Lights on MsFLASH: a review of contributions Article Swipe
Susan D. Reed
,
Andrea Z. LaCroix
,
Garnet L. Anderson
,
Kristine E. Ensrud
,
Bette J. Caan
,
Janet S. Carpenter
,
Lee S. Cohen
,
Susan J. Diem
,
Ellen W. Freeman
,
Hadine Joffe
,
Joseph C. Larson
,
Susan M. McCurry
,
Caroline M. Mitchell
,
Katherine M. Newton
,
Barbara Sternfeld
,
Katherine A. Guthrie
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1097/gme.0000000000001461
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1097/gme.0000000000001461
Objective: The Menopause Strategies: Finding Lasting Answers for Symptoms and Health clinical trials network was funded by the National Institutes of Health to find new ways to alleviate the most common, bothersome menopausal symptoms by designing and conducting multiple concurrent clinical intervention studies, accommodating a wide scope of populations and intervention strategies. Methods: Trials were conducted in Boston, Indianapolis, Minneapolis, Oakland, Philadelphia, and Seattle, with the Data Coordinating Center in Seattle, and were designed with standardized eligibility criteria and endpoints. Primary outcomes focused on vasomotor symptoms, sleep quality and insomnia symptoms, and vaginal symptoms. Secondary outcomes included quality of life, sexual function, and mood. Results: We completed five randomized clinical trials and three ancillary studies, testing nine interventions in over 1,300 women and collecting nearly 16,000 bio-specimens. Escitalopram, venlafaxine hydrochloride extended release, and low-dose estradiol diminished hot flashes by approximately 50% as compared with a 30% decrease by placebo. No benefits on vasomotor symptoms were observed with yoga or exercise compared with usual activity, nor with omega-3 supplementation compared with placebo. Cognitive behavioral therapy for insomnia reduced self-reported insomnia symptoms and improved overall sleep quality compared with menopause education control. We did not find significant benefit from a vaginal estradiol tablet or a vaginal moisturizer compared with placebo tablet and gel in diminishing the severity of vaginal symptoms. Conclusions: The MsFLASH trials contributed substantially to our understanding of bothersome menopausal symptom treatment. It is important that clinicians counseling women about available treatment options consider all therapies—both nonhormonal and hormonal.
Related Topics
Concepts
Medicine
Mood
Randomized controlled trial
Placebo
Quality of life (healthcare)
Menopause
Clinical trial
Cognitive behavioral therapy for insomnia
Physical therapy
Psychological intervention
Escitalopram
Anxiety
Internal medicine
Cognitive behavioral therapy
Psychiatry
Alternative medicine
Nursing
Pathology
Antidepressant
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1097/gme.0000000000001461
- OA Status
- green
- Cited By
- 21
- References
- 64
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3001136035
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3001136035Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1097/gme.0000000000001461Digital Object Identifier
- Title
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Lights on MsFLASH: a review of contributionsWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
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2020-01-24Full publication date if available
- Authors
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Susan D. Reed, Andrea Z. LaCroix, Garnet L. Anderson, Kristine E. Ensrud, Bette J. Caan, Janet S. Carpenter, Lee S. Cohen, Susan J. Diem, Ellen W. Freeman, Hadine Joffe, Joseph C. Larson, Susan M. McCurry, Caroline M. Mitchell, Katherine M. Newton, Barbara Sternfeld, Katherine A. GuthrieList of authors in order
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://www.ncbi.nlm.nih.gov/pmc/articles/8009305Direct OA link when available
- Concepts
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Medicine, Mood, Randomized controlled trial, Placebo, Quality of life (healthcare), Menopause, Clinical trial, Cognitive behavioral therapy for insomnia, Physical therapy, Psychological intervention, Escitalopram, Anxiety, Internal medicine, Cognitive behavioral therapy, Psychiatry, Alternative medicine, Nursing, Pathology, AntidepressantTop concepts (fields/topics) attached by OpenAlex
- Cited by
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21Total citation count in OpenAlex
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2025: 4, 2024: 2, 2023: 6, 2022: 2, 2021: 2Per-year citation counts (last 5 years)
- References (count)
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64Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| corresponding_author_ids | https://openalex.org/A5049708025 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 16 |
| corresponding_institution_ids | https://openalex.org/I201448701 |
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