Ligand-based Exosome Affinity Purification (LEAP) Column Chromatography: A Tool for Clinical Applications Article Swipe
Nadiar M. Mussin
,
Akmaral Baspakova
,
Kulyash R. Zhilisbayeva
,
Seyyed Mojtaba Mousavi
,
Reza Shirazi
,
Aigerim A. Umbetova
,
Amin Tamadon
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.18502/wkmj.v66i4.17768
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.18502/wkmj.v66i4.17768
Exosomes are nano-sized extracellular vesicles that play essential roles in intercellular communication, carrying biomolecules such as proteins, lipids, and RNAs that can influence physiological and pathological processes. The isolation of pure exosomes is critical for both basic research and clinical applications, including diagnostics and therapeutics. Traditional exosome isolation techniques, such as ultracentrifugation, lack specificity and may yield impure samples, making the need for advanced isolation techniques evident. Ligand-based exosome affinity purification (LEAP) column chromatography has emerged as a novel method that utilizes specific ligands targeting exosome surface markers, providing a highly specific, gentle, and scalable approach to exosome isolation. This mini review explores LEAP chromatography’s mechanism, benefits, and potential for clinical applications, emphasizing its g.rowing importance in exosome-based diagnostics and therapies.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.18502/wkmj.v66i4.17768
- OA Status
- diamond
- Cited By
- 1
- References
- 26
- Related Works
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- OpenAlex ID
- https://openalex.org/W4405643263
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4405643263Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.18502/wkmj.v66i4.17768Digital Object Identifier
- Title
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Ligand-based Exosome Affinity Purification (LEAP) Column Chromatography: A Tool for Clinical ApplicationsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-12-20Full publication date if available
- Authors
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Nadiar M. Mussin, Akmaral Baspakova, Kulyash R. Zhilisbayeva, Seyyed Mojtaba Mousavi, Reza Shirazi, Aigerim A. Umbetova, Amin TamadonList of authors in order
- Landing page
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https://doi.org/10.18502/wkmj.v66i4.17768Publisher landing page
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YesWhether a free full text is available
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diamondOpen access status per OpenAlex
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https://doi.org/10.18502/wkmj.v66i4.17768Direct OA link when available
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Affinity chromatography, Column (typography), Chromatography, Exosome, Ligand (biochemistry), Chemistry, Computational biology, Computer science, Microvesicles, Biology, Biochemistry, Receptor, Gene, microRNA, Telecommunications, Frame (networking), EnzymeTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1Per-year citation counts (last 5 years)
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26Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.surface | 86 |
| abstract_inverted_index.Exosomes | 0 |
| abstract_inverted_index.advanced | 63 |
| abstract_inverted_index.affinity | 69 |
| abstract_inverted_index.approach | 95 |
| abstract_inverted_index.carrying | 12 |
| abstract_inverted_index.clinical | 39, 110 |
| abstract_inverted_index.critical | 33 |
| abstract_inverted_index.evident. | 66 |
| abstract_inverted_index.exosomes | 31 |
| abstract_inverted_index.explores | 102 |
| abstract_inverted_index.g.rowing | 114 |
| abstract_inverted_index.markers, | 87 |
| abstract_inverted_index.research | 37 |
| abstract_inverted_index.samples, | 58 |
| abstract_inverted_index.scalable | 94 |
| abstract_inverted_index.specific | 82 |
| abstract_inverted_index.utilizes | 81 |
| abstract_inverted_index.vesicles | 4 |
| abstract_inverted_index.benefits, | 106 |
| abstract_inverted_index.essential | 7 |
| abstract_inverted_index.including | 41 |
| abstract_inverted_index.influence | 22 |
| abstract_inverted_index.isolation | 28, 47, 64 |
| abstract_inverted_index.potential | 108 |
| abstract_inverted_index.proteins, | 16 |
| abstract_inverted_index.providing | 88 |
| abstract_inverted_index.specific, | 91 |
| abstract_inverted_index.targeting | 84 |
| abstract_inverted_index.importance | 115 |
| abstract_inverted_index.isolation. | 98 |
| abstract_inverted_index.mechanism, | 105 |
| abstract_inverted_index.nano-sized | 2 |
| abstract_inverted_index.processes. | 26 |
| abstract_inverted_index.techniques | 65 |
| abstract_inverted_index.therapies. | 120 |
| abstract_inverted_index.Traditional | 45 |
| abstract_inverted_index.diagnostics | 42, 118 |
| abstract_inverted_index.emphasizing | 112 |
| abstract_inverted_index.specificity | 53 |
| abstract_inverted_index.techniques, | 48 |
| abstract_inverted_index.Ligand-based | 67 |
| abstract_inverted_index.biomolecules | 13 |
| abstract_inverted_index.pathological | 25 |
| abstract_inverted_index.purification | 70 |
| abstract_inverted_index.applications, | 40, 111 |
| abstract_inverted_index.exosome-based | 117 |
| abstract_inverted_index.extracellular | 3 |
| abstract_inverted_index.intercellular | 10 |
| abstract_inverted_index.physiological | 23 |
| abstract_inverted_index.therapeutics. | 44 |
| abstract_inverted_index.chromatography | 73 |
| abstract_inverted_index.communication, | 11 |
| abstract_inverted_index.chromatography’s | 104 |
| abstract_inverted_index.ultracentrifugation, | 51 |
| cited_by_percentile_year.max | 95 |
| cited_by_percentile_year.min | 91 |
| countries_distinct_count | 0 |
| institutions_distinct_count | 7 |
| citation_normalized_percentile.value | 0.64169009 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |