id | https://openalex.org/keywords/phenotype |
| keywords[0].score | 0.7845341563224792 |
| keywords[0].display_name | Phenotype |
| keywords[1].id | https://openalex.org/keywords/pathological |
| keywords[1].score | 0.7072274088859558 |
| keywords[1].display_name | Pathological |
| keywords[2].id | https://openalex.org/keywords/mutation |
| keywords[2].score | 0.5784491300582886 |
| keywords[2].display_name | Mutation |
| keywords[3].id | https://openalex.org/keywords/genetics |
| keywords[3].score | 0.5649588704109192 |
| keywords[3].display_name | Genetics |
| keywords[4].id | https://openalex.org/keywords/heterozygote-advantage |
| keywords[4].score | 0.4962652325630188 |
| keywords[4].display_name | Heterozygote advantage |
| keywords[5].id | https://openalex.org/keywords/biology |
| keywords[5].score | 0.4462668299674988 |
| keywords[5].display_name | Biology |
| keywords[6].id | https://openalex.org/keywords/medicine |
| keywords[6].score | 0.44326385855674744 |
| keywords[6].display_name | Medicine |
| keywords[7].id | https://openalex.org/keywords/compound-heterozygosity |
| keywords[7].score | 0.4151211380958557 |
| keywords[7].display_name | Compound heterozygosity |
| keywords[8].id | https://openalex.org/keywords/allele |
| keywords[8].score | 0.3662649393081665 |
| keywords[8].display_name | Allele |
| keywords[9].id | https://openalex.org/keywords/pathology |
| keywords[9].score | 0.3201430141925812 |
| keywords[9].display_name | Pathology |
| keywords[10].id | https://openalex.org/keywords/gene |
| keywords[10].score | 0.23825445771217346 |
| keywords[10].display_name | Gene |
| language | en |
| locations[0].id | doi:10.1016/j.celrep.2025.115576 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S169236886 |
| locations[0].source.issn | 2211-1247, 2639-1856 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2211-1247 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Cell Reports |
| locations[0].source.host_organization | https://openalex.org/P4310315673 |
| locations[0].source.host_organization_name | Cell Press |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310315673 |
| locations[0].license | cc-by |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Cell Reports |
| locations[0].landing_page_url | https://doi.org/10.1016/j.celrep.2025.115576 |
| locations[1].id | pmid:40238631 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Cell reports |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/40238631 |
| locations[2].id | pmh:oai:DiVA.org:uu-556062 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306400013 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | Publications (Konstfack University of Arts, Crafts, and Design) |
| locations[2].source.host_organization | https://openalex.org/I218177685 |
| locations[2].source.host_organization_name | University College of Arts Crafts and Design |
| locations[2].source.host_organization_lineage | https://openalex.org/I218177685 |
| locations[2].license | other-oa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | text |
| locations[2].license_id | https://openalex.org/licenses/other-oa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | |
| locations[2].landing_page_url | http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-556062 |
| locations[3].id | pmh:oai:doaj.org/article:52296c60891040d58f95242f1c2d9068 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S4306401280 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[3].source.host_organization | |
| locations[3].source.host_organization_name | |
| locations[3].source.host_organization_lineage | |
| locations[3].license | cc-by-sa |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | article |
| locations[3].license_id | https://openalex.org/licenses/cc-by-sa |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Cell Reports, Vol 44, Iss 5, Pp 115576- (2025) |
| locations[3].landing_page_url | https://doaj.org/article/52296c60891040d58f95242f1c2d9068 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5087126333 |
| authorships[0].author.orcid | https://orcid.org/0000-0001-6286-7302 |
| authorships[0].author.display_name | Maximiliano Arce |
| authorships[0].countries | SE |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I123387679, https://openalex.org/I2800139495 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden; Science for Life Laboratory, Uppsala, Sweden. Electronic address: [email protected]. |
| authorships[0].institutions[0].id | https://openalex.org/I2800139495 |
| authorships[0].institutions[0].ror | https://ror.org/04ev03g22 |
| authorships[0].institutions[0].type | facility |
| authorships[0].institutions[0].lineage | https://openalex.org/I2800139495 |
| authorships[0].institutions[0].country_code | SE |
| authorships[0].institutions[0].display_name | Science for Life Laboratory |
| authorships[0].institutions[1].id | https://openalex.org/I123387679 |
| authorships[0].institutions[1].ror | https://ror.org/048a87296 |
| authorships[0].institutions[1].type | education |
| authorships[0].institutions[1].lineage | https://openalex.org/I123387679 |
| authorships[0].institutions[1].country_code | SE |
| authorships[0].institutions[1].display_name | Uppsala University |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Maximiliano Arce |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden; Science for Life Laboratory, Uppsala, Sweden. Electronic address: [email protected]. |
| authorships[1].author.id | https://openalex.org/A5114992246 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Iza Erzar |
