Label-free detection of conformational changes in switchable DNA nanostructures with microwave microfluidics Article Swipe
Angela C. Stelson
,
Minghui Liu
,
Charles A. E. Little
,
Christian J. Long
,
Nathan D. Orloff
,
Nicholas Stephanopoulos
,
James C. Booth
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1038/s41467-019-09017-z
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1038/s41467-019-09017-z
Detection of conformational changes in biomolecular assemblies provides critical information into biological and self-assembly processes. State-of-the-art in situ biomolecular conformation detection techniques rely on fluorescent labels or protein-specific binding agents to signal conformational changes. Here, we present an on-chip, label-free technique to detect conformational changes in a DNA nanomechanical tweezer structure with microwave microfluidics. We measure the electromagnetic properties of suspended DNA tweezer solutions from 50 kHz to 110 GHz and directly detect two distinct conformations of the structures. We develop a physical model to describe the electrical properties of the tweezers, and correlate model parameters to conformational changes. The strongest indicator for conformational changes in DNA tweezers are the ionic conductivity, while shifts in the magnitude of the cooperative water relaxation indicate the addition of fuel strands used to open the tweezer. Microwave microfluidic detection of conformational changes is a generalizable, non-destructive technique, making it attractive for high-throughput measurements.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41467-019-09017-z
- https://www.nature.com/articles/s41467-019-09017-z.pdf
- OA Status
- gold
- Cited By
- 42
- References
- 71
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2921575455
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2921575455Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1038/s41467-019-09017-zDigital Object Identifier
- Title
-
Label-free detection of conformational changes in switchable DNA nanostructures with microwave microfluidicsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2019Year of publication
- Publication date
-
2019-03-12Full publication date if available
- Authors
-
Angela C. Stelson, Minghui Liu, Charles A. E. Little, Christian J. Long, Nathan D. Orloff, Nicholas Stephanopoulos, James C. BoothList of authors in order
- Landing page
-
https://doi.org/10.1038/s41467-019-09017-zPublisher landing page
- PDF URL
-
https://www.nature.com/articles/s41467-019-09017-z.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.nature.com/articles/s41467-019-09017-z.pdfDirect OA link when available
- Concepts
-
Microfluidics, Optical tweezers, Conformational change, Nanotechnology, Biophysics, Relaxation (psychology), DNA, Chemical physics, Tweezers, Materials science, Chemistry, Physics, Biology, Biochemistry, Quantum mechanics, Neuroscience, Physical chemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
42Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 7, 2024: 2, 2023: 6, 2022: 10, 2021: 7Per-year citation counts (last 5 years)
- References (count)
-
71Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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