Lineage tracing of human embryonic development and foetal haematopoiesis through somatic mutations Article Swipe
Michael Spencer Chapman
,
Anna Maria Ranzoni
,
Brynelle Myers
,
Nick Williams
,
Tim H. H. Coorens
,
Emily Mitchell
,
Timothy Butler
,
Kevin J. Dawson
,
Yvette Hooks
,
Luiza Moore
,
Jyoti Nangalia
,
Philip S. Robinson
,
Elizabeth Hook
,
Peter J. Campbell
,
Ana Cvejic
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1101/2020.05.29.088765
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1101/2020.05.29.088765
To date, ontogeny of the human haematopoietic system during foetal development has been characterized mainly through careful microscopic observations. Here we used whole-genome sequencing (WGS) of 511 single-cell derived haematopoietic colonies from healthy human foetuses of 8 and 18 post-conception weeks (pcw) coupled with deep targeted sequencing of tissues of known embryonic origin to reconstruct a phylogenetic tree of blood development. We found that in healthy foetuses, individual haematopoietic progenitors acquire tens of somatic mutations by 18 pcw. Using these mutations as barcodes, we timed the divergence of embryonic and extra-embryonic tissues during development and estimated the number of blood antecedents at different stages of embryonic development. Our analysis has shown that ectoderm originates from a smaller set of blood antecedents compared to endoderm and mesoderm. Finally, our data support a hypoblast origin of the extra-embryonic mesoderm and primitive blood in humans.
Related Topics
Concepts
Biology
Mesoderm
Endoderm
Embryogenesis
Embryonic stem cell
Somatic cell
Haematopoiesis
Ectoderm
Genetics
Cell biology
Embryo
Stem cell
Gene
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2020.05.29.088765
- https://www.biorxiv.org/content/biorxiv/early/2020/05/30/2020.05.29.088765.full.pdf
- OA Status
- green
- Cited By
- 6
- References
- 32
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3029234486
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3029234486Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1101/2020.05.29.088765Digital Object Identifier
- Title
-
Lineage tracing of human embryonic development and foetal haematopoiesis through somatic mutationsWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-05-30Full publication date if available
- Authors
-
Michael Spencer Chapman, Anna Maria Ranzoni, Brynelle Myers, Nick Williams, Tim H. H. Coorens, Emily Mitchell, Timothy Butler, Kevin J. Dawson, Yvette Hooks, Luiza Moore, Jyoti Nangalia, Philip S. Robinson, Elizabeth Hook, Peter J. Campbell, Ana CvejicList of authors in order
- Landing page
-
https://doi.org/10.1101/2020.05.29.088765Publisher landing page
- PDF URL
-
https://www.biorxiv.org/content/biorxiv/early/2020/05/30/2020.05.29.088765.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.biorxiv.org/content/biorxiv/early/2020/05/30/2020.05.29.088765.full.pdfDirect OA link when available
- Concepts
-
Biology, Mesoderm, Endoderm, Embryogenesis, Embryonic stem cell, Somatic cell, Haematopoiesis, Ectoderm, Genetics, Cell biology, Embryo, Stem cell, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
6Total citation count in OpenAlex
- Citations by year (recent)
-
2021: 2, 2020: 4Per-year citation counts (last 5 years)
- References (count)
-
32Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W3029234486 |
|---|---|
| doi | https://doi.org/10.1101/2020.05.29.088765 |
| ids.doi | https://doi.org/10.1101/2020.05.29.088765 |
| ids.mag | 3029234486 |
| ids.openalex | https://openalex.org/W3029234486 |
| fwci | 0.58516184 |
| type | preprint |
| title | Lineage tracing of human embryonic development and foetal haematopoiesis through somatic mutations |
| biblio.issue | |
| biblio.volume | |
| biblio.last_page | |
| biblio.first_page | |
| topics[0].id | https://openalex.org/T11289 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9994000196456909 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1312 |
| topics[0].subfield.display_name | Molecular Biology |
| topics[0].display_name | Single-cell and spatial transcriptomics |
| topics[1].id | https://openalex.org/T11685 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9950000047683716 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1307 |
| topics[1].subfield.display_name | Cell Biology |
| topics[1].display_name | Zebrafish Biomedical Research Applications |
| topics[2].id | https://openalex.org/T11287 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.9944000244140625 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1306 |
| topics[2].subfield.display_name | Cancer Research |
| topics[2].display_name | Cancer Genomics and Diagnostics |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C86803240 |
| concepts[0].level | 0 |
| concepts[0].score | 0.8076901435852051 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[0].display_name | Biology |
| concepts[1].id | https://openalex.org/C2780915607 |
| concepts[1].level | 4 |
| concepts[1].score | 0.7604467272758484 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q323438 |
| concepts[1].display_name | Mesoderm |
| concepts[2].id | https://openalex.org/C2777164004 |
| concepts[2].level | 4 |
| concepts[2].score | 0.6339001655578613 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q331858 |
| concepts[2].display_name | Endoderm |
| concepts[3].id | https://openalex.org/C87073359 |
| concepts[3].level | 3 |
| concepts[3].score | 0.6314440369606018 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q33196 |
| concepts[3].display_name | Embryogenesis |
| concepts[4].id | https://openalex.org/C145103041 |
| concepts[4].level | 3 |
| concepts[4].score | 0.6233475208282471 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q1151519 |
| concepts[4].display_name | Embryonic stem cell |
| concepts[5].id | https://openalex.org/C134305767 |
| concepts[5].level | 3 |
| concepts[5].score | 0.555348813533783 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q725508 |
| concepts[5].display_name | Somatic cell |
| concepts[6].id | https://openalex.org/C109159458 |
| concepts[6].level | 3 |
| concepts[6].score | 0.5539108514785767 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q919283 |
| concepts[6].display_name | Haematopoiesis |
| concepts[7].id | https://openalex.org/C2779329299 |
| concepts[7].level | 4 |
| concepts[7].score | 0.4487817883491516 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q272474 |
| concepts[7].display_name | Ectoderm |
| concepts[8].id | https://openalex.org/C54355233 |
| concepts[8].level | 1 |
| concepts[8].score | 0.4478524327278137 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[8].display_name | Genetics |
| concepts[9].id | https://openalex.org/C95444343 |
| concepts[9].level | 1 |
| concepts[9].score | 0.3618374466896057 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[9].display_name | Cell biology |
| concepts[10].id | https://openalex.org/C196843134 |
| concepts[10].level | 2 |
| concepts[10].score | 0.2811572849750519 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q33196 |
| concepts[10].display_name | Embryo |
| concepts[11].id | https://openalex.org/C28328180 |
| concepts[11].level | 2 |
| concepts[11].score | 0.27937227487564087 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q48196 |
| concepts[11].display_name | Stem cell |
| concepts[12].id | https://openalex.org/C104317684 |
| concepts[12].level | 2 |
| concepts[12].score | 0.14133891463279724 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[12].display_name | Gene |
| keywords[0].id | https://openalex.org/keywords/biology |
| keywords[0].score | 0.8076901435852051 |
| keywords[0].display_name | Biology |
| keywords[1].id | https://openalex.org/keywords/mesoderm |
| keywords[1].score | 0.7604467272758484 |
| keywords[1].display_name | Mesoderm |
| keywords[2].id | https://openalex.org/keywords/endoderm |
| keywords[2].score | 0.6339001655578613 |
| keywords[2].display_name | Endoderm |
| keywords[3].id | https://openalex.org/keywords/embryogenesis |
| keywords[3].score | 0.6314440369606018 |
| keywords[3].display_name | Embryogenesis |
| keywords[4].id | https://openalex.org/keywords/embryonic-stem-cell |
| keywords[4].score | 0.6233475208282471 |
| keywords[4].display_name | Embryonic stem cell |
| keywords[5].id | https://openalex.org/keywords/somatic-cell |
| keywords[5].score | 0.555348813533783 |
| keywords[5].display_name | Somatic cell |
| keywords[6].id | https://openalex.org/keywords/haematopoiesis |
| keywords[6].score | 0.5539108514785767 |
| keywords[6].display_name | Haematopoiesis |
| keywords[7].id | https://openalex.org/keywords/ectoderm |
| keywords[7].score | 0.4487817883491516 |
| keywords[7].display_name | Ectoderm |
| keywords[8].id | https://openalex.org/keywords/genetics |
| keywords[8].score | 0.4478524327278137 |
| keywords[8].display_name | Genetics |
| keywords[9].id | https://openalex.org/keywords/cell-biology |
| keywords[9].score | 0.3618374466896057 |
| keywords[9].display_name | Cell biology |
| keywords[10].id | https://openalex.org/keywords/embryo |
| keywords[10].score | 0.2811572849750519 |
| keywords[10].display_name | Embryo |
| keywords[11].id | https://openalex.org/keywords/stem-cell |
| keywords[11].score | 0.27937227487564087 |
| keywords[11].display_name | Stem cell |
| keywords[12].id | https://openalex.org/keywords/gene |
| keywords[12].score | 0.14133891463279724 |
| keywords[12].display_name | Gene |
| language | en |
| locations[0].id | doi:10.1101/2020.05.29.088765 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4306402567 |
| locations[0].source.issn | |
| locations[0].source.type | repository |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | |
| locations[0].source.is_core | False |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| locations[0].source.host_organization | https://openalex.org/I2750212522 |
| locations[0].source.host_organization_name | Cold Spring Harbor Laboratory |
| locations[0].source.host_organization_lineage | https://openalex.org/I2750212522 |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.biorxiv.org/content/biorxiv/early/2020/05/30/2020.05.29.088765.full.pdf |
| locations[0].version | acceptedVersion |
| locations[0].raw_type | posted-content |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | False |
| locations[0].raw_source_name | |
| locations[0].landing_page_url | https://doi.org/10.1101/2020.05.29.088765 |
| indexed_in | crossref |
| authorships[0].author.id | https://openalex.org/A5006194205 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-5320-8193 |
| authorships[0].author.display_name | Michael Spencer Chapman |
| authorships[0].countries | GB |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I2802466933 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Haematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I2802476451 |
| authorships[0].affiliations[1].raw_affiliation_string | Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB0 SA, UK |
| authorships[0].affiliations[2].institution_ids | https://openalex.org/I153355300, https://openalex.org/I2801748203 |
| authorships[0].affiliations[2].raw_affiliation_string | Department of Haematology, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, W1 0HS, UK |
| authorships[0].institutions[0].id | https://openalex.org/I2802466933 |
| authorships[0].institutions[0].ror | https://ror.org/04v54gj93 |
| authorships[0].institutions[0].type | healthcare |
| authorships[0].institutions[0].lineage | https://openalex.org/I2802466933 |
| authorships[0].institutions[0].country_code | GB |
| authorships[0].institutions[0].display_name | Cambridge University Hospitals NHS Foundation Trust |
| authorships[0].institutions[1].id | https://openalex.org/I2801748203 |
| authorships[0].institutions[1].ror | https://ror.org/05jg8yp15 |
| authorships[0].institutions[1].type | healthcare |
| authorships[0].institutions[1].lineage | https://openalex.org/I153355300, https://openalex.org/I2801748203 |
| authorships[0].institutions[1].country_code | GB |
| authorships[0].institutions[1].display_name | Hammersmith Hospital |
| authorships[0].institutions[2].id | https://openalex.org/I153355300 |
| authorships[0].institutions[2].ror | https://ror.org/056ffv270 |
| authorships[0].institutions[2].type | healthcare |
| authorships[0].institutions[2].lineage | https://openalex.org/I153355300 |
| authorships[0].institutions[2].country_code | GB |
| authorships[0].institutions[2].display_name | Imperial College Healthcare NHS Trust |
| authorships[0].institutions[3].id | https://openalex.org/I2802476451 |
| authorships[0].institutions[3].ror | https://ror.org/05cy4wa09 |
| authorships[0].institutions[3].type | nonprofit |
| authorships[0].institutions[3].lineage | https://openalex.org/I2802476451, https://openalex.org/I87048295 |
| authorships[0].institutions[3].country_code | GB |
| authorships[0].institutions[3].display_name | Wellcome Sanger Institute |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Michael Spencer Chapman |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Haematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK, Department of Haematology, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, W1 0HS, UK, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB0 SA, UK |
| authorships[1].author.id | https://openalex.org/A5026815818 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-2573-1382 |
| authorships[1].author.display_name | Anna Maria Ranzoni |
| authorships[1].countries | GB |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I2802476451 |
| authorships[1].affiliations[0].raw_affiliation_string | Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB0 SA, UK |
| authorships[1].affiliations[1].institution_ids | https://openalex.org/I21196054, https://openalex.org/I90344618 |
| authorships[1].affiliations[1].raw_affiliation_string | Wellcome Trust – Medical Research Council Cambridge Stem Cell Institute, Cambridge, CB2 0AW, UK |
| authorships[1].affiliations[2].institution_ids | https://openalex.org/I241749 |
| authorships[1].affiliations[2].raw_affiliation_string | University of Cambridge, Department of Haematology, Cambridge, CB2 0AW, UK |
| authorships[1].institutions[0].id | https://openalex.org/I90344618 |
| authorships[1].institutions[0].ror | https://ror.org/03x94j517 |
| authorships[1].institutions[0].type | government |
| authorships[1].institutions[0].lineage | https://openalex.org/I4210087105, https://openalex.org/I90344618 |
| authorships[1].institutions[0].country_code | GB |
| authorships[1].institutions[0].display_name | Medical Research Council |
| authorships[1].institutions[1].id | https://openalex.org/I241749 |
| authorships[1].institutions[1].ror | https://ror.org/013meh722 |
| authorships[1].institutions[1].type | education |
| authorships[1].institutions[1].lineage | https://openalex.org/I241749 |
| authorships[1].institutions[1].country_code | GB |
| authorships[1].institutions[1].display_name | University of Cambridge |
| authorships[1].institutions[2].id | https://openalex.org/I2802476451 |
| authorships[1].institutions[2].ror | https://ror.org/05cy4wa09 |
| authorships[1].institutions[2].type | nonprofit |
| authorships[1].institutions[2].lineage | https://openalex.org/I2802476451, https://openalex.org/I87048295 |
| authorships[1].institutions[2].country_code | GB |
| authorships[1].institutions[2].display_name | Wellcome Sanger Institute |
| authorships[1].institutions[3].id | https://openalex.org/I21196054 |
| authorships[1].institutions[3].ror | https://ror.org/05nz0zp31 |
| authorships[1].institutions[3].type | facility |
| authorships[1].institutions[3].lineage | https://openalex.org/I21196054, https://openalex.org/I241749, https://openalex.org/I4210087105, https://openalex.org/I87048295, https://openalex.org/I90344618 |
| authorships[1].institutions[3].country_code | GB |
| authorships[1].institutions[3].display_name | Wellcome/MRC Cambridge Stem Cell Institute |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Anna Maria Ranzoni |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | University of Cambridge, Department of Haematology, Cambridge, CB2 0AW, UK, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB0 SA, UK, Wellcome Trust – Medical Research Council Cambridge Stem Cell Institute, Cambridge, CB2 0AW, UK |
| authorships[2].author.id | https://openalex.org/A5061715518 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | Brynelle Myers |
| authorships[2].countries | GB |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I2802476451 |
| authorships[2].affiliations[0].raw_affiliation_string | Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB0 SA, UK |
| authorships[2].affiliations[1].institution_ids | https://openalex.org/I21196054, https://openalex.org/I90344618 |
| authorships[2].affiliations[1].raw_affiliation_string | Wellcome Trust – Medical Research Council Cambridge Stem Cell Institute, Cambridge, CB2 0AW, UK |
| authorships[2].affiliations[2].institution_ids | https://openalex.org/I241749 |
| authorships[2].affiliations[2].raw_affiliation_string | University of Cambridge, Department of Haematology, Cambridge, CB2 0AW, UK |
| authorships[2].institutions[0].id | https://openalex.org/I90344618 |
| authorships[2].institutions[0].ror | https://ror.org/03x94j517 |
| authorships[2].institutions[0].type | government |
| authorships[2].institutions[0].lineage | https://openalex.org/I4210087105, https://openalex.org/I90344618 |
| authorships[2].institutions[0].country_code | GB |
| authorships[2].institutions[0].display_name | Medical Research Council |
| authorships[2].institutions[1].id | https://openalex.org/I241749 |
| authorships[2].institutions[1].ror | https://ror.org/013meh722 |
| authorships[2].institutions[1].type | education |
| authorships[2].institutions[1].lineage | https://openalex.org/I241749 |
| authorships[2].institutions[1].country_code | GB |
| authorships[2].institutions[1].display_name | University of Cambridge |
| authorships[2].institutions[2].id | https://openalex.org/I2802476451 |
| authorships[2].institutions[2].ror | https://ror.org/05cy4wa09 |
| authorships[2].institutions[2].type | nonprofit |
| authorships[2].institutions[2].lineage | https://openalex.org/I2802476451, https://openalex.org/I87048295 |
| authorships[2].institutions[2].country_code | GB |
| authorships[2].institutions[2].display_name | Wellcome Sanger Institute |
| authorships[2].institutions[3].id | https://openalex.org/I21196054 |
| authorships[2].institutions[3].ror | https://ror.org/05nz0zp31 |
| authorships[2].institutions[3].type | facility |
| authorships[2].institutions[3].lineage | https://openalex.org/I21196054, https://openalex.org/I241749, https://openalex.org/I4210087105, https://openalex.org/I87048295, https://openalex.org/I90344618 |
| authorships[2].institutions[3].country_code | GB |
| authorships[2].institutions[3].display_name | Wellcome/MRC Cambridge Stem Cell Institute |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Brynelle Myers |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | University of Cambridge, Department of Haematology, Cambridge, CB2 0AW, UK, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB0 SA, UK, Wellcome Trust – Medical Research Council Cambridge Stem Cell Institute, Cambridge, CB2 0AW, UK |
| authorships[3].author.id | https://openalex.org/A5102935987 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-3541-5586 |
| authorships[3].author.display_name | Nick Williams |
| authorships[3].countries | GB |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I2802476451 |
| authorships[3].affiliations[0].raw_affiliation_string | Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB0 SA, UK |
| authorships[3].institutions[0].id | https://openalex.org/I2802476451 |
| authorships[3].institutions[0].ror | https://ror.org/05cy4wa09 |
| authorships[3].institutions[0].type | nonprofit |
| authorships[3].institutions[0].lineage | https://openalex.org/I2802476451, https://openalex.org/I87048295 |
| authorships[3].institutions[0].country_code | GB |
| authorships[3].institutions[0].display_name | Wellcome Sanger Institute |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Nick Williams |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB0 SA, UK |
| authorships[4].author.id | https://openalex.org/A5058208718 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-5826-3554 |
| authorships[4].author.display_name | Tim H. H. Coorens |
| authorships[4].countries | GB |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I2802476451 |
| authorships[4].affiliations[0].raw_affiliation_string | Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB0 SA, UK |
| authorships[4].institutions[0].id | https://openalex.org/I2802476451 |
| authorships[4].institutions[0].ror | https://ror.org/05cy4wa09 |
| authorships[4].institutions[0].type | nonprofit |
| authorships[4].institutions[0].lineage | https://openalex.org/I2802476451, https://openalex.org/I87048295 |
| authorships[4].institutions[0].country_code | GB |
| authorships[4].institutions[0].display_name | Wellcome Sanger Institute |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Tim Coorens |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB0 SA, UK |
| authorships[5].author.id | https://openalex.org/A5035554455 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-2475-5737 |
| authorships[5].author.display_name | Emily Mitchell |
| authorships[5].countries | GB |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I2802466933 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Haematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK |
| authorships[5].affiliations[1].institution_ids | https://openalex.org/I2802476451 |
| authorships[5].affiliations[1].raw_affiliation_string | Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB0 SA, UK |
| authorships[5].institutions[0].id | https://openalex.org/I2802466933 |
