Level of Amyloid-β (Aβ) Binding Leading to Differential Effects on Resting State Functional Connectivity in Major Brain Networks Article Swipe
Eva YW Cheung
,
Anson C.M. Chau
,
Yat Fung Shea
,
Patrick Chiu
,
Joseph Kwan
,
Henry Ka‐Fung Mak
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/biomedicines10092321
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/biomedicines10092321
Introduction: Amyloid-β protein (Aβ) is one of the biomarkers for Alzheimer’s disease (AD). The recent application of interhemispheric functional connectivity (IFC) in resting-state fMRI has been used as a non-invasive diagnostic tool for early dementia. In this study, we focused on the level of Aβ accumulated and its effects on the major functional networks, including default mode network (DMN), central executive network (CEN), salience network (SN), self-referential network (SRN) and sensory motor network (SMN). Methods: 58 participants (27 Hi Aβ (HiAmy) and 31 low Aβ (LowAmy)) and 25 healthy controls (HC) were recruited. [18F]flutemetamol PET/CT was performed for diseased groups, and MRI scanning was done for all participants. Voxel-by-voxel correlation analysis was done for both groups in all networks. Results: In HiAmy, IFC was reduced in all networks except SN. A negative correlation in DMN, CEN, SRN and SMN suggests high Aβ related to IFC reduction; However, a positive correlation in SN suggests high Aβ related to an increase in IFC. In LowAmy, IFC increased in CEN, SMN, SN and SRN. Positive correlation in all major brain networks. Conclusion: The level of Aβ accumulated demonstrated differential effects on IFC in various brain networks. As the treatment to reduce Aβ plaque deposition is available in the market, it may be an option for the HiAmy group to improve their IFC in major brain networks.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/biomedicines10092321
- https://www.mdpi.com/2227-9059/10/9/2321/pdf?version=1663574242
- OA Status
- gold
- Cited By
- 6
- References
- 67
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4296350758
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4296350758Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/biomedicines10092321Digital Object Identifier
- Title
-
Level of Amyloid-β (Aβ) Binding Leading to Differential Effects on Resting State Functional Connectivity in Major Brain NetworksWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-09-19Full publication date if available
- Authors
-
Eva YW Cheung, Anson C.M. Chau, Yat Fung Shea, Patrick Chiu, Joseph Kwan, Henry Ka‐Fung MakList of authors in order
- Landing page
-
https://doi.org/10.3390/biomedicines10092321Publisher landing page
- PDF URL
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https://www.mdpi.com/2227-9059/10/9/2321/pdf?version=1663574242Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2227-9059/10/9/2321/pdf?version=1663574242Direct OA link when available
- Concepts
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Default mode network, Resting state fMRI, Neuroscience, Voxel, Dementia, Correlation, Salience (neuroscience), Medicine, Psychology, Functional connectivity, Disease, Pathology, Radiology, Mathematics, GeometryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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6Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 3, 2023: 2Per-year citation counts (last 5 years)
- References (count)
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67Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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