| authorships[1].countries | SE |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I123387679, https://openalex.org/I2800139495 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden; Science for Life Laboratory, Uppsala, Sweden. |
| authorships[1].institutions[0].id | https://openalex.org/I2800139495 |
| authorships[1].institutions[0].ror | https://ror.org/04ev03g22 |
| authorships[1].institutions[0].type | facility |
| authorships[1].institutions[0].lineage | https://openalex.org/I2800139495 |
| authorships[1].institutions[0].country_code | SE |
| authorships[1].institutions[0].display_name | Science for Life Laboratory |
| authorships[1].institutions[1].id | https://openalex.org/I123387679 |
| authorships[1].institutions[1].ror | https://ror.org/048a87296 |
| authorships[1].institutions[1].type | education |
| authorships[1].institutions[1].lineage | https://openalex.org/I123387679 |
| authorships[1].institutions[1].country_code | SE |
| authorships[1].institutions[1].display_name | Uppsala University |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Iza Erzar |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden; Science for Life Laboratory, Uppsala, Sweden. |
| authorships[2].author.id | https://openalex.org/A5079498299 |
| authorships[2].author.orcid | https://orcid.org/0009-0008-5468-4782 |
| authorships[2].author.display_name | Fan Yang |
| authorships[2].countries | SE |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I123387679, https://openalex.org/I2800139495 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden; Science for Life Laboratory, Uppsala, Sweden. |
| authorships[2].institutions[0].id | https://openalex.org/I2800139495 |
| authorships[2].institutions[0].ror | https://ror.org/04ev03g22 |
| authorships[2].institutions[0].type | facility |
| authorships[2].institutions[0].lineage | https://openalex.org/I2800139495 |
| authorships[2].institutions[0].country_code | SE |
| authorships[2].institutions[0].display_name | Science for Life Laboratory |
| authorships[2].institutions[1].id | https://openalex.org/I123387679 |
| authorships[2].institutions[1].ror | https://ror.org/048a87296 |
| authorships[2].institutions[1].type | education |
| authorships[2].institutions[1].lineage | https://openalex.org/I123387679 |
| authorships[2].institutions[1].country_code | SE |
| authorships[2].institutions[1].display_name | Uppsala University |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Fan Yang |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden; Science for Life Laboratory, Uppsala, Sweden. |
| authorships[3].author.id | https://openalex.org/A5067665485 |
| authorships[3].author.orcid | https://orcid.org/0000-0003-0694-8460 |
| authorships[3].author.display_name | N. Senthilkumar |
| authorships[3].countries | SE |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I123387679, https://openalex.org/I2800139495 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden; Science for Life Laboratory, Uppsala, Sweden. |
| authorships[3].institutions[0].id | https://openalex.org/I2800139495 |
| authorships[3].institutions[0].ror | https://ror.org/04ev03g22 |
| authorships[3].institutions[0].type | facility |
| authorships[3].institutions[0].lineage | https://openalex.org/I2800139495 |
| authorships[3].institutions[0].country_code | SE |
| authorships[3].institutions[0].display_name | Science for Life Laboratory |
| authorships[3].institutions[1].id | https://openalex.org/I123387679 |
| authorships[3].institutions[1].ror | https://ror.org/048a87296 |
| authorships[3].institutions[1].type | education |
| authorships[3].institutions[1].lineage | https://openalex.org/I123387679 |
| authorships[3].institutions[1].country_code | SE |
| authorships[3].institutions[1].display_name | Uppsala University |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Neeharika Senthilkumar |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden; Science for Life Laboratory, Uppsala, Sweden. |
| authorships[4].author.id | https://openalex.org/A5085267095 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-5742-0474 |
| authorships[4].author.display_name | Favour Chinyere Onyeogaziri |
| authorships[4].countries | SE |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I123387679, https://openalex.org/I2800139495 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden; Science for Life Laboratory, Uppsala, Sweden. |
| authorships[4].institutions[0].id | https://openalex.org/I2800139495 |
| authorships[4].institutions[0].ror | https://ror.org/04ev03g22 |
| authorships[4].institutions[0].type | facility |
| authorships[4].institutions[0].lineage | https://openalex.org/I2800139495 |
| authorships[4].institutions[0].country_code | SE |
| authorships[4].institutions[0].display_name | Science for Life Laboratory |
| authorships[4].institutions[1].id | https://openalex.org/I123387679 |
| authorships[4].institutions[1].ror | https://ror.org/048a87296 |
| authorships[4].institutions[1].type | education |
| authorships[4].institutions[1].lineage | https://openalex.org/I123387679 |
| authorships[4].institutions[1].country_code | SE |
| authorships[4].institutions[1].display_name | Uppsala University |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Favour C Onyeogaziri |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden; Science for Life Laboratory, Uppsala, Sweden. |
| authorships[5].author.id | https://openalex.org/A5025891628 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-6093-9816 |
| authorships[5].author.display_name | Dario Ronchi |
| authorships[5].countries | IT |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I189158943, https://openalex.org/I2803066834 |