| authorships[5].institutions[0].ror | https://ror.org/04v54gj93 |
| authorships[5].institutions[0].type | healthcare |
| authorships[5].institutions[0].lineage | https://openalex.org/I2802466933 |
| authorships[5].institutions[0].country_code | GB |
| authorships[5].institutions[0].display_name | Cambridge University Hospitals NHS Foundation Trust |
| authorships[5].institutions[1].id | https://openalex.org/I2802476451 |
| authorships[5].institutions[1].ror | https://ror.org/05cy4wa09 |
| authorships[5].institutions[1].type | nonprofit |
| authorships[5].institutions[1].lineage | https://openalex.org/I2802476451, https://openalex.org/I87048295 |
| authorships[5].institutions[1].country_code | GB |
| authorships[5].institutions[1].display_name | Wellcome Sanger Institute |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Emily Mitchell |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Haematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB0 SA, UK |
| authorships[6].author.id | https://openalex.org/A5062249209 |
| authorships[6].author.orcid | https://orcid.org/0000-0001-5803-1035 |
| authorships[6].author.display_name | Timothy Butler |
| authorships[6].countries | GB |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I2802476451 |
| authorships[6].affiliations[0].raw_affiliation_string | Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB0 SA, UK |
| authorships[6].institutions[0].id | https://openalex.org/I2802476451 |
| authorships[6].institutions[0].ror | https://ror.org/05cy4wa09 |
| authorships[6].institutions[0].type | nonprofit |
| authorships[6].institutions[0].lineage | https://openalex.org/I2802476451, https://openalex.org/I87048295 |
| authorships[6].institutions[0].country_code | GB |
| authorships[6].institutions[0].display_name | Wellcome Sanger Institute |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Timothy Butler |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB0 SA, UK |
| authorships[7].author.id | https://openalex.org/A5108347145 |
| authorships[7].author.orcid | |
| authorships[7].author.display_name | Kevin J. Dawson |
| authorships[7].countries | GB |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I2802476451 |
| authorships[7].affiliations[0].raw_affiliation_string | Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB0 SA, UK |
| authorships[7].institutions[0].id | https://openalex.org/I2802476451 |
| authorships[7].institutions[0].ror | https://ror.org/05cy4wa09 |
| authorships[7].institutions[0].type | nonprofit |
| authorships[7].institutions[0].lineage | https://openalex.org/I2802476451, https://openalex.org/I87048295 |
| authorships[7].institutions[0].country_code | GB |
| authorships[7].institutions[0].display_name | Wellcome Sanger Institute |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Kevin J Dawson |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB0 SA, UK |
| authorships[8].author.id | https://openalex.org/A5076250197 |
| authorships[8].author.orcid | |
| authorships[8].author.display_name | Yvette Hooks |
| authorships[8].countries | GB |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I2802476451 |
| authorships[8].affiliations[0].raw_affiliation_string | Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB0 SA, UK |
| authorships[8].institutions[0].id | https://openalex.org/I2802476451 |
| authorships[8].institutions[0].ror | https://ror.org/05cy4wa09 |
| authorships[8].institutions[0].type | nonprofit |
| authorships[8].institutions[0].lineage | https://openalex.org/I2802476451, https://openalex.org/I87048295 |
| authorships[8].institutions[0].country_code | GB |
| authorships[8].institutions[0].display_name | Wellcome Sanger Institute |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Yvette Hooks |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB0 SA, UK |
| authorships[9].author.id | https://openalex.org/A5074884237 |
| authorships[9].author.orcid | https://orcid.org/0000-0001-5315-516X |
| authorships[9].author.display_name | Luiza Moore |
| authorships[9].countries | GB |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I2802476451 |
| authorships[9].affiliations[0].raw_affiliation_string | Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB0 SA, UK |
| authorships[9].affiliations[1].institution_ids | https://openalex.org/I2802466933 |
| authorships[9].affiliations[1].raw_affiliation_string | Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK |
| authorships[9].institutions[0].id | https://openalex.org/I2802466933 |
| authorships[9].institutions[0].ror | https://ror.org/04v54gj93 |
| authorships[9].institutions[0].type | healthcare |
| authorships[9].institutions[0].lineage | https://openalex.org/I2802466933 |
| authorships[9].institutions[0].country_code | GB |
| authorships[9].institutions[0].display_name | Cambridge University Hospitals NHS Foundation Trust |
| authorships[9].institutions[1].id | https://openalex.org/I2802476451 |
| authorships[9].institutions[1].ror | https://ror.org/05cy4wa09 |
| authorships[9].institutions[1].type | nonprofit |
| authorships[9].institutions[1].lineage | https://openalex.org/I2802476451, https://openalex.org/I87048295 |
| authorships[9].institutions[1].country_code | GB |
| authorships[9].institutions[1].display_name | Wellcome Sanger Institute |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Luiza Moore |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB0 SA, UK |
| authorships[10].author.id | https://openalex.org/A5087775013 |
| authorships[10].author.orcid | https://orcid.org/0000-0001-7122-4608 |
