Leishmania-Derived Trimannose Modulates the Inflammatory Response To Significantly Reduce Leishmania major-Induced Lesions Article Swipe
Tara Grinnage‐Pulley
,
Daniel E. K. Kabotso
,
Chelsea L. Rintelmann
,
Rajarshi Roychoudhury
,
Robert G. Schaut
,
Angela J. Toepp
,
Katherine N. Gibson‐Corley
,
Molly Parrish
,
Nicola L. B. Pohl
,
Christine A. Petersen
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1128/iai.00672-17
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1128/iai.00672-17
Leishmania lipophosphoglycan (LPG) is a key virulence factor, initiating inflammation resulting in cutaneous lesions. LPG is capped by various oligosaccharides. How these glycans are recognized and how they alter the course of Leishmania infection are poorly understood. Previous studies synthesized α-1,2-trimannose cap sugars on latex beads and demonstrated that C57BL/6 mice coinoculated with Leishmania major and trimannose-coated beads produced significantly higher levels of interleukin-12p40 (IL-12p40) and other proinflammatory, type 1 cytokines than mice inoculated with L. major alone within the first 48 h of infection. However, as L. major infection typically progress over weeks to months, the role of trimannose in altering disease progression over the course of infection was unknown. Wild-type mice were inoculated with either trimannose-coated or carrier (uncoated) beads, infected with L. major alone, coinoculated with carrier beads and L. major , or coinoculated with trimannose-coated beads and L. major . Trimannose treatment of L. major -infected mice decreased the parasite load and significantly decreased the lesion size at 14 days postinfection (p.i.) compared to results for nontreated, infected mice. Infected, trimannose-treated mice had decreased IL-12p40 and IL-10 secretion and increased interferon gamma secretion at 14 days p.i. Mannose receptor knockout (MR −/− ) mice lack the ability to detect trimannose. When MR −/− mice were infected with L. major and treated with trimannose beads, they did not have decreased lesion size. Leishmania -derived trimannose represents a novel immunomodulator that provides early type 1-skewed cytokine production to control the parasite load and alter the course of cutaneous leishmaniasis.
Related Topics
Concepts
Biology
Leishmania
Proinflammatory cytokine
Leishmania major
Lipophosphoglycan
Kinetoplastida
Inflammation
Cytokine
Parasite load
Microbiology
Immunology
Mannose receptor
Secretion
Interferon gamma
Leishmania mexicana
Lesion
Parasite hosting
Macrophage
Leishmania donovani
Immune system
Leishmaniasis
In vitro
Pathology
Visceral leishmaniasis
Endocrinology
Medicine
Computer science
Biochemistry
World Wide Web
Protozoal disease
Malaria
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1128/iai.00672-17
- https://iai.asm.org/content/iai/86/1/e00672-17.full.pdf
- OA Status
- bronze
- Cited By
- 4
- References
- 45
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2765088375
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2765088375Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1128/iai.00672-17Digital Object Identifier
- Title
-
Leishmania-Derived Trimannose Modulates the Inflammatory Response To Significantly Reduce Leishmania major-Induced LesionsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2017Year of publication
- Publication date
-
2017-10-24Full publication date if available
- Authors
-
Tara Grinnage‐Pulley, Daniel E. K. Kabotso, Chelsea L. Rintelmann, Rajarshi Roychoudhury, Robert G. Schaut, Angela J. Toepp, Katherine N. Gibson‐Corley, Molly Parrish, Nicola L. B. Pohl, Christine A. PetersenList of authors in order
- Landing page
-
https://doi.org/10.1128/iai.00672-17Publisher landing page
- PDF URL
-
https://iai.asm.org/content/iai/86/1/e00672-17.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://iai.asm.org/content/iai/86/1/e00672-17.full.pdfDirect OA link when available
- Concepts
-
Biology, Leishmania, Proinflammatory cytokine, Leishmania major, Lipophosphoglycan, Kinetoplastida, Inflammation, Cytokine, Parasite load, Microbiology, Immunology, Mannose receptor, Secretion, Interferon gamma, Leishmania mexicana, Lesion, Parasite hosting, Macrophage, Leishmania donovani, Immune system, Leishmaniasis, In vitro, Pathology, Visceral leishmaniasis, Endocrinology, Medicine, Computer science, Biochemistry, World Wide Web, Protozoal disease, MalariaTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
4Total citation count in OpenAlex
- Citations by year (recent)
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2024: 1, 2022: 1, 2020: 1, 2019: 1Per-year citation counts (last 5 years)
- References (count)
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45Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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