Lifetime water arsenic, genetic susceptibility, and bladder cancer in the New England Bladder Cancer Study Article Swipe
Hugo Pomares‐Millan
,
Stella Koutros
,
Dalsu Baris
,
Molly Schwenn
,
Alison Johnson
,
Nathaniel Rothman
,
Debra T. Silverman
,
Steven D. Leach
,
Margaret R. Karagas
,
Michael N. Passarelli
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1093/jncics/pkaf064
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1093/jncics/pkaf064
Background Exposure to arsenic in drinking water may interact with common genetic variants in urinary bladder cancer risk. Methods We conducted a gene-environment interaction analysis among 1091 bladder cancer cases and 928 controls from the New England Bladder Cancer Study. Genetic variants tested as effect modifiers included those associated with bladder cancer and arsenic metabolism. Interactions with disease-specific polygenic scores and a genome-wide gene-environment interaction analysis were also conducted. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated with average arsenic concentration (µg/L), average daily arsenic (µg/day), and cumulative arsenic (mg) in water as exposures. Results Multiplicative interactions for bladder cancer risk were identified for cumulative arsenic and rs1046428 of GSTZ1 on 14q23 (TT and TC genotype: ORT3vsT1 = 1.44, 95% CI = 1.05 to 1.98; Pinteraction= .01) and for average daily arsenic and rs1801133 (C677T) and rs1801131 (A1298C) of MTHFR on 1p36 (TT and TC genotypes: ORT3vsT1 = 1.53, 95% CI = 1.06 to 2.23; Pinteraction= .02; CC and CA genotype: ORT3vsT1 = 1.63, 95% CI = 1.16 to 2.29; Pinteraction=.01, respectively). A global interaction between arsenic exposure and polygenic scores was also observed (ORT3vsT1 = 1.80, 95% CI = 1.26 to 2.56; Pinteraction=. 01). Genome-wide gene-environment interaction analyses suggested interactions with 5 loci with a Pinteraction of no more than 5e-6. Conclusions Genetic variants that function in arsenic metabolism involving folate and oxidative stress pathways and a global summary of genetic susceptibility to bladder cancer may modify the association between elevated arsenic exposure from drinking water and bladder cancer.
Related Topics
Concepts
Bladder cancer
Methylenetetrahydrofolate reductase
Odds ratio
Genotype
Gene–environment interaction
Medicine
Cancer
Confidence interval
Genetic predisposition
Internal medicine
Urinary Bladder Cancer
Oncology
Genetics
Physiology
Disease
Biology
Gene
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/jncics/pkaf064
- OA Status
- gold
- References
- 58
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4411747929
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4411747929Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1093/jncics/pkaf064Digital Object Identifier
- Title
-
Lifetime water arsenic, genetic susceptibility, and bladder cancer in the New England Bladder Cancer StudyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-06-13Full publication date if available
- Authors
-
Hugo Pomares‐Millan, Stella Koutros, Dalsu Baris, Molly Schwenn, Alison Johnson, Nathaniel Rothman, Debra T. Silverman, Steven D. Leach, Margaret R. Karagas, Michael N. PassarelliList of authors in order
- Landing page
-
https://doi.org/10.1093/jncics/pkaf064Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1093/jncics/pkaf064Direct OA link when available
- Concepts
-
Bladder cancer, Methylenetetrahydrofolate reductase, Odds ratio, Genotype, Gene–environment interaction, Medicine, Cancer, Confidence interval, Genetic predisposition, Internal medicine, Urinary Bladder Cancer, Oncology, Genetics, Physiology, Disease, Biology, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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58Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| referenced_works | https://openalex.org/W3215841463, https://openalex.org/W3145816918, https://openalex.org/W4324136637, https://openalex.org/W2032659674, https://openalex.org/W2162130153, https://openalex.org/W2113869386, https://openalex.org/W2903314150, https://openalex.org/W2014779809, https://openalex.org/W3087805467, https://openalex.org/W2225530246, https://openalex.org/W4377100807, https://openalex.org/W2901078674, https://openalex.org/W2128024417, https://openalex.org/W2138629620, https://openalex.org/W1977089938, https://openalex.org/W2011225987, https://openalex.org/W4283580126, https://openalex.org/W1833843483, https://openalex.org/W2045328256, https://openalex.org/W4229439861, https://openalex.org/W2346554829, https://openalex.org/W2171668747, https://openalex.org/W2083610541, https://openalex.org/W2849101016, https://openalex.org/W2039310245, https://openalex.org/W2510973425, https://openalex.org/W1878939331, https://openalex.org/W2161633633, https://openalex.org/W2037698809, https://openalex.org/W1964031786, https://openalex.org/W4317600689, https://openalex.org/W3088258981, https://openalex.org/W4391886183, https://openalex.org/W4206175800, https://openalex.org/W2157344190, https://openalex.org/W3134184401, https://openalex.org/W3204186164, https://openalex.org/W1565224655, https://openalex.org/W2144547147, https://openalex.org/W2057893631, https://openalex.org/W1986674623, https://openalex.org/W1986017285, https://openalex.org/W2043993008, https://openalex.org/W4214510316, https://openalex.org/W3160414859, https://openalex.org/W1970291988, https://openalex.org/W2159134046, https://openalex.org/W6676849525, https://openalex.org/W2066950703, https://openalex.org/W2006938519, https://openalex.org/W2570195768, https://openalex.org/W2085989394, https://openalex.org/W4323920717, https://openalex.org/W4388018115, https://openalex.org/W3005130511, https://openalex.org/W1981443314, https://openalex.org/W2149906826, https://openalex.org/W1979358400 |
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| abstract_inverted_index.95% | 74, 122, 152, 167, 190 |
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| abstract_inverted_index.1.53, | 151 |
| abstract_inverted_index.1.63, | 166 |
| abstract_inverted_index.1.80, | 189 |
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| abstract_inverted_index.2.23; | 157 |
| abstract_inverted_index.2.29; | 172 |
| abstract_inverted_index.2.56; | 195 |
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