Lessons from the CONSCIOUS-1 Study Article Swipe
Alexander J. Schüpper
,
Matthew E. Eagles
,
Sean N. Neifert
,
J Mocco
,
R. Loch Macdonald
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3390/jcm9092970
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3390/jcm9092970
After years of research on treatment of aneurysmal subarachnoid hemorrhage (aSAH), including randomized clinical trials, few treatments have been shown to be efficacious. Nevertheless, reductions in morbidity and mortality have occurred over the last decades. Reasons for the improved outcomes remain unclear. One randomized clinical trial that has been examined in detail with these questions in mind is Clazosentan to Overcome Neurological Ischemia and Infarction Occurring After Subarachnoid Hemorrhage (CONSCIOUS-1). This was a phase-2 trial testing the effect of clazosentan on angiographic vasospasm (aVSP) in patients with aSAH. Clazosentan decreased moderate to severe aVSP. There was no statistically significant effect on the extended Glasgow outcome score (GOS), although the study was not powered for this endpoint. Data from the approximately 400 patients in the study were detailed, rigorously collected and documented and were generously made available to one investigator. Post-hoc analyses were conducted which have expanded our knowledge of the management of aSAH. We review those analyses here.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/jcm9092970
- https://www.mdpi.com/2077-0383/9/9/2970/pdf?version=1600088173
- OA Status
- gold
- Cited By
- 15
- References
- 127
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3085528921
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3085528921Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/jcm9092970Digital Object Identifier
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Lessons from the CONSCIOUS-1 StudyWork title
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
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2020-09-14Full publication date if available
- Authors
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Alexander J. Schüpper, Matthew E. Eagles, Sean N. Neifert, J Mocco, R. Loch MacdonaldList of authors in order
- Landing page
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https://doi.org/10.3390/jcm9092970Publisher landing page
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https://www.mdpi.com/2077-0383/9/9/2970/pdf?version=1600088173Direct link to full text PDF
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2077-0383/9/9/2970/pdf?version=1600088173Direct OA link when available
- Concepts
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Medicine, Subarachnoid hemorrhage, Randomized controlled trial, Vasospasm, Post-hoc analysis, Glasgow Outcome Scale, Clinical trial, Anesthesia, Internal medicine, Glasgow Coma ScaleTop concepts (fields/topics) attached by OpenAlex
- Cited by
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15Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 5, 2022: 5, 2021: 3, 2020: 1Per-year citation counts (last 5 years)
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127Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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