Limited cutaneous systemic sclerosis skin demonstrates distinct molecular subsets separated by a cardiovascular development gene expression signature Article Swipe

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Rheumatology Signature (topology) Gene expression Medicine Gene Internal medicine Gene signature Bioinformatics Pathology Immunology Biology Genetics Mathematics Geometry

Emma Derrett‐Smith , Viktor Martyanov , Cecilia Beatrice Chighizola , Pia Moinzadeh , Corrado Campochiaro , Korsa Khan , Tammara Wood , Pier Luigi Meroni , David Abraham , Voon H Ong , Robert Lafyatis , Michael L. Whitfield , Christopher P. Denton ·

YOU? · · 2017 · Open Access · · DOI: https://doi.org/10.1186/s13075-017-1360-7 · OA: W2732354775

Our study suggests the presence of molecular subsets in lcSSc based on gene expression profiling of biopsies from uninvolved skin. This may reflect important differences in pathogenesis within these patient groups. We identify differential expression of a subset of genes that relate to CVS and are enriched in fibrotic signalling. This may shed light on mechanisms of vascular disease in SSc. The enrichment in profibrotic profile suggests that dysregulated gene expression may contribute to vasculopathy and fibrosis in different disease subsets.