Levodopa/carbidopa/entacapone versus levodopa/benserazide plus pramipexole in Chinese patients with Parkinson’s disease experiencing wearing off Article Swipe
Weiguo Liu
,
Min Ye
,
Yang Zhao
,
Xueling Zhang
,
Xianwen Chen
,
Lihua Shen
,
Dan Li
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fneur.2025.1682614
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fneur.2025.1682614
Objective To compare the efficacy and safety of direct switch from levodopa/benserazide (LB) to levodopa/carbidopa/entacapone (LCE) versus LB plus pramipexole (PPX) in Chinese patients with Parkinson’s disease (PD) experiencing wearing off (WO). Methods In this multicenter, prospective, randomized, open-label, observational study, 140 patients with PD experiencing WO who had been on stable LB treatment were enrolled and randomized 3:2 to receive LCE (84) or LB + PPX (56) treatment for 8 weeks. The primary endpoint was change in the daily “OFF” time from baseline. Change in the daily “ON” time was also assessed. Treatment-emergent adverse events (TEAEs) were recorded. Results Seventy-nine patients in the LCE group and 49 patients in the PPX group completed the study. Both LCE and PPX shortened the patients’ daily OFF time significantly after 8 weeks (−1.76 ± 1.70 h, p < 0.001 and −1.51 ± 1.60, p < 0.001, respectively), and the shortenings were comparable between the two groups ( p = 0.414). Correspondingly, both the LCE group and the PPX group had significantly increased daily ON time (1.62 ± 1.59 h, p < 0.001 and 1.38 ± 1.65, p < 0.001, respectively), and the increases were comparable between the two groups ( p = 0.412). Both treatments improved the patients’ WO symptoms, sleep quality, depression and quality of life. Six (7.59%) patients in the LCE group and 7 (14.29%) patients in the PPX group reported TEAEs, all of which were mild and tolerable. One patient in the LCE group and 2 patients in the PPX group experienced mild dyskinesia. Conclusion LCE and LB + PPX were both effective, safe and tolerable in treating patients with PD who experienced WO.
Related Topics
Concepts
No concepts available.
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fneur.2025.1682614
- https://public-pages-files-2025.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1682614/pdf
- OA Status
- gold
- References
- 42
- OpenAlex ID
- https://openalex.org/W4416404650
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4416404650Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fneur.2025.1682614Digital Object Identifier
- Title
-
Levodopa/carbidopa/entacapone versus levodopa/benserazide plus pramipexole in Chinese patients with Parkinson’s disease experiencing wearing offWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-11-19Full publication date if available
- Authors
-
Weiguo Liu, Min Ye, Yang Zhao, Xueling Zhang, Xianwen Chen, Lihua Shen, Dan LiList of authors in order
- Landing page
-
https://doi.org/10.3389/fneur.2025.1682614Publisher landing page
- PDF URL
-
https://public-pages-files-2025.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1682614/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://public-pages-files-2025.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1682614/pdfDirect OA link when available
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
42Number of works referenced by this work
Full payload
| id | https://openalex.org/W4416404650 |
|---|---|
| doi | https://doi.org/10.3389/fneur.2025.1682614 |
| ids.doi | https://doi.org/10.3389/fneur.2025.1682614 |
| ids.openalex | https://openalex.org/W4416404650 |
| fwci | |
| type | article |
| title | Levodopa/carbidopa/entacapone versus levodopa/benserazide plus pramipexole in Chinese patients with Parkinson’s disease experiencing wearing off |
| biblio.issue | |
| biblio.volume | 16 |
| biblio.last_page | |
| biblio.first_page | |
| is_xpac | False |
| apc_list.value | 2950 |
| apc_list.currency | USD |
| apc_list.value_usd | 2950 |
| apc_paid.value | 2950 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 2950 |
| language | en |
| locations[0].id | doi:10.3389/fneur.2025.1682614 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S96975567 |
| locations[0].source.issn | 1664-2295 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1664-2295 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Frontiers in Neurology |
| locations[0].source.host_organization | https://openalex.org/P4310320527 |
| locations[0].source.host_organization_name | Frontiers Media |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320527 |
| locations[0].source.host_organization_lineage_names | Frontiers Media |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://public-pages-files-2025.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1682614/pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Frontiers in Neurology |