| authorships[5].affiliations[0].raw_affiliation_string | Neurology Unit, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy; Dino Ferrari Center, Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy. |
| authorships[5].institutions[0].id | https://openalex.org/I2803066834 |
| authorships[5].institutions[0].ror | https://ror.org/016zn0y21 |
| authorships[5].institutions[0].type | healthcare |
| authorships[5].institutions[0].lineage | https://openalex.org/I2803066834, https://openalex.org/I4210153126 |
| authorships[5].institutions[0].country_code | IT |
| authorships[5].institutions[0].display_name | Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico |
| authorships[5].institutions[1].id | https://openalex.org/I189158943 |
| authorships[5].institutions[1].ror | https://ror.org/00wjc7c48 |
| authorships[5].institutions[1].type | education |
| authorships[5].institutions[1].lineage | https://openalex.org/I189158943 |
| authorships[5].institutions[1].country_code | IT |
| authorships[5].institutions[1].display_name | University of Milan |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Dario Ronchi |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Neurology Unit, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy; Dino Ferrari Center, Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy. |
| authorships[6].author.id | https://openalex.org/A5117136379 |
| authorships[6].author.orcid | |
| authorships[6].author.display_name | Frida C Ahlstrand |
| authorships[6].countries | SE |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I123387679, https://openalex.org/I2800139495 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden; Science for Life Laboratory, Uppsala, Sweden. |
| authorships[6].institutions[0].id | https://openalex.org/I2800139495 |
| authorships[6].institutions[0].ror | https://ror.org/04ev03g22 |
| authorships[6].institutions[0].type | facility |
| authorships[6].institutions[0].lineage | https://openalex.org/I2800139495 |
| authorships[6].institutions[0].country_code | SE |
| authorships[6].institutions[0].display_name | Science for Life Laboratory |
| authorships[6].institutions[1].id | https://openalex.org/I123387679 |
| authorships[6].institutions[1].ror | https://ror.org/048a87296 |
| authorships[6].institutions[1].type | education |
| authorships[6].institutions[1].lineage | https://openalex.org/I123387679 |
| authorships[6].institutions[1].country_code | SE |
| authorships[6].institutions[1].display_name | Uppsala University |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Frida C Ahlstrand |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden; Science for Life Laboratory, Uppsala, Sweden. |
| authorships[7].author.id | https://openalex.org/A5117136380 |
| authorships[7].author.orcid | |
| authorships[7].author.display_name | Nora Noll |
| authorships[7].countries | SE |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I123387679, https://openalex.org/I2800139495 |
| authorships[7].affiliations[0].raw_affiliation_string | Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden; Science for Life Laboratory, Uppsala, Sweden. |
| authorships[7].institutions[0].id | https://openalex.org/I2800139495 |
| authorships[7].institutions[0].ror | https://ror.org/04ev03g22 |
| authorships[7].institutions[0].type | facility |
| authorships[7].institutions[0].lineage | https://openalex.org/I2800139495 |
| authorships[7].institutions[0].country_code | SE |
| authorships[7].institutions[0].display_name | Science for Life Laboratory |
| authorships[7].institutions[1].id | https://openalex.org/I123387679 |
| authorships[7].institutions[1].ror | https://ror.org/048a87296 |
| authorships[7].institutions[1].type | education |
| authorships[7].institutions[1].lineage | https://openalex.org/I123387679 |
| authorships[7].institutions[1].country_code | SE |
| authorships[7].institutions[1].display_name | Uppsala University |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Nora Noll |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden; Science for Life Laboratory, Uppsala, Sweden. |
| authorships[8].author.id | https://openalex.org/A5074102832 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-7294-345X |
| authorships[8].author.display_name | Roberta Lugano |
| authorships[8].countries | SE |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I123387679, https://openalex.org/I2800139495 |
| authorships[8].affiliations[0].raw_affiliation_string | Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden; Science for Life Laboratory, Uppsala, Sweden. |
| authorships[8].institutions[0].id | https://openalex.org/I2800139495 |
| authorships[8].institutions[0].ror | https://ror.org/04ev03g22 |
| authorships[8].institutions[0].type | facility |
| authorships[8].institutions[0].lineage | https://openalex.org/I2800139495 |
| authorships[8].institutions[0].country_code | SE |
| authorships[8].institutions[0].display_name | Science for Life Laboratory |
| authorships[8].institutions[1].id | https://openalex.org/I123387679 |
| authorships[8].institutions[1].ror | https://ror.org/048a87296 |
| authorships[8].institutions[1].type | education |
| authorships[8].institutions[1].lineage | https://openalex.org/I123387679 |
| authorships[8].institutions[1].country_code | SE |
| authorships[8].institutions[1].display_name | Uppsala University |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Roberta Lugano |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden; Science for Life Laboratory, Uppsala, Sweden. |
| authorships[9].author.id | https://openalex.org/A5031262573 |
| authorships[9].author.orcid | https://orcid.org/0000-0002-2023-8177 |
