Large number of rebounding/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruption Article Swipe

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Meghan Rothenberger , Brandon F. Keele , Stephen W. Wietgrefe , Courtney V. Fletcher , Gregory J. Beilman , Jeffrey G. Chipman , Alexander Khoruts , Jacob D. Estes , Jodi Anderson , Samuel P. Callisto , Thomas Schmidt , Ann Thorkelson , Cavan Reilly , Katherine Perkey , Thomas Reimann , Netanya S. Utay , Krystelle Nganou Makamdop , Mario Stevenson , Daniel C. Douek , Ashley T. Haase , Timothy W. Schacker ·

YOU? · · 2015 · Open Access · · DOI: https://doi.org/10.1073/pnas.1414926112

Significance Antiretroviral therapy (ART) effectively suppresses HIV replication; however, treatment cannot be stopped, because latently infected CD4+ T cells will rekindle infection. As one estimate of the size of the pool of latently infected cells that must be purged for cure, we asked whether recrudescent infection is the result of reactivation from one or a larger number latently infected cells. We briefly stopped ART in fully suppressed patients to see how widespread new infections were in the lymphoid tissues (LTs) and how diverse rebounding/founder viruses were in peripheral blood. Recrudescent infection was detectable in multiple different LTs, and the population was genetically diverse, consistent with reactivation from a larger number of cells. These findings underscore the challenges facing strategies to eradicate HIV infection.

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Human immunodeficiency virus (HIV) Lymphatic system Medicine Virology Biology Immunology

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Type: article
Language: en
Landing Page: https://doi.org/10.1073/pnas.1414926112
PDF: https://www.pnas.org/content/pnas/112/10/E1126.full.pdf
OA Status: bronze
Cited By: 268
References: 30
Related Works: 10
OpenAlex ID: https://openalex.org/W2151758275

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OpenAlex ID: https://openalex.org/W2151758275

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DOI: https://doi.org/10.1073/pnas.1414926112

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Title: Large number of rebounding/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruption

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Type: article

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Language: en

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Publication year: 2015

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Publication date: 2015-02-23

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Authors: Meghan Rothenberger, Brandon F. Keele, Stephen W. Wietgrefe, Courtney V. Fletcher, Gregory J. Beilman, Jeffrey G. Chipman, Alexander Khoruts, Jacob D. Estes, Jodi Anderson, Samuel P. Callisto, Thomas Schmidt, Ann Thorkelson, Cavan Reilly, Katherine Perkey, Thomas Reimann, Netanya S. Utay, Krystelle Nganou Makamdop, Mario Stevenson, Daniel C. Douek, Ashley T. Haase, Timothy W. Schacker

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Landing page: https://doi.org/10.1073/pnas.1414926112

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PDF URL: https://www.pnas.org/content/pnas/112/10/E1126.full.pdf

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Open access: Yes

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OA status: bronze

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OA URL: https://www.pnas.org/content/pnas/112/10/E1126.full.pdf

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Concepts: Human immunodeficiency virus (HIV), Lymphatic system, Medicine, Virology, Biology, Immunology

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Cited by: 268

Total citation count in OpenAlex
Citations by year (recent): 2025: 17, 2024: 19, 2023: 16, 2022: 18, 2021: 22

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References (count): 30

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Related works (count): 10

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