Lactate supports a metabolic-epigenetic link in macrophage polarization Article Swipe

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Jordan T. Noe , Beatriz E. Rendon , Anne E. Geller , Lindsey R. Conroy , Samantha M. Morrissey , Lyndsay E.A. Young , Ronald C. Bruntz , Eun J. Kim , Ashley D. Wise , Mariana Barbosa de Souza Rizzo , Eric R. Relich , Becca V. Baby , Lance A. Johnson , Hayley C. Affronti , Kelly M. McMasters , Brian F. Clem , Matthew S. Gentry , Jun Yan , Kathryn E. Wellen , Ramon C. Sun , Robert A. Mitchell ·

YOU? · · 2021 · Open Access · · DOI: https://doi.org/10.1126/sciadv.abi8602

Macrophages use mitochondrial lactate metabolism for ACLY-dependent histone acetylation, immune suppression, and tumor progression.

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Macrophage polarization Epigenetics Acetylation Histone Immune system Macrophage Biology Mitochondrion Metabolism Cell biology Chemistry Biochemistry Immunology Gene In vitro

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Type: article
Language: en
Landing Page: https://doi.org/10.1126/sciadv.abi8602
PDF: https://www.science.org/doi/pdf/10.1126/sciadv.abi8602?download=true
OA Status: gold
Cited By: 201
References: 49
Related Works: 10
OpenAlex ID: https://openalex.org/W3214672543

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DOI: https://doi.org/10.1126/sciadv.abi8602

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Title: Lactate supports a metabolic-epigenetic link in macrophage polarization

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Type: article

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Language: en

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Publication year: 2021

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Publication date: 2021-11-12

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Authors: Jordan T. Noe, Beatriz E. Rendon, Anne E. Geller, Lindsey R. Conroy, Samantha M. Morrissey, Lyndsay E.A. Young, Ronald C. Bruntz, Eun J. Kim, Ashley D. Wise, Mariana Barbosa de Souza Rizzo, Eric R. Relich, Becca V. Baby, Lance A. Johnson, Hayley C. Affronti, Kelly M. McMasters, Brian F. Clem, Matthew S. Gentry, Jun Yan, Kathryn E. Wellen, Ramon C. Sun, Robert A. Mitchell

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Landing page: https://doi.org/10.1126/sciadv.abi8602

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Concepts: Macrophage polarization, Epigenetics, Acetylation, Histone, Immune system, Macrophage, Biology, Mitochondrion, Metabolism, Cell biology, Chemistry, Biochemistry, Immunology, Gene, In vitro

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Cited by: 201

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Citations by year (recent): 2025: 89, 2024: 41, 2023: 46, 2022: 23, 2021: 2

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cited_by_percentile_year.min	93
corresponding_author_ids	https://openalex.org/A5003848548, https://openalex.org/A5032705441
countries_distinct_count	1
institutions_distinct_count	21
corresponding_institution_ids	https://openalex.org/I142740786, https://openalex.org/I143302722, https://openalex.org/I2802239656
sustainable_development_goals[0].id	https://metadata.un.org/sdg/3
sustainable_development_goals[0].score	0.5799999833106995
sustainable_development_goals[0].display_name	Good health and well-being
citation_normalized_percentile.value	0.9882505
citation_normalized_percentile.is_in_top_1_percent	True
citation_normalized_percentile.is_in_top_10_percent	True