| authorships[9].author.display_name | Mark Richards |
| authorships[9].countries | SE |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I123387679, https://openalex.org/I2800139495 |
| authorships[9].affiliations[0].raw_affiliation_string | Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden; Science for Life Laboratory, Uppsala, Sweden. |
| authorships[9].institutions[0].id | https://openalex.org/I2800139495 |
| authorships[9].institutions[0].ror | https://ror.org/04ev03g22 |
| authorships[9].institutions[0].type | facility |
| authorships[9].institutions[0].lineage | https://openalex.org/I2800139495 |
| authorships[9].institutions[0].country_code | SE |
| authorships[9].institutions[0].display_name | Science for Life Laboratory |
| authorships[9].institutions[1].id | https://openalex.org/I123387679 |
| authorships[9].institutions[1].ror | https://ror.org/048a87296 |
| authorships[9].institutions[1].type | education |
| authorships[9].institutions[1].lineage | https://openalex.org/I123387679 |
| authorships[9].institutions[1].country_code | SE |
| authorships[9].institutions[1].display_name | Uppsala University |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Mark Richards |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden; Science for Life Laboratory, Uppsala, Sweden. |
| authorships[10].author.id | https://openalex.org/A5034586936 |
| authorships[10].author.orcid | https://orcid.org/0000-0001-9056-4122 |
| authorships[10].author.display_name | Elisa Scola |
| authorships[10].countries | IT |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I2803066834 |
| authorships[10].affiliations[0].raw_affiliation_string | Neuroradiology Unit, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy. |
| authorships[10].institutions[0].id | https://openalex.org/I2803066834 |
| authorships[10].institutions[0].ror | https://ror.org/016zn0y21 |
| authorships[10].institutions[0].type | healthcare |
| authorships[10].institutions[0].lineage | https://openalex.org/I2803066834, https://openalex.org/I4210153126 |
| authorships[10].institutions[0].country_code | IT |
| authorships[10].institutions[0].display_name | Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Elisa Scola |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Neuroradiology Unit, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy. |
| authorships[11].author.id | https://openalex.org/A5063953953 |
| authorships[11].author.orcid | https://orcid.org/0000-0001-8220-0871 |
| authorships[11].author.display_name | Monica Corada |
| authorships[11].countries | IT |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I4210114103 |
| authorships[11].affiliations[0].raw_affiliation_string | IFOM-ETS, The AIRC Institute of Molecular Oncology, Milan, Italy. |
| authorships[11].institutions[0].id | https://openalex.org/I4210114103 |
| authorships[11].institutions[0].ror | https://ror.org/02hcsa680 |
| authorships[11].institutions[0].type | facility |
| authorships[11].institutions[0].lineage | https://openalex.org/I4210114103 |
| authorships[11].institutions[0].country_code | IT |
| authorships[11].institutions[0].display_name | IFOM |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Monica Corada |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | IFOM-ETS, The AIRC Institute of Molecular Oncology, Milan, Italy. |
| authorships[12].author.id | https://openalex.org/A5001594376 |
| authorships[12].author.orcid | https://orcid.org/0000-0001-5767-7846 |
| authorships[12].author.display_name | Francesca Lazzaroni |
| authorships[12].countries | IT |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I2803066834, https://openalex.org/I4210087357 |
| authorships[12].affiliations[0].raw_affiliation_string | Hematology Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. |
| authorships[12].institutions[0].id | https://openalex.org/I2803066834 |
| authorships[12].institutions[0].ror | https://ror.org/016zn0y21 |
| authorships[12].institutions[0].type | healthcare |
| authorships[12].institutions[0].lineage | https://openalex.org/I2803066834, https://openalex.org/I4210153126 |
| authorships[12].institutions[0].country_code | IT |
| authorships[12].institutions[0].display_name | Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico |
| authorships[12].institutions[1].id | https://openalex.org/I4210087357 |
| authorships[12].institutions[1].ror | https://ror.org/0053ctp29 |
| authorships[12].institutions[1].type | healthcare |
| authorships[12].institutions[1].lineage | https://openalex.org/I4210087357 |
| authorships[12].institutions[1].country_code | IT |
| authorships[12].institutions[1].display_name | Ospedale Maggiore |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Francesca Lazzaroni |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | Hematology Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. |
| authorships[13].author.id | https://openalex.org/A5117136377 |
| authorships[13].author.orcid | |
| authorships[13].author.display_name | Linda Meggiolaro |
| authorships[13].countries | GB |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I28407311, https://openalex.org/I3130352432 |
| authorships[13].affiliations[0].raw_affiliation_string | Division of Cell Matrix Biology & Regenerative Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. |
| authorships[13].institutions[0].id | https://openalex.org/I3130352432 |
| authorships[13].institutions[0].ror | https://ror.org/013a0r905 |
| authorships[13].institutions[0].type | education |
| authorships[13].institutions[0].lineage | https://openalex.org/I3130352432 |
| authorships[13].institutions[0].country_code | GB |