| authorships[10].author.display_name | Jyoti Nangalia |
| authorships[10].countries | GB |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I2802476451 |
| authorships[10].affiliations[0].raw_affiliation_string | Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB0 SA, UK |
| authorships[10].affiliations[1].institution_ids | https://openalex.org/I241749 |
| authorships[10].affiliations[1].raw_affiliation_string | University of Cambridge, Department of Haematology, Cambridge, CB2 0AW, UK |
| authorships[10].affiliations[2].institution_ids | https://openalex.org/I21196054, https://openalex.org/I90344618 |
| authorships[10].affiliations[2].raw_affiliation_string | Wellcome Trust – Medical Research Council Cambridge Stem Cell Institute, Cambridge, CB2 0AW, UK |
| authorships[10].institutions[0].id | https://openalex.org/I90344618 |
| authorships[10].institutions[0].ror | https://ror.org/03x94j517 |
| authorships[10].institutions[0].type | government |
| authorships[10].institutions[0].lineage | https://openalex.org/I4210087105, https://openalex.org/I90344618 |
| authorships[10].institutions[0].country_code | GB |
| authorships[10].institutions[0].display_name | Medical Research Council |
| authorships[10].institutions[1].id | https://openalex.org/I241749 |
| authorships[10].institutions[1].ror | https://ror.org/013meh722 |
| authorships[10].institutions[1].type | education |
| authorships[10].institutions[1].lineage | https://openalex.org/I241749 |
| authorships[10].institutions[1].country_code | GB |
| authorships[10].institutions[1].display_name | University of Cambridge |
| authorships[10].institutions[2].id | https://openalex.org/I2802476451 |
| authorships[10].institutions[2].ror | https://ror.org/05cy4wa09 |
| authorships[10].institutions[2].type | nonprofit |
| authorships[10].institutions[2].lineage | https://openalex.org/I2802476451, https://openalex.org/I87048295 |
| authorships[10].institutions[2].country_code | GB |
| authorships[10].institutions[2].display_name | Wellcome Sanger Institute |
| authorships[10].institutions[3].id | https://openalex.org/I21196054 |
| authorships[10].institutions[3].ror | https://ror.org/05nz0zp31 |
| authorships[10].institutions[3].type | facility |
| authorships[10].institutions[3].lineage | https://openalex.org/I21196054, https://openalex.org/I241749, https://openalex.org/I4210087105, https://openalex.org/I87048295, https://openalex.org/I90344618 |
| authorships[10].institutions[3].country_code | GB |
| authorships[10].institutions[3].display_name | Wellcome/MRC Cambridge Stem Cell Institute |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Jyoti Nangalia |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | University of Cambridge, Department of Haematology, Cambridge, CB2 0AW, UK, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB0 SA, UK, Wellcome Trust – Medical Research Council Cambridge Stem Cell Institute, Cambridge, CB2 0AW, UK |
| authorships[11].author.id | https://openalex.org/A5036787245 |
| authorships[11].author.orcid | https://orcid.org/0000-0002-6237-7159 |
| authorships[11].author.display_name | Philip S. Robinson |
| authorships[11].countries | GB |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I241749 |
| authorships[11].affiliations[0].raw_affiliation_string | University of Cambridge, Department of Paediatrics, Cambridge, CB2 0QQ, UK |
| authorships[11].affiliations[1].institution_ids | https://openalex.org/I2802476451 |
| authorships[11].affiliations[1].raw_affiliation_string | Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB0 SA, UK |
| authorships[11].institutions[0].id | https://openalex.org/I241749 |
| authorships[11].institutions[0].ror | https://ror.org/013meh722 |
| authorships[11].institutions[0].type | education |
| authorships[11].institutions[0].lineage | https://openalex.org/I241749 |
| authorships[11].institutions[0].country_code | GB |
| authorships[11].institutions[0].display_name | University of Cambridge |
| authorships[11].institutions[1].id | https://openalex.org/I2802476451 |
| authorships[11].institutions[1].ror | https://ror.org/05cy4wa09 |
| authorships[11].institutions[1].type | nonprofit |
| authorships[11].institutions[1].lineage | https://openalex.org/I2802476451, https://openalex.org/I87048295 |
| authorships[11].institutions[1].country_code | GB |
| authorships[11].institutions[1].display_name | Wellcome Sanger Institute |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Philip S Robinson |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | University of Cambridge, Department of Paediatrics, Cambridge, CB2 0QQ, UK, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB0 SA, UK |
| authorships[12].author.id | https://openalex.org/A5042716386 |
| authorships[12].author.orcid | |
| authorships[12].author.display_name | Elizabeth Hook |
| authorships[12].countries | GB |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I2802466933 |
| authorships[12].affiliations[0].raw_affiliation_string | Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK |
| authorships[12].institutions[0].id | https://openalex.org/I2802466933 |
| authorships[12].institutions[0].ror | https://ror.org/04v54gj93 |
| authorships[12].institutions[0].type | healthcare |
| authorships[12].institutions[0].lineage | https://openalex.org/I2802466933 |
| authorships[12].institutions[0].country_code | GB |
