Leaf Extracts of Cistus ladanifer Exhibit Potent Antioxidant and Antiproliferative Activities against Liver, Prostate and Breast Cancer Cells Article Swipe
Kaoutar Bouothmany
,
Mohammed Bourhia
,
Noura Aoussar
,
Mohammed Attaleb
,
Ahmad Mohammad Salamatullah
,
Hiba‐Allah Nafidi
,
Fouad Mellouki
,
Mohammed El Mzibri
,
Mourad A. M. Aboul‐Soud
,
Laïla Benbacer
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/app12178603
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/app12178603
Chemical composition, antioxidant, and antiproliferative properties of C. ladanifer crude extracts, including hexane (Hex), dichloromethane (DCM), ethyl acetate (E.A) and ethanol (EtOH) were investigated. The chemical composition of C. ladanifer crude extracts was determined by use of GC-MS, whereas DPPH and FRAP assays were employed to determine its antioxidant capacity. The obtained results showed that the ethanolic extract exhibited a significant antioxidant effect recording an IC50 value of 266.6 ± 0.828 μg/mL with DPPH assay, and a higher reducing power 0.494 ± 0.035 using the FRAP test. The extracts exhibited significant antiproliferative activity against three cancer cell lines. The DCM extract exhibited the highest total polyphenol content (76.066 ± 9.978 μg AGE/mg) and was revealed to be more effective against HepG2 (31.54 ± 0.242 μg/mL). The Hex extract that presented the highest flavonoid content (50.209 ± 3.805 μg CE/mg) exhibited the highest antiproliferative activity against 22Rv1 and MDA-MB-231 recording IC50 values 11.32 ± 2.126 μg/mL and 82.4 ± 1.124 μg/mL, respectively. All four extracts exhibited minimal toxicity against human skin-derived fibroblast cells indicating the specificity of their observed anticancer activity. GC-MS analysis identified interesting phytochemicals underlying the obtained antioxidant and cytotoxic activities. Taken together, results of the current study highlight the significance of C. ladanifer as a valuable source of antioxidant and anticancer bioactive compounds, thereby warranting further detailed investigation.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/app12178603
- https://www.mdpi.com/2076-3417/12/17/8603/pdf?version=1667372147
- OA Status
- gold
- Cited By
- 10
- References
- 38
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4293415082
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4293415082Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/app12178603Digital Object Identifier
- Title
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Leaf Extracts of Cistus ladanifer Exhibit Potent Antioxidant and Antiproliferative Activities against Liver, Prostate and Breast Cancer CellsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-08-27Full publication date if available
- Authors
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Kaoutar Bouothmany, Mohammed Bourhia, Noura Aoussar, Mohammed Attaleb, Ahmad Mohammad Salamatullah, Hiba‐Allah Nafidi, Fouad Mellouki, Mohammed El Mzibri, Mourad A. M. Aboul‐Soud, Laïla BenbacerList of authors in order
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https://doi.org/10.3390/app12178603Publisher landing page
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https://www.mdpi.com/2076-3417/12/17/8603/pdf?version=1667372147Direct link to full text PDF
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2076-3417/12/17/8603/pdf?version=1667372147Direct OA link when available
- Concepts
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DPPH, Chemistry, Antioxidant, Polyphenol, Ethyl acetate, IC50, Traditional medicine, Food science, Ethanol, Dichloromethane, Proanthocyanidin, Flavonoid, Biochemistry, Pharmacology, In vitro, Biology, Solvent, MedicineTop concepts (fields/topics) attached by OpenAlex
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10Total citation count in OpenAlex
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2025: 5, 2024: 5Per-year citation counts (last 5 years)
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38Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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