Labelling and optical erasure of synaptic memory traces in the motor cortex Article Swipe
Akiko Hayashi‐Takagi
,
Sho Yagishita
,
Mayumi Nakamura
,
Fukutoshi Shirai
,
Yi Wu
,
Amanda L. Loshbaugh
,
Brian Kuhlman
,
Klaus M. Hahn
,
Haruo Kasai
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.17615/h8tm-ww07
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.17615/h8tm-ww07
Dendritic spines are the major loci of synaptic plasticity and are considered as possible structural correlates of memory. Nonetheless, systematic manipulation of specific subsets of spines in the cortex has been unattainable, and thus, the link between spines and memory has been correlational. We developed a novel synaptic optoprobe, AS-PaRac1 (activated synapse targeting photoactivatable Rac1), which can label recently potentiated spines specifically, and induce the selective shrinkage of AS-PaRac1-containing spines. In vivo imaging of AS-PaRac1 revealed that a motor learning induced substantial synaptic remodelling in a small subset of neurons. The acquired motor learning was disrupted by the optical shrinkage of the potentiated spines, whereas it was not affected by the identical manipulation of spines evoked by a distinct motor task in the same cortical region. Taken together, our results demonstrate that a newly acquired motor skill depends on the formation of a task-specific dense synaptic ensemble.
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https://doi.org/10.17615/h8tm-ww07Digital Object Identifier
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Labelling and optical erasure of synaptic memory traces in the motor cortexWork title
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articleOpenAlex work type
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enPrimary language
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2021Year of publication
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2021-07-01Full publication date if available
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Akiko Hayashi‐Takagi, Sho Yagishita, Mayumi Nakamura, Fukutoshi Shirai, Yi Wu, Amanda L. Loshbaugh, Brian Kuhlman, Klaus M. Hahn, Haruo KasaiList of authors in order
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https://doi.org/10.17615/h8tm-ww07Publisher landing page
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://doi.org/10.17615/h8tm-ww07Direct OA link when available
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Erasure, Neuroscience, Motor cortex, Computer science, Psychology, Programming language, StimulationTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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