| authorships[12].institutions[0].display_name | Cambridge University Hospitals NHS Foundation Trust |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Elizabeth Hook |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK |
| authorships[13].author.id | https://openalex.org/A5026738636 |
| authorships[13].author.orcid | https://orcid.org/0000-0002-3921-0510 |
| authorships[13].author.display_name | Peter J. Campbell |
| authorships[13].countries | GB |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I21196054, https://openalex.org/I90344618 |
| authorships[13].affiliations[0].raw_affiliation_string | Wellcome Trust – Medical Research Council Cambridge Stem Cell Institute, Cambridge, CB2 0AW, UK |
| authorships[13].affiliations[1].institution_ids | https://openalex.org/I2802476451 |
| authorships[13].affiliations[1].raw_affiliation_string | Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB0 SA, UK |
| authorships[13].institutions[0].id | https://openalex.org/I90344618 |
| authorships[13].institutions[0].ror | https://ror.org/03x94j517 |
| authorships[13].institutions[0].type | government |
| authorships[13].institutions[0].lineage | https://openalex.org/I4210087105, https://openalex.org/I90344618 |
| authorships[13].institutions[0].country_code | GB |
| authorships[13].institutions[0].display_name | Medical Research Council |
| authorships[13].institutions[1].id | https://openalex.org/I2802476451 |
| authorships[13].institutions[1].ror | https://ror.org/05cy4wa09 |
| authorships[13].institutions[1].type | nonprofit |
| authorships[13].institutions[1].lineage | https://openalex.org/I2802476451, https://openalex.org/I87048295 |
| authorships[13].institutions[1].country_code | GB |
| authorships[13].institutions[1].display_name | Wellcome Sanger Institute |
| authorships[13].institutions[2].id | https://openalex.org/I21196054 |
| authorships[13].institutions[2].ror | https://ror.org/05nz0zp31 |
| authorships[13].institutions[2].type | facility |
| authorships[13].institutions[2].lineage | https://openalex.org/I21196054, https://openalex.org/I241749, https://openalex.org/I4210087105, https://openalex.org/I87048295, https://openalex.org/I90344618 |
| authorships[13].institutions[2].country_code | GB |
| authorships[13].institutions[2].display_name | Wellcome/MRC Cambridge Stem Cell Institute |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Peter J Campbell |
| authorships[13].is_corresponding | True |
| authorships[13].raw_affiliation_strings | Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB0 SA, UK, Wellcome Trust – Medical Research Council Cambridge Stem Cell Institute, Cambridge, CB2 0AW, UK |
| authorships[14].author.id | https://openalex.org/A5036718218 |
| authorships[14].author.orcid | https://orcid.org/0000-0003-3204-9311 |
| authorships[14].author.display_name | Ana Cvejic |
| authorships[14].countries | GB |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I2802476451 |
| authorships[14].affiliations[0].raw_affiliation_string | Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB0 SA, UK |
| authorships[14].affiliations[1].institution_ids | https://openalex.org/I241749 |
| authorships[14].affiliations[1].raw_affiliation_string | University of Cambridge, Department of Haematology, Cambridge, CB2 0AW, UK |
| authorships[14].affiliations[2].institution_ids | https://openalex.org/I21196054, https://openalex.org/I90344618 |
| authorships[14].affiliations[2].raw_affiliation_string | Wellcome Trust – Medical Research Council Cambridge Stem Cell Institute, Cambridge, CB2 0AW, UK |
| authorships[14].institutions[0].id | https://openalex.org/I90344618 |
| authorships[14].institutions[0].ror | https://ror.org/03x94j517 |
| authorships[14].institutions[0].type | government |
| authorships[14].institutions[0].lineage | https://openalex.org/I4210087105, https://openalex.org/I90344618 |
| authorships[14].institutions[0].country_code | GB |
| authorships[14].institutions[0].display_name | Medical Research Council |
| authorships[14].institutions[1].id | https://openalex.org/I241749 |
| authorships[14].institutions[1].ror | https://ror.org/013meh722 |
| authorships[14].institutions[1].type | education |
| authorships[14].institutions[1].lineage | https://openalex.org/I241749 |
| authorships[14].institutions[1].country_code | GB |
| authorships[14].institutions[1].display_name | University of Cambridge |
| authorships[14].institutions[2].id | https://openalex.org/I2802476451 |
| authorships[14].institutions[2].ror | https://ror.org/05cy4wa09 |
| authorships[14].institutions[2].type | nonprofit |
| authorships[14].institutions[2].lineage | https://openalex.org/I2802476451, https://openalex.org/I87048295 |
| authorships[14].institutions[2].country_code | GB |
| authorships[14].institutions[2].display_name | Wellcome Sanger Institute |
| authorships[14].institutions[3].id | https://openalex.org/I21196054 |
| authorships[14].institutions[3].ror | https://ror.org/05nz0zp31 |
| authorships[14].institutions[3].type | facility |
| authorships[14].institutions[3].lineage | https://openalex.org/I21196054, https://openalex.org/I241749, https://openalex.org/I4210087105, https://openalex.org/I87048295, https://openalex.org/I90344618 |
| authorships[14].institutions[3].country_code | GB |
| authorships[14].institutions[3].display_name | Wellcome/MRC Cambridge Stem Cell Institute |
| authorships[14].author_position | last |
| authorships[14].raw_author_name | Ana Cvejic |
| authorships[14].is_corresponding | True |