| locations[0].landing_page_url | https://doi.org/10.3389/fneur.2025.1682614 |
| locations[1].id | pmh:oai:doaj.org/article:776bd6675d244bfd8aee7f9e744b79c4 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306401280 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[1].source.host_organization | |
| locations[1].source.host_organization_name | |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | submittedVersion |
| locations[1].raw_type | article |
| locations[1].license_id | |
| locations[1].is_accepted | False |
| locations[1].is_published | False |
| locations[1].raw_source_name | Frontiers in Neurology, Vol 16 (2025) |
| locations[1].landing_page_url | https://doaj.org/article/776bd6675d244bfd8aee7f9e744b79c4 |
| indexed_in | crossref, doaj |
| authorships[0].author.id | https://openalex.org/A5100620770 |
| authorships[0].author.orcid | https://orcid.org/0000-0001-5916-9837 |
| authorships[0].author.display_name | Weiguo Liu |
| authorships[0].countries | CN |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I4210109791, https://openalex.org/I83519826 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu, China |
| authorships[0].institutions[0].id | https://openalex.org/I4210109791 |
| authorships[0].institutions[0].ror | https://ror.org/01wcx2305 |
| authorships[0].institutions[0].type | healthcare |
| authorships[0].institutions[0].lineage | https://openalex.org/I4210109791 |
| authorships[0].institutions[0].country_code | CN |
| authorships[0].institutions[0].display_name | Nanjing Brain Hospital |
| authorships[0].institutions[1].id | https://openalex.org/I83519826 |
| authorships[0].institutions[1].ror | https://ror.org/059gcgy73 |
| authorships[0].institutions[1].type | education |
| authorships[0].institutions[1].lineage | https://openalex.org/I83519826 |
| authorships[0].institutions[1].country_code | CN |
| authorships[0].institutions[1].display_name | Nanjing Medical University |
| authorships[0].author_position | middle |
| authorships[0].raw_author_name | Weiguo Liu |
| authorships[0].is_corresponding | True |
| authorships[0].raw_affiliation_strings | Department of Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu, China |
| authorships[1].author.id | https://openalex.org/A5100725242 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-9952-2380 |
| authorships[1].author.display_name | Min Ye |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Neurology, BENQ Medical Center, Nanjing, Jiangsu, China |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Min Ye |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Neurology, BENQ Medical Center, Nanjing, Jiangsu, China |
| authorships[2].author.id | https://openalex.org/A5113750225 |
| authorships[2].author.orcid | https://orcid.org/0009-0004-6687-8745 |
| authorships[2].author.display_name | Yang Zhao |
| authorships[2].countries | CN |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I131434179 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Neurology, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China |
| authorships[2].institutions[0].id | https://openalex.org/I131434179 |
| authorships[2].institutions[0].ror | https://ror.org/04523zj19 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I131434179 |
| authorships[2].institutions[0].country_code | CN |
| authorships[2].institutions[0].display_name | Nanjing University of Chinese Medicine |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Yang Zhao |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Neurology, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China |
| authorships[3].author.id | https://openalex.org/A5101924652 |
| authorships[3].author.orcid | https://orcid.org/0009-0000-6957-1205 |
| authorships[3].author.display_name | Xueling Zhang |
| authorships[3].countries | CN |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I177388780 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Neurology, The Affiliated Suqian Hospital of Xuzhou Medical University, Suqian, Jiangsu, China |
| authorships[3].institutions[0].id | https://openalex.org/I177388780 |
| authorships[3].institutions[0].ror | https://ror.org/04fe7hy80 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I177388780 |
| authorships[3].institutions[0].country_code | CN |
| authorships[3].institutions[0].display_name | Xuzhou Medical College |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Xueling Zhang |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Neurology, The Affiliated Suqian Hospital of Xuzhou Medical University, Suqian, Jiangsu, China |
| authorships[4].author.id | https://openalex.org/A5029790685 |
| authorships[4].author.orcid | https://orcid.org/0000-0001-9262-2568 |
| authorships[4].author.display_name | Xianwen Chen |
