Layer-by-layer approach for a uniformed fabrication of a cell patterned vessel-like construct Article Swipe
Camila A. Wilkens
,
Christopher J. Rivet
,
Tamara L. Akentjew
,
Julian Alverio
,
Maroun Khoury
,
Juan Pablo Acevedo
·
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.1088/1758-5090/9/1/015001
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.1088/1758-5090/9/1/015001
Successful tissue engineered small diameter blood vessels (SDBV) require manufacturing systems capable of precisely controlling different key elements, such as material composition, geometry and spatial location of specialized biomaterials and cells types. We report in this work an automated methodology that enables the manufacture of multilayer cylindrical constructs for SDBV fabrication that uses a layer-by-layer deposition approach while controlling variables such as dipping and spinning speed of a rod and biomaterial viscosity. Different biomaterials including methacrylated gelatin, alginate and chitosan were tested using this procedure to build different parts of the constructs. The system was capable of controlling dimensions of lumen from 0.5 mm up to 6 mm diameter and individual layers from 1 μm up to 400 μm thick. A cellular component was successfully added to the biomaterial in the absence of significant cytotoxic effect which was assessed by viability and proliferation assays. Additionally, cells showed a homogenous distribution with well-defined concentric patterns across the multilayer vessel grafts. The challenging generation of inner endothelial cells of approximately 20-30 μm of thickness was achieved. Preliminary experimental evidences of microstructural alignment of the biomaterial were obtained when the dipping approach was combined with the rod rotation. The study demonstrated the wide versatility and scalability of the automated system to easily and rapidly fabricate complex cellularized multilayer vascular grafts with structural configuration that resembles natural blood vessels.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1088/1758-5090/9/1/015001
- https://iopscience.iop.org/article/10.1088/1758-5090/9/1/015001/pdf
- OA Status
- hybrid
- Cited By
- 40
- References
- 56
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2558803605
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2558803605Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1088/1758-5090/9/1/015001Digital Object Identifier
- Title
-
Layer-by-layer approach for a uniformed fabrication of a cell patterned vessel-like constructWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2016Year of publication
- Publication date
-
2016-12-01Full publication date if available
- Authors
-
Camila A. Wilkens, Christopher J. Rivet, Tamara L. Akentjew, Julian Alverio, Maroun Khoury, Juan Pablo AcevedoList of authors in order
- Landing page
-
https://doi.org/10.1088/1758-5090/9/1/015001Publisher landing page
- PDF URL
-
https://iopscience.iop.org/article/10.1088/1758-5090/9/1/015001/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://iopscience.iop.org/article/10.1088/1758-5090/9/1/015001/pdfDirect OA link when available
- Concepts
-
Biomaterial, Materials science, Biomedical engineering, Fabrication, Gelatin, Layer (electronics), Tissue engineering, Nanotechnology, Engineering drawing, Chemistry, Engineering, Biochemistry, Medicine, Pathology, Alternative medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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40Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3, 2024: 1, 2023: 5, 2022: 1, 2021: 8Per-year citation counts (last 5 years)
- References (count)
-
56Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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