| authorships[13].institutions[0].display_name | Henry Royce Institute |
| authorships[13].institutions[1].id | https://openalex.org/I28407311 |
| authorships[13].institutions[1].ror | https://ror.org/027m9bs27 |
| authorships[13].institutions[1].type | education |
| authorships[13].institutions[1].lineage | https://openalex.org/I28407311 |
| authorships[13].institutions[1].country_code | GB |
| authorships[13].institutions[1].display_name | University of Manchester |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Linda Meggiolaro |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | Division of Cell Matrix Biology & Regenerative Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. |
| authorships[14].author.id | https://openalex.org/A5058502394 |
| authorships[14].author.orcid | https://orcid.org/0000-0002-4383-9880 |
| authorships[14].author.display_name | Jens Schuster |
| authorships[14].countries | SE |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I123387679, https://openalex.org/I2800139495 |
| authorships[14].affiliations[0].raw_affiliation_string | Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden; Science for Life Laboratory, Uppsala, Sweden. |
| authorships[14].institutions[0].id | https://openalex.org/I2800139495 |
| authorships[14].institutions[0].ror | https://ror.org/04ev03g22 |
| authorships[14].institutions[0].type | facility |
| authorships[14].institutions[0].lineage | https://openalex.org/I2800139495 |
| authorships[14].institutions[0].country_code | SE |
| authorships[14].institutions[0].display_name | Science for Life Laboratory |
| authorships[14].institutions[1].id | https://openalex.org/I123387679 |
| authorships[14].institutions[1].ror | https://ror.org/048a87296 |
| authorships[14].institutions[1].type | education |
| authorships[14].institutions[1].lineage | https://openalex.org/I123387679 |
| authorships[14].institutions[1].country_code | SE |
| authorships[14].institutions[1].display_name | Uppsala University |
| authorships[14].author_position | middle |
| authorships[14].raw_author_name | Jens Schuster |
| authorships[14].is_corresponding | False |
| authorships[14].raw_affiliation_strings | Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden; Science for Life Laboratory, Uppsala, Sweden. |
| authorships[15].author.id | https://openalex.org/A5080820625 |
| authorships[15].author.orcid | https://orcid.org/0000-0002-8122-0800 |
| authorships[15].author.display_name | Niklas Dahl |
| authorships[15].countries | SE |
| authorships[15].affiliations[0].institution_ids | https://openalex.org/I123387679, https://openalex.org/I2800139495 |
| authorships[15].affiliations[0].raw_affiliation_string | Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden; Science for Life Laboratory, Uppsala, Sweden. |
| authorships[15].institutions[0].id | https://openalex.org/I2800139495 |
| authorships[15].institutions[0].ror | https://ror.org/04ev03g22 |
| authorships[15].institutions[0].type | facility |
| authorships[15].institutions[0].lineage | https://openalex.org/I2800139495 |
| authorships[15].institutions[0].country_code | SE |
| authorships[15].institutions[0].display_name | Science for Life Laboratory |
| authorships[15].institutions[1].id | https://openalex.org/I123387679 |
| authorships[15].institutions[1].ror | https://ror.org/048a87296 |
| authorships[15].institutions[1].type | education |
| authorships[15].institutions[1].lineage | https://openalex.org/I123387679 |
| authorships[15].institutions[1].country_code | SE |
| authorships[15].institutions[1].display_name | Uppsala University |
| authorships[15].author_position | middle |
| authorships[15].raw_author_name | Niklas Dahl |
| authorships[15].is_corresponding | False |
| authorships[15].raw_affiliation_strings | Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden; Science for Life Laboratory, Uppsala, Sweden. |
| authorships[16].author.id | https://openalex.org/A5008804634 |
| authorships[16].author.orcid | https://orcid.org/0000-0003-1526-0684 |
| authorships[16].author.display_name | Mika Niemelä |
| authorships[16].countries | FI |
| authorships[16].affiliations[0].institution_ids | https://openalex.org/I133731052, https://openalex.org/I2800394112 |
| authorships[16].affiliations[0].raw_affiliation_string | Department of Neurosurgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. |
| authorships[16].institutions[0].id | https://openalex.org/I2800394112 |
| authorships[16].institutions[0].ror | https://ror.org/02e8hzf44 |
| authorships[16].institutions[0].type | healthcare |
| authorships[16].institutions[0].lineage | https://openalex.org/I2800394112, https://openalex.org/I4210166427 |
| authorships[16].institutions[0].country_code | FI |
| authorships[16].institutions[0].display_name | Helsinki University Hospital |
| authorships[16].institutions[1].id | https://openalex.org/I133731052 |
| authorships[16].institutions[1].ror | https://ror.org/040af2s02 |
| authorships[16].institutions[1].type | education |
| authorships[16].institutions[1].lineage | https://openalex.org/I133731052 |
| authorships[16].institutions[1].country_code | FI |
| authorships[16].institutions[1].display_name | University of Helsinki |
| authorships[16].author_position | middle |
| authorships[16].raw_author_name | Mika Niemelä |
| authorships[16].is_corresponding | False |
| authorships[16].raw_affiliation_strings | Department of Neurosurgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. |
| authorships[17].author.id | https://openalex.org/A5020685129 |
| authorships[17].author.orcid | https://orcid.org/0000-0003-3937-2816 |
| authorships[17].author.display_name | Behnam Rezai Jahromi |