| authorships[4].countries | CN |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I197869895, https://openalex.org/I4210136596 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China |
| authorships[4].institutions[0].id | https://openalex.org/I197869895 |
| authorships[4].institutions[0].ror | https://ror.org/03xb04968 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I197869895 |
| authorships[4].institutions[0].country_code | CN |
| authorships[4].institutions[0].display_name | Anhui Medical University |
| authorships[4].institutions[1].id | https://openalex.org/I4210136596 |
| authorships[4].institutions[1].ror | https://ror.org/03t1yn780 |
| authorships[4].institutions[1].type | healthcare |
| authorships[4].institutions[1].lineage | https://openalex.org/I4210136596 |
| authorships[4].institutions[1].country_code | CN |
| authorships[4].institutions[1].display_name | First Affiliated Hospital of Anhui Medical University |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Xianwen Chen |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China |
| authorships[5].author.id | https://openalex.org/A5060845302 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-4692-6488 |
| authorships[5].author.display_name | Lihua Shen |
| authorships[5].countries | CN |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I199305430, https://openalex.org/I4210086801 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Neurology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China |
| authorships[5].institutions[0].id | https://openalex.org/I4210086801 |
| authorships[5].institutions[0].ror | https://ror.org/001rahr89 |
| authorships[5].institutions[0].type | healthcare |
| authorships[5].institutions[0].lineage | https://openalex.org/I4210086801 |
| authorships[5].institutions[0].country_code | CN |
| authorships[5].institutions[0].display_name | Affiliated Hospital of Nantong University |
| authorships[5].institutions[1].id | https://openalex.org/I199305430 |
| authorships[5].institutions[1].ror | https://ror.org/02afcvw97 |
| authorships[5].institutions[1].type | education |
| authorships[5].institutions[1].lineage | https://openalex.org/I199305430 |
| authorships[5].institutions[1].country_code | CN |
| authorships[5].institutions[1].display_name | Nantong University |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Lihua Shen |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Neurology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China |
| authorships[6].author.id | https://openalex.org/A5100380702 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-1609-1539 |
| authorships[6].author.display_name | Dan Li |
| authorships[6].countries | CN |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I4210152119 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Neurology, Jiangsu Province (Suqian) Hospital, Suqian, Jiangsu, China |
| authorships[6].institutions[0].id | https://openalex.org/I4210152119 |
| authorships[6].institutions[0].ror | https://ror.org/04py1g812 |
| authorships[6].institutions[0].type | healthcare |
| authorships[6].institutions[0].lineage | https://openalex.org/I4210152119 |
| authorships[6].institutions[0].country_code | CN |
| authorships[6].institutions[0].display_name | Jiangsu Province Hospital |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Dan Li |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Neurology, Jiangsu Province (Suqian) Hospital, Suqian, Jiangsu, China |
| has_content.pdf | True |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://public-pages-files-2025.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1682614/pdf |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-11-19T00:00:00 |
| display_name | Levodopa/carbidopa/entacapone versus levodopa/benserazide plus pramipexole in Chinese patients with Parkinson’s disease experiencing wearing off |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-28T13:13:30.226576 |
| primary_topic | |
| cited_by_count | 0 |
| locations_count | 2 |
| best_oa_location.id | doi:10.3389/fneur.2025.1682614 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S96975567 |
| best_oa_location.source.issn | 1664-2295 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1664-2295 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Frontiers in Neurology |
| best_oa_location.source.host_organization | https://openalex.org/P4310320527 |
| best_oa_location.source.host_organization_name | Frontiers Media |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320527 |
| best_oa_location.source.host_organization_lineage_names | Frontiers Media |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://public-pages-files-2025.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1682614/pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Frontiers in Neurology |
