Limbic network co‐localization predicts pharmacoresistance in dysplasia‐related epilepsy Article Swipe
Nathan T. Cohen
,
Phat Chang
,
Taha Gholipour
,
Chima Oluigbo
,
L. Gilbert Vezina
,
Hua Xie
,
Anqing Zhang
,
William D. Gaillard
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1002/acn3.51892
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1002/acn3.51892
To evaluate the role of focal cortical dysplasia co‐localization to cortical functional networks in the development of pharmacoresistance. One hundred thirty‐six focal cortical dysplasia patients with 3.0 T or 1.5 T MRI were identified from clinical databases at Children's National Hospital. Clinico‐radio‐pathologic factors and network co‐localization were determined. Using binomial logistic regression, limbic network co‐localization (odds ratio 4.164 95% confidence interval 1.02–17.08, p = 0.048), and focal to bilateral tonic–clonic seizures (4.82, 1.30–18.03, p = 0.019) predicted pharmacoresistance. These findings provide clinicians with markers to identify patients with focal cortical dysplasia‐related epilepsy at high risk of developing pharmacoresistance and should facilitate earlier epilepsy surgical evaluation.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/acn3.51892
- OA Status
- gold
- Cited By
- 6
- References
- 19
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4386704677
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4386704677Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/acn3.51892Digital Object Identifier
- Title
-
Limbic network co‐localization predicts pharmacoresistance in dysplasia‐related epilepsyWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-09-12Full publication date if available
- Authors
-
Nathan T. Cohen, Phat Chang, Taha Gholipour, Chima Oluigbo, L. Gilbert Vezina, Hua Xie, Anqing Zhang, William D. GaillardList of authors in order
- Landing page
-
https://doi.org/10.1002/acn3.51892Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1002/acn3.51892Direct OA link when available
- Concepts
-
Medicine, Cortical dysplasia, Odds ratio, Confidence interval, Epilepsy, Dysplasia, Pathology, Internal medicine, PsychiatryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
6Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3, 2024: 3Per-year citation counts (last 5 years)
- References (count)
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19Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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