| authorships[17].countries | FI |
| authorships[17].affiliations[0].institution_ids | https://openalex.org/I133731052, https://openalex.org/I2800394112 |
| authorships[17].affiliations[0].raw_affiliation_string | Department of Neurosurgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. |
| authorships[17].institutions[0].id | https://openalex.org/I2800394112 |
| authorships[17].institutions[0].ror | https://ror.org/02e8hzf44 |
| authorships[17].institutions[0].type | healthcare |
| authorships[17].institutions[0].lineage | https://openalex.org/I2800394112, https://openalex.org/I4210166427 |
| authorships[17].institutions[0].country_code | FI |
| authorships[17].institutions[0].display_name | Helsinki University Hospital |
| authorships[17].institutions[1].id | https://openalex.org/I133731052 |
| authorships[17].institutions[1].ror | https://ror.org/040af2s02 |
| authorships[17].institutions[1].type | education |
| authorships[17].institutions[1].lineage | https://openalex.org/I133731052 |
| authorships[17].institutions[1].country_code | FI |
| authorships[17].institutions[1].display_name | University of Helsinki |
| authorships[17].author_position | middle |
| authorships[17].raw_author_name | Behnam Rezai Jahromi |
| authorships[17].is_corresponding | False |
| authorships[17].raw_affiliation_strings | Department of Neurosurgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. |
| authorships[18].author.id | https://openalex.org/A5004585831 |
| authorships[18].author.orcid | https://orcid.org/0000-0003-4422-9125 |
| authorships[18].author.display_name | Anna Dimberg |
| authorships[18].countries | SE |
| authorships[18].affiliations[0].institution_ids | https://openalex.org/I123387679, https://openalex.org/I2800139495 |
| authorships[18].affiliations[0].raw_affiliation_string | Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden; Science for Life Laboratory, Uppsala, Sweden. |
| authorships[18].institutions[0].id | https://openalex.org/I2800139495 |
| authorships[18].institutions[0].ror | https://ror.org/04ev03g22 |
| authorships[18].institutions[0].type | facility |
| authorships[18].institutions[0].lineage | https://openalex.org/I2800139495 |
| authorships[18].institutions[0].country_code | SE |
| authorships[18].institutions[0].display_name | Science for Life Laboratory |
| authorships[18].institutions[1].id | https://openalex.org/I123387679 |
| authorships[18].institutions[1].ror | https://ror.org/048a87296 |
| authorships[18].institutions[1].type | education |
| authorships[18].institutions[1].lineage | https://openalex.org/I123387679 |
| authorships[18].institutions[1].country_code | SE |
| authorships[18].institutions[1].display_name | Uppsala University |
| authorships[18].author_position | middle |
| authorships[18].raw_author_name | Anna Dimberg |
| authorships[18].is_corresponding | False |
| authorships[18].raw_affiliation_strings | Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden; Science for Life Laboratory, Uppsala, Sweden. |
| authorships[19].author.id | https://openalex.org/A5117136378 |
| authorships[19].author.orcid | |
| authorships[19].author.display_name | Silvia Lanfraconi |
| authorships[19].countries | IT |
| authorships[19].affiliations[0].institution_ids | https://openalex.org/I2803066834 |
| authorships[19].affiliations[0].raw_affiliation_string | Neurology Unit, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy. |
| authorships[19].institutions[0].id | https://openalex.org/I2803066834 |
| authorships[19].institutions[0].ror | https://ror.org/016zn0y21 |
| authorships[19].institutions[0].type | healthcare |
| authorships[19].institutions[0].lineage | https://openalex.org/I2803066834, https://openalex.org/I4210153126 |
| authorships[19].institutions[0].country_code | IT |
| authorships[19].institutions[0].display_name | Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico |
| authorships[19].author_position | middle |
| authorships[19].raw_author_name | Silvia Lanfraconi |
| authorships[19].is_corresponding | False |
| authorships[19].raw_affiliation_strings | Neurology Unit, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy. |
| authorships[20].author.id | https://openalex.org/A5027518592 |
| authorships[20].author.orcid | https://orcid.org/0000-0002-3729-4650 |
| authorships[20].author.display_name | Roberto Latini |
| authorships[20].countries | IT |
| authorships[20].affiliations[0].institution_ids | https://openalex.org/I19630809 |
| authorships[20].affiliations[0].raw_affiliation_string | Department of Acute Brain and Cardiovascular Injury, Institute for Pharmacological Research Mario Negri IRCCS, Milan, Italy. |
| authorships[20].institutions[0].id | https://openalex.org/I19630809 |
| authorships[20].institutions[0].ror | https://ror.org/05aspc753 |
| authorships[20].institutions[0].type | nonprofit |
| authorships[20].institutions[0].lineage | https://openalex.org/I19630809, https://openalex.org/I4210110338, https://openalex.org/I4210153126 |
| authorships[20].institutions[0].country_code | IT |
| authorships[20].institutions[0].display_name | Mario Negri Institute for Pharmacological Research |
| authorships[20].author_position | middle |
| authorships[20].raw_author_name | Roberto Latini |
| authorships[20].is_corresponding | False |
| authorships[20].raw_affiliation_strings | Department of Acute Brain and Cardiovascular Injury, Institute for Pharmacological Research Mario Negri IRCCS, Milan, Italy. |
| authorships[21].author.id | https://openalex.org/A5009651042 |
| authorships[21].author.orcid | https://orcid.org/0000-0003-1142-854X |
| authorships[21].author.display_name | Peetra U. Magnusson |
