Laser Ablation Versus Radiofrequency Ablation for Benign Non-Functioning Thyroid Nodules: Six-Month Results of a Randomized, Parallel, Open-Label, Trial (LARA Trial) Article Swipe
Roberto Cesareo
,
Claudio Maurizio Pacella
,
Valerio Pasqualini
,
Giuseppe Campagna
,
Mario Iozzino
,
Andrea Gallo
,
Angelo Lauria Pantano
,
Roberto Cianni
,
Claudio Pedone
,
Paolo Pozzilli
,
Chiara Taffon
,
Anna Crescenzi
,
Silvia Manfrini
,
Andrea Palermo
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1089/thy.2019.0660
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1089/thy.2019.0660
Background: No direct prospective studies comparing laser ablation (LA) and radiofrequency ablation (RFA) for debulking benign non-functioning thyroid nodules (BNTNs) exist. We aimed at comparing the efficacy and safety of both techniques in patients with solid or predominantly solid BNTN. Methods: This six-month, single-use, randomized, open-label, parallel trial compared the following primary endpoints between the RFA and LA groups six months after treatment: (i) nodule volume reduction expressed as a percentage of nodule volume at baseline; (ii) proportion of nodules with more than 50% reduction (successful rate). We enrolled subjects with a solitary BNTN or dominant nodule characterized by pressure symptoms/cosmetic problems or patients without symptoms who experienced a volume increase >20% in one year. Nodules underwent core needle biopsy for diagnosis. Patients were randomly assigned (1:1) to receive LA or RFA. Safety was assessed in all randomly assigned participants. Results: Sixty patients were randomly assigned to receive either RFA or LA (1:1) between January 2016 and November 2018. Both groups were similar in basal nodule volume, thyroid function, histology, symptoms/cosmetic score, and procedure time. At six months, the nodule volume reduction was 64.3% (95% confidence interval, CI 57.5-71.2) in the RFA group and 53.2% ([CI 47.2-95.2]; p = 0.02) in the LA group. This effect was also confirmed in the linear regression model adjusted for age, baseline volume, and proportion of cellular component (LA vs. RFA percent change Delta = -12.8, p = 0.02). No significant difference was observed in success rate six months after treatment (RFA vs. LA: 86.7% vs. 66.7%, p = 0.13) or in thyrotropin level between the groups. Although improved, no significant difference was observed between RFA and LA for compressive symptoms (RFA: 2.13 vs. 3.9, p < 0 · 001; LA: 2.4 vs. 3.87, p < 0.001) and cosmetic score (RFA: 1.65 vs. 2.2, p < 0.001; LA: 1.85 vs. 2.2, p < 0.001). The adverse event rates (local pain, dysphonia, thyrotoxicosis, fever, hematoma) were 37% (n = 11) and 43% (n = 13) for RFA and LA, respectively, with no requirement for hospitalization. Conclusion: Although the success rate was similar in the RFA and LA groups, RFA achieved a significantly larger nodule volume reduction at six months.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1089/thy.2019.0660
- https://www.liebertpub.com/doi/pdf/10.1089/thy.2019.0660
- OA Status
- bronze
- Cited By
- 67
- References
- 36
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3005632112
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3005632112Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1089/thy.2019.0660Digital Object Identifier
- Title
-
Laser Ablation Versus Radiofrequency Ablation for Benign Non-Functioning Thyroid Nodules: Six-Month Results of a Randomized, Parallel, Open-Label, Trial (LARA Trial)Work title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-02-14Full publication date if available
- Authors
-
Roberto Cesareo, Claudio Maurizio Pacella, Valerio Pasqualini, Giuseppe Campagna, Mario Iozzino, Andrea Gallo, Angelo Lauria Pantano, Roberto Cianni, Claudio Pedone, Paolo Pozzilli, Chiara Taffon, Anna Crescenzi, Silvia Manfrini, Andrea PalermoList of authors in order
- Landing page
-
https://doi.org/10.1089/thy.2019.0660Publisher landing page
- PDF URL
-
