Trends in Sciences • Vol 23 • No 1
L-Ascorbic Acid (LAA) Supplementation Enhances Proliferation and Reduces Cellular Senescence in Adipose-Tissue Mesenchymal Stem Cells (AT-MSC) Without Altering Characterization
October 2025 • Komang Ardi Wahyuningsih, I Gede Eka Wiratnaya, I Wayan Wwta, I Gede Raka Widiana, Wimpie Pangkahila, Ida Ayu Ika Wahyuniari, I Made Muliarta, Veroni…
Adipose-tissue mesenchymal stem cells (AT-MSCs) and their secretome have been widely utilized in the field of anti-aging and regenerative medicine. However, the number of AT-MSCs declines during subculture due to cellular senescence. The addition of antioxidant such as L-ascorbic acid (LAA), which has been shown to promote proliferation and differentiation while reducing oxidative stress, may help mitigate cellular senescence. Nevertheless, the optimal dose of LAA supplementation for AT- MSC culture remains unclea…