Life’s Essential 8 Article Swipe
Manish Kumar
,
Ariela R. Orkaby
,
Caitlan A. Tighe
,
Dennis T. Villareal
,
Hayley Billingsley
,
Michael G. Nanna
,
Min Ji Kwak
,
Namit Rohant
,
Shreya Patel
,
Parag Goyal
,
Scott L. Hummel
,
Christina Al-Malouf
,
Amie Kolimas
,
Ashok Krishnaswami
,
Michael W. Rich
,
James N. Kirkpatrick
,
Abdulla A. Damluji
,
George A. Kuchel
,
Daniel E. Forman
,
Karen P. Alexander
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1016/j.jacadv.2023.100560
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1016/j.jacadv.2023.100560
The population worldwide is getting older as a result of advances in public health, medicine, and technology. Older individuals are living longer with a higher prevalence of subclinical and clinical cardiovascular disease (CVD). In 2010, the American Heart Association introduced a list of key prevention targets, known as "Life's Simple 7" to increase CVD-free survival, longevity, and quality of life. In 2022, sleep health was added to expand the recommendations to "Life's Essential 8" (eat better, be more active, stop smoking, get adequate sleep, manage weight, manage cholesterol, manage blood pressure, and manage diabetes). These prevention targets are intended to apply regardless of chronologic age. During this same time, the understanding of aging biology and goals of care for older adults further enhanced the relevance of prevention across the range of functions. From a biological perspective, aging is a complex cellular process characterized by genomic instability, telomere attrition, loss of proteostasis, inflammation, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. These aging hallmarks are triggered by and enhanced by traditional CVD risk factors leading to geriatric syndromes (eg, frailty, sarcopenia, functional limitation, and cognitive impairment) which complicate efforts toward prevention. Therefore, we review Life's Essential 8 through the lens of aging biology, geroscience, and geriatric precepts to guide clinicians taking care of older adults.
Related Topics
Concepts
Gerontology
Proteostasis
Medicine
Life expectancy
Successful aging
Disease
Longevity
Quality of life (healthcare)
Sarcopenia
Geriatrics
Subclinical infection
Senescence
Healthy aging
Population
Intensive care medicine
Biology
Environmental health
Psychiatry
Pathology
Internal medicine
Nursing
Genetics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.jacadv.2023.100560
- OA Status
- diamond
- Cited By
- 27
- References
- 208
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4386088911
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4386088911Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.jacadv.2023.100560Digital Object Identifier
- Title
-
Life’s Essential 8Work title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-08-22Full publication date if available
- Authors
-
Manish Kumar, Ariela R. Orkaby, Caitlan A. Tighe, Dennis T. Villareal, Hayley Billingsley, Michael G. Nanna, Min Ji Kwak, Namit Rohant, Shreya Patel, Parag Goyal, Scott L. Hummel, Christina Al-Malouf, Amie Kolimas, Ashok Krishnaswami, Michael W. Rich, James N. Kirkpatrick, Abdulla A. Damluji, George A. Kuchel, Daniel E. Forman, Karen P. AlexanderList of authors in order
- Landing page
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https://doi.org/10.1016/j.jacadv.2023.100560Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1016/j.jacadv.2023.100560Direct OA link when available
- Concepts
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Gerontology, Proteostasis, Medicine, Life expectancy, Successful aging, Disease, Longevity, Quality of life (healthcare), Sarcopenia, Geriatrics, Subclinical infection, Senescence, Healthy aging, Population, Intensive care medicine, Biology, Environmental health, Psychiatry, Pathology, Internal medicine, Nursing, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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27Total citation count in OpenAlex
- Citations by year (recent)
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2025: 18, 2024: 9Per-year citation counts (last 5 years)
- References (count)
-
208Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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