Leptin-Induced Endothelium-Independent Vasoconstriction in Thoracic Aorta and Pulmonary Artery of Spontaneously Hypertensive Rats: Role of Calcium Channels and Stores Article Swipe
Samantha Gomart
,
Caroline Gaudreau-Ménard
,
Pascale Jespers
,
Ömer Gürkan Dilek
,
Emeline Hupkens
,
Aliénor Hanthazi
,
Robert Naeije
,
Christian Mélot
,
Nathalie Labranche
,
Laurence Dewachter
,
Kathleen Mc Entee
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pone.0169205
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pone.0169205
Decreased leptin-induced endothelium-dependent vasodilation has been reported in spontaneously hypertensive rats (SHR). Here, we report leptin-induced vasoconstriction in endothelium-denuded pulmonary artery and thoracic aorta from SHR and sought to characterize calcium handling underlying these mechanisms. Vasoreactivity to leptin was evaluated on pulmonary artery and thoracic aorta rings from 18 weeks old male SHR with or without calcium free medium, caffeine + thapsigargin + carbonyl cyanide-4-trifluoromethoxyphenylhydrazone emptying intracellular calcium stores, nifedipine a voltage-gated calcium channel inhibitor, SKF-96365 a transient receptor potential cation channels (TRPC) inhibitor, wortmaninn, a phosphatidylinositide 3-kinases (PI3K) inhibitor, or PD98059 a mitogen-activated protein kinase kinase (MAPKK) inhibitor. Calcium imaging was performed on cultured vascular smooth muscle cells incubated with leptin in presence or not of wortmaninn or PD98059. Leptin induced vasoconstriction in denuded pulmonary artery and thoracic aorta from SHR. Response was abolished when intra- or extracellular calcium stores were emptied, after blocking TRPC or voltage-dependent calcium channels or when using MAPKK or PI3K inhibitors. In vascular smooth muscle cells, leptin increased intracellular calcium. This rise was higher in SHR and abolished by MAPKK or PI3K inhibitors. TRPC6 gene expression was upregulated in arteries from SHR. Leptin-induced vasoconstriction in denuded arteries of SHR requires intracellular stores and is TRPC- and voltage-gated calcium channels dependent. Intracellular calcium increase is more pronounced in spontaneously hypertensive rats.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1371/journal.pone.0169205
- https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0169205&type=printable
- OA Status
- gold
- Cited By
- 14
- References
- 55
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2571813397
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- OpenAlex ID
-
https://openalex.org/W2571813397Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1371/journal.pone.0169205Digital Object Identifier
- Title
-
Leptin-Induced Endothelium-Independent Vasoconstriction in Thoracic Aorta and Pulmonary Artery of Spontaneously Hypertensive Rats: Role of Calcium Channels and StoresWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2017Year of publication
- Publication date
-
2017-01-13Full publication date if available
- Authors
-
Samantha Gomart, Caroline Gaudreau-Ménard, Pascale Jespers, Ömer Gürkan Dilek, Emeline Hupkens, Aliénor Hanthazi, Robert Naeije, Christian Mélot, Nathalie Labranche, Laurence Dewachter, Kathleen Mc EnteeList of authors in order
- Landing page
-
https://doi.org/10.1371/journal.pone.0169205Publisher landing page
- PDF URL
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0169205&type=printableDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0169205&type=printableDirect OA link when available
- Concepts
-
Endocrinology, Internal medicine, TRPC, Calcium in biology, Vasoconstriction, Thapsigargin, Calcium channel, Vascular smooth muscle, Voltage-dependent calcium channel, Calcium, Chemistry, Medicine, Transient receptor potential channel, Receptor, Smooth muscleTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
14Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 1, 2023: 1, 2022: 1, 2021: 2, 2020: 1Per-year citation counts (last 5 years)
- References (count)
-
55Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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