Lemongrass Alleviates Primary Dysmenorrhea Symptoms by Reducing Oxidative Stress and Inflammation and Relaxing the Uterine Muscles Article Swipe
Sheikh Safeena Sidiq
,
Qaiser Jabeen
,
QurratUlAin Jamil
,
Muhammad Saeed Jan
,
Iram Iqbal
,
Fatima Saqib
,
Mohammed Aufy
,
Shahid Muhammad Iqbal
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/antiox14070838
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/antiox14070838
Primary dysmenorrhea (PD) is characterized by lower abdominal spasms and painful cramps during menstruation in females with a normal pelvic anatomy. Cymbopogon citratus (DC.) Stapf, commonly known as lemongrass, is consumed in the form of herbal tea around the world. It has been traditionally used for menstrual disorders in several communities. This study aims to evaluate the traditional use of C. citratus for its efficacy in alleviating the symptoms of PD. C. citratus extract (CcE) was chemically characterized using HPLC and GCMS, which indicated the presence of several phenolic compounds and long-chain fatty acids. The anti-inflammatory activity of CcE was assessed by COX-I, COX-II, and 5-LOX enzyme inhibition with IC50 values of 143.7, 91.7, and 61.5 µg/mL, respectively, and showed good total antioxidant capacity and free radical scavenging activity. PD was induced in female Wistar rats by administering estradiol valerate followed by oxytocin to induce PD symptoms. CcE efficacy was assessed at 30, 100, and 300 mg/kg concentrations and compared with ibuprofen. CcE 300 mg/kg reduced abdominal contortions and inflammation in the rat uterus. The inflammatory (COX-II, TNFα and IL-10) and oxidative stress (TAC, TOS, MDA and SOD) markers in uterine tissue homogenate were also improved. An in vivo analgesic assessment through hot-plate, tail-flick, and acetic acid-induced writhing assays showed good analgesic activity by CcE, while ex vivo experiments described tocolytic effects in rat uterine muscles. CcE alleviates PD by its antioxidant, anti-inflammatory, analgesic, and tocolytic effects.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/antiox14070838
- https://www.mdpi.com/2076-3921/14/7/838/pdf?version=1751985231
- OA Status
- gold
- Cited By
- 2
- References
- 34
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4412106068
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4412106068Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/antiox14070838Digital Object Identifier
- Title
-
Lemongrass Alleviates Primary Dysmenorrhea Symptoms by Reducing Oxidative Stress and Inflammation and Relaxing the Uterine MusclesWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-07-08Full publication date if available
- Authors
-
Sheikh Safeena Sidiq, Qaiser Jabeen, QurratUlAin Jamil, Muhammad Saeed Jan, Iram Iqbal, Fatima Saqib, Mohammed Aufy, Shahid Muhammad IqbalList of authors in order
- Landing page
-
https://doi.org/10.3390/antiox14070838Publisher landing page
- PDF URL
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https://www.mdpi.com/2076-3921/14/7/838/pdf?version=1751985231Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2076-3921/14/7/838/pdf?version=1751985231Direct OA link when available
- Concepts
-
Oxidative stress, Cymbopogon citratus, Medicine, Antioxidant, Analgesic, Tocolytic, Uterus, Pharmacology, In vivo, Ex vivo, Ibuprofen, Internal medicine, Endocrinology, Chemistry, Fetus, Essential oil, Biochemistry, Pregnancy, Food science, Genetics, Biology, Biotechnology, Preterm laborTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
2Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2Per-year citation counts (last 5 years)
- References (count)
-
34Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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