https://www.liebertpub.com/doi/pdf/10.1089/thy.2019.0660Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://www.liebertpub.com/doi/pdf/10.1089/thy.2019.0660Direct OA link when available
- Concepts
-
Randomized controlled trial, Ablation, Medicine, Radiofrequency ablation, Open label, Thyroid nodules, Laser ablation, Radiology, Thyroid, Laser, Surgery, Internal medicine, Optics, PhysicsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
67Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 5, 2024: 10, 2023: 9, 2022: 10, 2021: 24Per-year citation counts (last 5 years)
- References (count)
-
36Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.core | 117 |
| abstract_inverted_index.more | 81 |
| abstract_inverted_index.rate | 242, 344 |
| abstract_inverted_index.than | 82 |
| abstract_inverted_index.were | 123, 143, 161, 320 |
| abstract_inverted_index.with | 34, 80, 90, 335 |
| abstract_inverted_index.(1:1) | 126, 152 |
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| abstract_inverted_index.0.02) | 199 |
| abstract_inverted_index.0.13) | 255 |
| abstract_inverted_index.2018. | 158 |
| abstract_inverted_index.3.87, | 289 |
| abstract_inverted_index.53.2% | 194 |
| abstract_inverted_index.64.3% | 183 |
| abstract_inverted_index.86.7% | 250 |
| abstract_inverted_index.BNTN. | 39 |
| abstract_inverted_index.Delta | 229 |
| abstract_inverted_index.Sixty | 141 |
| abstract_inverted_index.after | 61, 245 |
| abstract_inverted_index.aimed | 22 |
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| abstract_inverted_index.event | 312 |
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| abstract_inverted_index.laser | 6 |
| abstract_inverted_index.level | 259 |
| abstract_inverted_index.model | 213 |
| abstract_inverted_index.pain, | 315 |
| abstract_inverted_index.rates | 313 |
| abstract_inverted_index.score | 295 |
| abstract_inverted_index.solid | 35, 38 |
| abstract_inverted_index.time. | 174 |
| abstract_inverted_index.trial | 47 |
| abstract_inverted_index.year. | 114 |
| abstract_inverted_index.(local | 314 |
| abstract_inverted_index.-12.8, | 231 |
| abstract_inverted_index.0.001) | 292 |
| abstract_inverted_index.0.001; | 302 |
| abstract_inverted_index.0.02). | 234 |
| abstract_inverted_index.66.7%, | 252 |
| abstract_inverted_index.Safety | 132 |
| abstract_inverted_index.benign | 15 |
| abstract_inverted_index.biopsy | 119 |
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| abstract_inverted_index.direct | 2 |
| abstract_inverted_index.effect | 205 |
| abstract_inverted_index.either | 148 |
| abstract_inverted_index.exist. | 20 |
| abstract_inverted_index.fever, | 318 |
| abstract_inverted_index.group. | 203 |
| abstract_inverted_index.groups | 58, 160 |
| abstract_inverted_index.larger | 357 |
| abstract_inverted_index.linear | 211 |
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| abstract_inverted_index.needle | 118 |
| abstract_inverted_index.nodule | 64, 72, 96, 165, 179, 358 |
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| abstract_inverted_index.safety | 28 |
| abstract_inverted_index.score, | 171 |
| abstract_inverted_index.volume | 65, 73, 109, 180, 359 |
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| abstract_inverted_index.0.001). | 309 |
| abstract_inverted_index.January | 154 |
| abstract_inverted_index.Nodules | 115 |
| abstract_inverted_index.adverse | 311 |
| abstract_inverted_index.between | 53, 153, 260, 270 |
| abstract_inverted_index.groups, | 352 |
| abstract_inverted_index.groups. | 262 |
| abstract_inverted_index.months, | 177 |
| abstract_inverted_index.months. | 363 |
| abstract_inverted_index.nodules | 18, 79 |
| abstract_inverted_index.percent | 227 |
| abstract_inverted_index.primary | 51 |
| abstract_inverted_index.receive | 128, 147 |
| abstract_inverted_index.similar | 162, 346 |
| abstract_inverted_index.studies | 4 |
| abstract_inverted_index.success | 241, 343 |
| abstract_inverted_index.thyroid | 17, 167 |
| abstract_inverted_index.volume, | 166, 218 |
| abstract_inverted_index.without | 104 |
| abstract_inverted_index.<i>p</i> | 197, 232, 253, 281, 290, 300, 307 |