| best_oa_location.landing_page_url | https://doi.org/10.3389/fneur.2025.1682614 |
| primary_location.id | doi:10.3389/fneur.2025.1682614 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S96975567 |
| primary_location.source.issn | 1664-2295 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1664-2295 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Frontiers in Neurology |
| primary_location.source.host_organization | https://openalex.org/P4310320527 |
| primary_location.source.host_organization_name | Frontiers Media |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320527 |
| primary_location.source.host_organization_lineage_names | Frontiers Media |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://public-pages-files-2025.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1682614/pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Frontiers in Neurology |
| primary_location.landing_page_url | https://doi.org/10.3389/fneur.2025.1682614 |
| publication_date | 2025-11-19 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W2168605004, https://openalex.org/W2797543943, https://openalex.org/W2923726522, https://openalex.org/W2156991891, https://openalex.org/W3152331063, https://openalex.org/W2965325483, https://openalex.org/W1996788108, https://openalex.org/W2075034668, https://openalex.org/W4385294175, https://openalex.org/W2170999819, https://openalex.org/W2119257560, https://openalex.org/W1984593979, https://openalex.org/W2007202520, https://openalex.org/W2071010820, https://openalex.org/W2051723119, https://openalex.org/W1988948351, https://openalex.org/W2562079640, https://openalex.org/W2112455323, https://openalex.org/W2032885828, https://openalex.org/W1985814672, https://openalex.org/W3134337211, https://openalex.org/W2019345577, https://openalex.org/W2141713617, https://openalex.org/W2726672065, https://openalex.org/W2089085990, https://openalex.org/W4211223857, https://openalex.org/W2128364757, https://openalex.org/W2087558873, https://openalex.org/W2142359920, https://openalex.org/W2158005416, https://openalex.org/W4293036915, https://openalex.org/W3084064217, https://openalex.org/W2152837663, https://openalex.org/W2114136397, https://openalex.org/W2543601459, https://openalex.org/W2106350754, https://openalex.org/W2041571178, https://openalex.org/W2007297814, https://openalex.org/W1973698406, https://openalex.org/W2090011009, https://openalex.org/W1997346120, https://openalex.org/W4408296642 |
| referenced_works_count | 42 |
| abstract_inverted_index.( | 154, 197 |
| abstract_inverted_index.+ | 65, 259 |
| abstract_inverted_index.2 | 246 |
| abstract_inverted_index.7 | 223 |
| abstract_inverted_index.8 | 70, 128 |
| abstract_inverted_index.= | 156, 199 |
| abstract_inverted_index.p | 134, 141, 155, 177, 184, 198 |
| abstract_inverted_index.49 | 107 |
| abstract_inverted_index.In | 33 |
| abstract_inverted_index.LB | 17, 52, 64, 258 |
| abstract_inverted_index.ON | 171 |
| abstract_inverted_index.PD | 44, 271 |
| abstract_inverted_index.To | 1 |
| abstract_inverted_index.WO | 46, 206 |
| abstract_inverted_index.h, | 133, 176 |
| abstract_inverted_index.in | 21, 77, 85, 102, 109, 218, 226, 241, 248, 267 |
| abstract_inverted_index.of | 7, 213, 233 |
| abstract_inverted_index.on | 50 |
| abstract_inverted_index.or | 63 |
| abstract_inverted_index.to | 13, 59 |
| abstract_inverted_index.± | 131, 139, 174, 182 |
| abstract_inverted_index.140 | 41 |
| abstract_inverted_index.3:2 | 58 |
| abstract_inverted_index.LCE | 61, 104, 117, 161, 220, 243, 256 |
| abstract_inverted_index.OFF | 124 |
| abstract_inverted_index.One | 239 |
| abstract_inverted_index.PPX | 66, 111, 119, 165, 228, 250, 260 |
| abstract_inverted_index.Six | 215 |
| abstract_inverted_index.The | 72 |
| abstract_inverted_index.WO. | 274 |
| abstract_inverted_index.all | 232 |
| abstract_inverted_index.and | 5, 56, 106, 118, 137, 145, 163, 180, 188, 211, 222, 237, 245, 257, 265 |
| abstract_inverted_index.for | 69 |
| abstract_inverted_index.had | 48, 167 |
| abstract_inverted_index.off | 30 |
| abstract_inverted_index.the | 3, 78, 86, 103, 110, 114, 121, 146, 151, 160, 164, 189, 194, 204, 219, 227, 242, 249 |
| abstract_inverted_index.two | 152, 195 |
| abstract_inverted_index.was | 75, 90 |
| abstract_inverted_index.who | 47, 272 |
| abstract_inverted_index.(56) | 67 |
| abstract_inverted_index.(84) | 62 |
| abstract_inverted_index.(LB) | 12 |
| abstract_inverted_index.(PD) | 27 |
| abstract_inverted_index.1.38 | 181 |
| abstract_inverted_index.1.59 | 175 |
| abstract_inverted_index.1.70 | 132 |
| abstract_inverted_index.Both | 116, 201 |
| abstract_inverted_index.also | 91 |
| abstract_inverted_index.been | 49 |
| abstract_inverted_index.both | 159, 262 |
| abstract_inverted_index.from | 10, 82 |