| authorships[21].countries | SE |
| authorships[21].affiliations[0].institution_ids | https://openalex.org/I123387679, https://openalex.org/I2800139495 |
| authorships[21].affiliations[0].raw_affiliation_string | Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden; Science for Life Laboratory, Uppsala, Sweden. Electronic address: [email protected]. |
| authorships[21].institutions[0].id | https://openalex.org/I2800139495 |
| authorships[21].institutions[0].ror | https://ror.org/04ev03g22 |
| authorships[21].institutions[0].type | facility |
| authorships[21].institutions[0].lineage | https://openalex.org/I2800139495 |
| authorships[21].institutions[0].country_code | SE |
| authorships[21].institutions[0].display_name | Science for Life Laboratory |
| authorships[21].institutions[1].id | https://openalex.org/I123387679 |
| authorships[21].institutions[1].ror | https://ror.org/048a87296 |
| authorships[21].institutions[1].type | education |
| authorships[21].institutions[1].lineage | https://openalex.org/I123387679 |
| authorships[21].institutions[1].country_code | SE |
| authorships[21].institutions[1].display_name | Uppsala University |
| authorships[21].author_position | last |
| authorships[21].raw_author_name | Peetra U Magnusson |
| authorships[21].is_corresponding | False |
| authorships[21].raw_affiliation_strings | Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden; Science for Life Laboratory, Uppsala, Sweden. Electronic address: [email protected]. |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://doi.org/10.1016/j.celrep.2025.115576 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | KRIT1 heterozygous mutations are sufficient to induce a pathological phenotype in patient-derived iPSC models of cerebral cavernous malformation |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11402 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9998999834060669 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2728 |
| primary_topic.subfield.display_name | Neurology |
| primary_topic.display_name | Vascular Malformations Diagnosis and Treatment |
| related_works | https://openalex.org/W2363132949, https://openalex.org/W2027245384, https://openalex.org/W2090410200, https://openalex.org/W2029946833, https://openalex.org/W1993854347, https://openalex.org/W2359850611, https://openalex.org/W2161547424, https://openalex.org/W188750885, https://openalex.org/W2389252788, https://openalex.org/W2054509832 |
| cited_by_count | 0 |
| locations_count | 4 |
| best_oa_location.id | doi:10.1016/j.celrep.2025.115576 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S169236886 |
| best_oa_location.source.issn | 2211-1247, 2639-1856 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2211-1247 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Cell Reports |
| best_oa_location.source.host_organization | https://openalex.org/P4310315673 |
| best_oa_location.source.host_organization_name | Cell Press |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310315673 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Cell Reports |
| best_oa_location.landing_page_url | https://doi.org/10.1016/j.celrep.2025.115576 |
| primary_location.id | doi:10.1016/j.celrep.2025.115576 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S169236886 |
| primary_location.source.issn | 2211-1247, 2639-1856 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2211-1247 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Cell Reports |
| primary_location.source.host_organization | https://openalex.org/P4310315673 |
| primary_location.source.host_organization_name | Cell Press |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310315673 |
| primary_location.license | cc-by |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Cell Reports |
| primary_location.landing_page_url | https://doi.org/10.1016/j.celrep.2025.115576 |
| publication_date | 2025-04-14 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W2037931437, https://openalex.org/W3174492734, https://openalex.org/W4220786944, https://openalex.org/W4306925971, https://openalex.org/W6851866229, https://openalex.org/W3015025685, https://openalex.org/W4285005553, https://openalex.org/W2138977668, https://openalex.org/W4309236563, https://openalex.org/W2529224003, https://openalex.org/W2084201375, https://openalex.org/W2995219502, https://openalex.org/W2975652314, https://openalex.org/W3011188387, https://openalex.org/W6774017203, https://openalex.org/W3159826075, https://openalex.org/W3173691957, https://openalex.org/W4405003160, https://openalex.org/W4293067490, https://openalex.org/W2171538469, https://openalex.org/W2095035711, https://openalex.org/W2175209522, https://openalex.org/W2333129081, https://openalex.org/W2954600468, https://openalex.org/W2951067314, https://openalex.org/W2579071709, https://openalex.org/W4400492020, https://openalex.org/W4327905879, https://openalex.org/W3097937851, https://openalex.org/W4324055498, https://openalex.org/W4396921522, https://openalex.org/W2566700840, https://openalex.org/W2281703724, https://openalex.org/W2973014593, https://openalex.org/W2981585706, https://openalex.org/W2966267271, https://openalex.org/W4400090778, https://openalex.org/W2908930063, https://openalex.org/W2171783221, https://openalex.org/W2550568864, https://openalex.org/W4321104924, https://openalex.org/W4301600652, https://openalex.org/W3190803905, https://openalex.org/W4281920588, https://openalex.org/W2517538254, https://openalex.org/W2990276791, https://openalex.org/W3041927140, https://openalex.org/W4393203359, https://openalex.org/W4396943616, https://openalex.org/W2098326759, https://openalex.org/W2098944849, https://openalex.org/W3006653136, https://openalex.org/W2179438025, https://openalex.org/W4400735087, https://openalex.org/W2159707944, https://openalex.org/W3190757032, https://openalex.org/W3198945789, https://openalex.org/W3123923504, https://openalex.org/W4376136225, https://openalex.org/W3044248457 |
