Abstract Widespread structural brain abnormalities have been consistently reported in schizophrenia, but their relation to the heterogeneous clinical manifestations remains unknown. In particular, it is un-clear whether anatomical abnormalities in discrete regions give rise to discrete symptoms, or whether distributed abnormalities give rise to the broad clinical profile associated with schizophrenia. Here we apply a multivariate data-driven approach to investigate covariance patterns between multiple symptom doma…