| abstract_inverted_index.Although | 263, 341 |
| abstract_inverted_index.November | 157 |
| abstract_inverted_index.Patients | 122 |
| abstract_inverted_index.ablation | 7, 11 |
| abstract_inverted_index.achieved | 354 |
| abstract_inverted_index.adjusted | 214 |
| abstract_inverted_index.assessed | 134 |
| abstract_inverted_index.assigned | 125, 138, 145 |
| abstract_inverted_index.baseline | 217 |
| abstract_inverted_index.cellular | 222 |
| abstract_inverted_index.compared | 48 |
| abstract_inverted_index.cosmetic | 294 |
| abstract_inverted_index.dominant | 95 |
| abstract_inverted_index.efficacy | 26 |
| abstract_inverted_index.enrolled | 88 |
| abstract_inverted_index.increase | 110 |
| abstract_inverted_index.observed | 239, 269 |
| abstract_inverted_index.parallel | 46 |
| abstract_inverted_index.patients | 33, 103, 142 |
| abstract_inverted_index.pressure | 99 |
| abstract_inverted_index.problems | 101 |
| abstract_inverted_index.randomly | 124, 137, 144 |
| abstract_inverted_index.solitary | 92 |
| abstract_inverted_index.subjects | 89 |
| abstract_inverted_index.symptoms | 105, 276 |
| abstract_inverted_index.(<i>n</i> | 322, 327 |
| abstract_inverted_index.baseline; | 75 |
| abstract_inverted_index.comparing | 5, 24 |
| abstract_inverted_index.component | 223 |
| abstract_inverted_index.confirmed | 208 |
| abstract_inverted_index.debulking | 14 |
| abstract_inverted_index.endpoints | 52 |
| abstract_inverted_index.expressed | 67 |
| abstract_inverted_index.following | 50 |
| abstract_inverted_index.function, | 168 |
| abstract_inverted_index.hematoma) | 319 |
| abstract_inverted_index.improved, | 264 |
| abstract_inverted_index.interval, | 186 |
| abstract_inverted_index.procedure | 173 |
| abstract_inverted_index.reduction | 66, 84, 181, 360 |
| abstract_inverted_index.treatment | 246 |
| abstract_inverted_index.underwent | 116 |
| abstract_inverted_index.57.5-71.2) | 188 |
| abstract_inverted_index.confidence | 185 |
| abstract_inverted_index.diagnosis. | 121 |
| abstract_inverted_index.difference | 237, 267 |
| abstract_inverted_index.dysphonia, | 316 |
| abstract_inverted_index.histology, | 169 |
| abstract_inverted_index.percentage | 70 |
| abstract_inverted_index.proportion | 77, 220 |
| abstract_inverted_index.regression | 212 |
| abstract_inverted_index.six-month, | 42 |
| abstract_inverted_index.techniques | 31 |
| abstract_inverted_index.treatment: | 62 |
| abstract_inverted_index.(successful | 85 |
| abstract_inverted_index.47.2-95.2]; | 196 |
| abstract_inverted_index.compressive | 275 |
| abstract_inverted_index.experienced | 107 |
| abstract_inverted_index.open-label, | 45 |
| abstract_inverted_index.prospective | 3 |
| abstract_inverted_index.randomized, | 44 |
| abstract_inverted_index.requirement | 337 |
| abstract_inverted_index.significant | 236, 266 |
| abstract_inverted_index.single-use, | 43 |
| abstract_inverted_index.thyrotropin | 258 |
| abstract_inverted_index.characterized | 97 |
| abstract_inverted_index.participants. | 139 |
| abstract_inverted_index.predominantly | 37 |
| abstract_inverted_index.respectively, | 334 |
| abstract_inverted_index.significantly | 356 |
| abstract_inverted_index.radiofrequency | 10 |
| abstract_inverted_index.non-functioning | 16 |
| abstract_inverted_index.thyrotoxicosis, | 317 |
| abstract_inverted_index.hospitalization. | 339 |
| abstract_inverted_index.symptoms/cosmetic | 100, 170 |
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| abstract_inverted_index.<b><i>Results:</i></b> | 140 |
| abstract_inverted_index.<b><i>Background:</i></b> | 0 |
| abstract_inverted_index.<b><i>Conclusion:</i></b> | 340 |
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| countries_distinct_count | 1 |
| institutions_distinct_count | 14 |
| corresponding_institution_ids | https://openalex.org/I4210140443 |
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| citation_normalized_percentile.value | 0.980153 |
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