| referenced_works_count | 60 |
| abstract_inverted_index.3 | 118 |
| abstract_inverted_index.a | 5 |
| abstract_inverted_index.We | 47 |
| abstract_inverted_index.at | 83 |
| abstract_inverted_index.by | 9 |
| abstract_inverted_index.in | 20, 44, 123, 133, 152, 159 |
| abstract_inverted_index.is | 4 |
| abstract_inverted_index.of | 11, 39, 148 |
| abstract_inverted_index.on | 144 |
| abstract_inverted_index.to | 25, 35 |
| abstract_inverted_index.CCM | 45, 58, 94, 125 |
| abstract_inverted_index.and | 69, 76, 86, 102, 128, 135, 155 |
| abstract_inverted_index.are | 23, 33 |
| abstract_inverted_index.our | 140 |
| abstract_inverted_index.the | 37, 84, 99, 111, 145, 156 |
| abstract_inverted_index.was | 120, 130 |
| abstract_inverted_index.Upon | 89 |
| abstract_inverted_index.from | 55 |
| abstract_inverted_index.gene | 117 |
| abstract_inverted_index.into | 91, 98 |
| abstract_inverted_index.stem | 52 |
| abstract_inverted_index.that | 110 |
| abstract_inverted_index.this | 129 |
| abstract_inverted_index.with | 57, 59, 73 |
| abstract_inverted_index.(CCM) | 3 |
| abstract_inverted_index.KRIT1 | 16, 41, 61, 149 |
| abstract_inverted_index.blood | 14 |
| abstract_inverted_index.brain | 27, 92 |
| abstract_inverted_index.cells | 22, 53, 79, 96, 154 |
| abstract_inverted_index.human | 30 |
| abstract_inverted_index.known | 24 |
| abstract_inverted_index.light | 143 |
| abstract_inverted_index.sheds | 142 |
| abstract_inverted_index.study | 141 |
| abstract_inverted_index.three | 49 |
| abstract_inverted_index.(PEG3) | 119 |
| abstract_inverted_index.cells, | 127 |
| abstract_inverted_index.highly | 121 |
| abstract_inverted_index.leaky, | 12 |
| abstract_inverted_index.marker | 114 |
| abstract_inverted_index.models | 32 |
| abstract_inverted_index.needed | 34 |
| abstract_inverted_index.normal | 100 |
| abstract_inverted_index.showed | 109 |
| abstract_inverted_index.unveil | 36 |
| abstract_inverted_index.(iPSCs) | 54 |
| abstract_inverted_index.Lastly, | 106 |
| abstract_inverted_index.created | 103 |
| abstract_inverted_index.disease | 7 |
| abstract_inverted_index.further | 131 |
| abstract_inverted_index.induced | 50 |
| abstract_inverted_index.levels. | 88 |
| abstract_inverted_index.trigger | 26 |
| abstract_inverted_index.Cerebral | 0 |
| abstract_inverted_index.Overall, | 139 |
| abstract_inverted_index.abnormal | 70 |
| abstract_inverted_index.analysis | 108 |
| abstract_inverted_index.clusters | 10 |
| abstract_inverted_index.familial | 134 |
| abstract_inverted_index.germline | 40 |
| abstract_inverted_index.however, | 29 |
| abstract_inverted_index.patients | 56 |
| abstract_inverted_index.sporadic | 136 |
| abstract_inverted_index.vascular | 71, 104 |
| abstract_inverted_index.vessels. | 15 |
| abstract_inverted_index.biopsies. | 138 |
| abstract_inverted_index.cavernoma | 137, 160 |
| abstract_inverted_index.cavernous | 1 |
| abstract_inverted_index.confirmed | 132 |
| abstract_inverted_index.displayed | 80 |
| abstract_inverted_index.exhibited | 67 |
| abstract_inverted_index.explants, | 93 |
| abstract_inverted_index.expressed | 116, 122 |
| abstract_inverted_index.generated | 48 |
| abstract_inverted_index.injection | 90 |
| abstract_inverted_index.intricate | 68 |
| abstract_inverted_index.molecular | 146 |
| abstract_inverted_index.mutations | 19, 43, 151 |
| abstract_inverted_index.organoids | 66 |
| abstract_inverted_index.potential | 157 |
| abstract_inverted_index.anomalies. | 105 |
| abstract_inverted_index.bi-allelic | 17 |
| abstract_inverted_index.hereditary | 60 |
| abstract_inverted_index.importance | 38 |
| abstract_inverted_index.integrated | 97 |
| abstract_inverted_index.junctional | 85 |
| abstract_inverted_index.mutations. | 63 |
| abstract_inverted_index.paternally | 115 |
| abstract_inverted_index.phenotypic | 81 |
| abstract_inverted_index.progenitor | 113 |
| abstract_inverted_index.structures | 72 |
| abstract_inverted_index.cavernomas; | 28 |
| abstract_inverted_index.consequence | 147 |
| abstract_inverted_index.endothelial | 21, 78, 95, 112, 126, 153 |
| abstract_inverted_index.morphology, | 75 |
| abstract_inverted_index.pluripotent | 51 |
| abstract_inverted_index.preclinical | 31 |
| abstract_inverted_index.vasculature | 101 |
| abstract_inverted_index.heterozygous | 42, 62, 150 |
| abstract_inverted_index.iPSC-derived | 77, 124 |
| abstract_inverted_index.implications | 158 |
| abstract_inverted_index.malformation | 2 |
| abstract_inverted_index.vascularized | 65 |
| abstract_inverted_index.abnormalities | 82 |
| abstract_inverted_index.distinguished | 8 |
| abstract_inverted_index.mulberry-like | 13 |
| abstract_inverted_index.neurovascular | 6 |
| abstract_inverted_index.pathogenesis. | 46, 161 |
| abstract_inverted_index.cavernoma-like | 74 |
| abstract_inverted_index.Patient-derived | 64 |
| abstract_inverted_index.transcriptional | 87, 107 |
| abstract_inverted_index.loss-of-function | 18 |
| cited_by_percentile_year | |
| countries_distinct_count | 4 |
| institutions_distinct_count | 22 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/2 |
| sustainable_development_goals[0].score | 0.4699999988079071 |
| sustainable_development_goals[0].display_name | Zero hunger |
| citation_normalized_percentile.value | 0.19556801 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |