L-Lysine-Modified pNIPAm-co-GMA Copolymer Hydrogel for pH- and Temperature-Responsive Drug Delivery and Fluorescence Imaging Applications Article Swipe
Madhappan Santhamoorthy
,
V. Ramkumar
,
Kokila Thirupathi
,
Selvakumari Ulagesan
,
Taek‐Jeong Nam
,
Thi Tuong Vy Phan
,
Seong‐Cheol Kim
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/gels9050363
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/gels9050363
The development of dual-stimuli-responsive hydrogels attracts much research interest owing to its unique stimuli-responsive characteristics. In this study, a poly-N-isopropyl acrylamide-co-glycidyl methacrylate-based copolymer was synthesized by incorporating N-isopropyl acrylamide (NIPAm) and a glycidyl methacrylate (GMA) monomer. The synthesized copolymer, pNIPAm-co-GMA was further modified with L-lysine (Lys) functional units and further conjugated with fluorescent isothiocyanate (FITC) to produce a fluorescent copolymer pNIPAAm-co-GMA-Lys hydrogel (HG). The in vitro drug loading and dual pH- and temperature-stimuli-responsive drug release behavior of the pNIPAAm-co-GMA-Lys HG was investigated at different pH (pH 7.4, 6.2, and 4.0) and temperature (25 °C, 37 °C, and 45 °C) conditions, respectively, using curcumin (Cur) as a model anticancer drug. The Cur drug-loaded pNIPAAm-co-GMA-Lys/Cur HG showed a relatively slow drug release behavior at a physiological pH (pH 7.4) and low temperature (25 °C) condition, whereas enhanced drug release was achieved at acidic pH (pH 6.2 and 4.0) and higher temperature (37 °C and 45 °C) conditions. Furthermore, the in vitro biocompatibility and intracellular fluorescence imaging were examined using the MDA-MB-231 cell line. Therefore, we demonstrate that the synthesized pNIPAAm-co-GMA-Lys HG system with temperature- and pH-stimuli-responsive features could be promising for various applications in biomedical fields, including drug delivery, gene delivery, tissue engineering, diagnosis, antibacterial/antifouling material, and implantable devices.
Related Topics
Concepts
Glycidyl methacrylate
Copolymer
Biocompatibility
Acrylamide
Drug delivery
Methacrylate
Self-healing hydrogels
Chemistry
Monomer
Nuclear chemistry
Materials science
Polymer chemistry
Polymer
Organic chemistry
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/gels9050363
- https://www.mdpi.com/2310-2861/9/5/363/pdf?version=1682472118
- OA Status
- gold
- Cited By
- 15
- References
- 52
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4367052329
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4367052329Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/gels9050363Digital Object Identifier
- Title
-
L-Lysine-Modified pNIPAm-co-GMA Copolymer Hydrogel for pH- and Temperature-Responsive Drug Delivery and Fluorescence Imaging ApplicationsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
-
2023-04-25Full publication date if available
- Authors
-
Madhappan Santhamoorthy, V. Ramkumar, Kokila Thirupathi, Selvakumari Ulagesan, Taek‐Jeong Nam, Thi Tuong Vy Phan, Seong‐Cheol KimList of authors in order
- Landing page
-
https://doi.org/10.3390/gels9050363Publisher landing page
- PDF URL
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https://www.mdpi.com/2310-2861/9/5/363/pdf?version=1682472118Direct link to full text PDF
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.mdpi.com/2310-2861/9/5/363/pdf?version=1682472118Direct OA link when available
- Concepts
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Glycidyl methacrylate, Copolymer, Biocompatibility, Acrylamide, Drug delivery, Methacrylate, Self-healing hydrogels, Chemistry, Monomer, Nuclear chemistry, Materials science, Polymer chemistry, Polymer, Organic chemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
15Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 7, 2024: 5, 2023: 3Per-year citation counts (last 5 years)
- References (count)
-
52Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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