Lead detoxification of edible fungi Auricularia auricula and Pleurotus ostreatus: the purification of the chelation substances and their effects on rats Article Swipe
Weiwei Zhang
,
Xiaojie Zheng
,
Xiangdong Chen
,
Xuezhen Jiang
,
Hexiang Wang
,
Guoqing Zhang
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3389/fnut.2023.1162110
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3389/fnut.2023.1162110
Lead is a global pollutant that causes widespread concern. When a lead enters the body, it is distributed throughout the body and accumulates in the brain, bone, and soft tissues such as the kidney, liver, and spleen. Chelators used for lead poisoning therapy all have side effects to some extent and other drawbacks including high cost. Exploration and utilization of natural antidotes become necessary. To date, few substances originating from edible fungi that are capable of adsorbing lead have been reported. In this study, we found that two commonly eaten mushrooms Auricularia auricula and Pleurotus ostreatus exhibited lead adsorption capacity. A. auricula active substance (AAAS) and P. ostreatus active substance (POAS) were purified by hot-water extraction, ethanol precipitation from its fruiting bodies followed by ion exchange chromatography, ultrafiltration, and gel filtration chromatography, respectively. AAAS was 3.6 kDa, while POAS was 4.9 kDa. They were both constituted of polysaccharides and peptides. The peptide sequences obtained by liquid chromatography combined with tandem mass spectrometry (LC-MS/MS) proved that they were rich in amino acids with side chain groups such as hydroxyl, carboxyl, carbonyl, sulfhydryl, and amidogen. Two rat models were established, but only a chronic lead-induced poisoning model was employed to determine the detoxification of AAAS/POAS and their fruiting body powder. For rats receiving continuous lead treatment, either AAAS or POAS could reduce the lead levels in the blood. They also promoted the elimination of the burden of lead in the spleen and kidney. The fruiting bodies were also proved to have lead detoxification effects. This is the first study to identify new functions of A. auricula and P. ostreatus in reducing lead toxicity and to provide dietary strategies for the treatment of lead toxicity.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fnut.2023.1162110
- https://www.frontiersin.org/articles/10.3389/fnut.2023.1162110/pdf
- OA Status
- gold
- Cited By
- 8
- References
- 41
- Related Works
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4366549202Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fnut.2023.1162110Digital Object Identifier
- Title
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Lead detoxification of edible fungi Auricularia auricula and Pleurotus ostreatus: the purification of the chelation substances and their effects on ratsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-04-20Full publication date if available
- Authors
-
Weiwei Zhang, Xiaojie Zheng, Xiangdong Chen, Xuezhen Jiang, Hexiang Wang, Guoqing ZhangList of authors in order
- Landing page
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https://doi.org/10.3389/fnut.2023.1162110Publisher landing page
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https://www.frontiersin.org/articles/10.3389/fnut.2023.1162110/pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.frontiersin.org/articles/10.3389/fnut.2023.1162110/pdfDirect OA link when available
- Concepts
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Pleurotus ostreatus, Chemistry, Detoxification (alternative medicine), Food science, Chromatography, Mushroom, Medicine, Pathology, Alternative medicineTop concepts (fields/topics) attached by OpenAlex
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8Total citation count in OpenAlex
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2025: 6, 2024: 2Per-year citation counts (last 5 years)
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41Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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