| abstract_inverted_index.mild | 236, 253 |
| abstract_inverted_index.plus | 18 |
| abstract_inverted_index.safe | 264 |
| abstract_inverted_index.this | 34 |
| abstract_inverted_index.time | 81, 89, 125, 172 |
| abstract_inverted_index.were | 54, 97, 148, 191, 235, 261 |
| abstract_inverted_index.with | 24, 43, 270 |
| abstract_inverted_index.(1.62 | 173 |
| abstract_inverted_index.(LCE) | 15 |
| abstract_inverted_index.(PPX) | 20 |
| abstract_inverted_index.(WO). | 31 |
| abstract_inverted_index.0.001 | 136, 179 |
| abstract_inverted_index.1.60, | 140 |
| abstract_inverted_index.1.65, | 183 |
| abstract_inverted_index.after | 127 |
| abstract_inverted_index.daily | 79, 87, 123, 170 |
| abstract_inverted_index.group | 105, 112, 162, 166, 221, 229, 244, 251 |
| abstract_inverted_index.life. | 214 |
| abstract_inverted_index.sleep | 208 |
| abstract_inverted_index.weeks | 129 |
| abstract_inverted_index.which | 234 |
| abstract_inverted_index.0.001, | 143, 186 |
| abstract_inverted_index.Change | 84 |
| abstract_inverted_index.TEAEs, | 231 |
| abstract_inverted_index.change | 76 |
| abstract_inverted_index.direct | 8 |
| abstract_inverted_index.events | 95 |
| abstract_inverted_index.groups | 153, 196 |
| abstract_inverted_index.safety | 6 |
| abstract_inverted_index.stable | 51 |
| abstract_inverted_index.study, | 40 |
| abstract_inverted_index.study. | 115 |
| abstract_inverted_index.switch | 9 |
| abstract_inverted_index.versus | 16 |
| abstract_inverted_index.weeks. | 71 |
| abstract_inverted_index.(7.59%) | 216 |
| abstract_inverted_index.(TEAEs) | 96 |
| abstract_inverted_index.0.412). | 200 |
| abstract_inverted_index.0.414). | 157 |
| abstract_inverted_index.Chinese | 22 |
| abstract_inverted_index.Methods | 32 |
| abstract_inverted_index.Results | 99 |
| abstract_inverted_index.adverse | 94 |
| abstract_inverted_index.between | 150, 193 |
| abstract_inverted_index.compare | 2 |
| abstract_inverted_index.disease | 26 |
| abstract_inverted_index.patient | 240 |
| abstract_inverted_index.primary | 73 |
| abstract_inverted_index.quality | 212 |
| abstract_inverted_index.receive | 60 |
| abstract_inverted_index.wearing | 29 |
| abstract_inverted_index.−1.51 | 138 |
| abstract_inverted_index.&lt; | 135, 142, 178, 185 |
| abstract_inverted_index.(14.29%) | 224 |
| abstract_inverted_index.(−1.76 | 130 |
| abstract_inverted_index.efficacy | 4 |
| abstract_inverted_index.endpoint | 74 |
| abstract_inverted_index.enrolled | 55 |
| abstract_inverted_index.improved | 203 |
| abstract_inverted_index.patients | 23, 42, 101, 108, 217, 225, 247, 269 |
| abstract_inverted_index.quality, | 209 |
| abstract_inverted_index.reported | 230 |
| abstract_inverted_index.treating | 268 |
| abstract_inverted_index.“ON” | 88 |
| abstract_inverted_index.Objective | 0 |
| abstract_inverted_index.assessed. | 92 |
| abstract_inverted_index.baseline. | 83 |
| abstract_inverted_index.completed | 113 |
| abstract_inverted_index.increased | 169 |
| abstract_inverted_index.increases | 190 |
| abstract_inverted_index.recorded. | 98 |
| abstract_inverted_index.shortened | 120 |
| abstract_inverted_index.symptoms, | 207 |
| abstract_inverted_index.tolerable | 266 |
| abstract_inverted_index.treatment | 53, 68 |
| abstract_inverted_index.“OFF” | 80 |
| abstract_inverted_index.Conclusion | 255 |
| abstract_inverted_index.comparable | 149, 192 |
| abstract_inverted_index.depression | 210 |
| abstract_inverted_index.effective, | 263 |
| abstract_inverted_index.randomized | 57 |
| abstract_inverted_index.tolerable. | 238 |
| abstract_inverted_index.treatments | 202 |
| abstract_inverted_index.dyskinesia. | 254 |
| abstract_inverted_index.experienced | 252, 273 |
| abstract_inverted_index.open-label, | 38 |
| abstract_inverted_index.patients’ | 122, 205 |
| abstract_inverted_index.pramipexole | 19 |
| abstract_inverted_index.randomized, | 37 |
| abstract_inverted_index.shortenings | 147 |
| abstract_inverted_index.Seventy-nine | 100 |
| abstract_inverted_index.experiencing | 28, 45 |
| abstract_inverted_index.multicenter, | 35 |
| abstract_inverted_index.prospective, | 36 |
| abstract_inverted_index.Parkinson’s | 25 |
| abstract_inverted_index.observational | 39 |
| abstract_inverted_index.significantly | 126, 168 |
| abstract_inverted_index.respectively), | 144, 187 |
| abstract_inverted_index.Correspondingly, | 158 |
| abstract_inverted_index.Treatment-emergent | 93 |
| abstract_inverted_index.levodopa/benserazide | 11 |
| abstract_inverted_index.levodopa/carbidopa/entacapone | 14 |
| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5100620770 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 7 |
| corresponding_institution_ids | https://openalex.org/I4210109791, https://openalex.org/I83519826 |
| citation_normalized_percentile |