| authorships[14].raw_affiliation_strings | University of Cambridge, Department of Haematology, Cambridge, CB2 0AW, UK, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB0 SA, UK, Wellcome Trust – Medical Research Council Cambridge Stem Cell Institute, Cambridge, CB2 0AW, UK |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.biorxiv.org/content/biorxiv/early/2020/05/30/2020.05.29.088765.full.pdf |
| open_access.oa_status | green |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Lineage tracing of human embryonic development and foetal haematopoiesis through somatic mutations |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11289 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9994000196456909 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1312 |
| primary_topic.subfield.display_name | Molecular Biology |
| primary_topic.display_name | Single-cell and spatial transcriptomics |
| related_works | https://openalex.org/W2158713637, https://openalex.org/W2417464902, https://openalex.org/W4238233102, https://openalex.org/W1978047246, https://openalex.org/W2401777613, https://openalex.org/W2024089616, https://openalex.org/W2809024494, https://openalex.org/W2095035432, https://openalex.org/W1989641503, https://openalex.org/W2146242051 |
| cited_by_count | 6 |
| counts_by_year[0].year | 2021 |
| counts_by_year[0].cited_by_count | 2 |
| counts_by_year[1].year | 2020 |
| counts_by_year[1].cited_by_count | 4 |
| locations_count | 1 |
| best_oa_location.id | doi:10.1101/2020.05.29.088765 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4306402567 |
| best_oa_location.source.issn | |
| best_oa_location.source.type | repository |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | |
| best_oa_location.source.is_core | False |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| best_oa_location.source.host_organization | https://openalex.org/I2750212522 |
| best_oa_location.source.host_organization_name | Cold Spring Harbor Laboratory |
| best_oa_location.source.host_organization_lineage | https://openalex.org/I2750212522 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.biorxiv.org/content/biorxiv/early/2020/05/30/2020.05.29.088765.full.pdf |
| best_oa_location.version | acceptedVersion |
| best_oa_location.raw_type | posted-content |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | |
| best_oa_location.landing_page_url | https://doi.org/10.1101/2020.05.29.088765 |
| primary_location.id | doi:10.1101/2020.05.29.088765 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4306402567 |
| primary_location.source.issn | |
| primary_location.source.type | repository |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | |
| primary_location.source.is_core | False |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| primary_location.source.host_organization | https://openalex.org/I2750212522 |
| primary_location.source.host_organization_name | Cold Spring Harbor Laboratory |
| primary_location.source.host_organization_lineage | https://openalex.org/I2750212522 |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.biorxiv.org/content/biorxiv/early/2020/05/30/2020.05.29.088765.full.pdf |
| primary_location.version | acceptedVersion |
| primary_location.raw_type | posted-content |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | False |
| primary_location.raw_source_name | |
| primary_location.landing_page_url | https://doi.org/10.1101/2020.05.29.088765 |
| publication_date | 2020-05-30 |
| publication_year | 2020 |
| referenced_works | https://openalex.org/W2100843179, https://openalex.org/W1992371996, https://openalex.org/W2728938210, https://openalex.org/W2292791236, https://openalex.org/W2070700342, https://openalex.org/W2571241168, https://openalex.org/W2061475018, https://openalex.org/W4301296333, https://openalex.org/W2132538606, https://openalex.org/W2524881570, https://openalex.org/W2987419797, https://openalex.org/W2889734305, https://openalex.org/W2114632170, https://openalex.org/W2101035019, https://openalex.org/W1989456683, https://openalex.org/W2173818354, https://openalex.org/W2603764892, https://openalex.org/W2805837610, https://openalex.org/W2905550051, https://openalex.org/W2998036617, https://openalex.org/W2996524386, https://openalex.org/W2051070310, https://openalex.org/W2802090556, https://openalex.org/W2602848567, https://openalex.org/W2981552021, https://openalex.org/W2121964616, https://openalex.org/W2217642920, https://openalex.org/W2564735272, https://openalex.org/W2787520586, https://openalex.org/W4246674695, https://openalex.org/W1987995801, https://openalex.org/W659148380 |
| referenced_works_count | 32 |
| abstract_inverted_index.8 | 37 |
| abstract_inverted_index.a | 56, 116, 131 |
| abstract_inverted_index.18 | 39, 77 |
| abstract_inverted_index.To | 1 |
| abstract_inverted_index.We | 62 |
| abstract_inverted_index.as | 82 |
| abstract_inverted_index.at | 102 |
| abstract_inverted_index.by | 76 |
| abstract_inverted_index.in | 65, 141 |
| abstract_inverted_index.of | 4, 26, 36, 48, 50, 59, 73, 88, 99, 105, 119, 134 |
| abstract_inverted_index.to | 54, 123 |
| abstract_inverted_index.we | 21, 84 |
| abstract_inverted_index.511 | 27 |
| abstract_inverted_index.Our | 108 |
| abstract_inverted_index.and | 38, 90, 95, 125, 138 |
| abstract_inverted_index.has | 12, 110 |
| abstract_inverted_index.our | 128 |
| abstract_inverted_index.set | 118 |
| abstract_inverted_index.the | 5, 86, 97, 135 |
| abstract_inverted_index.Here | 20 |
| abstract_inverted_index.been | 13 |
| abstract_inverted_index.data | 129 |
| abstract_inverted_index.deep | 45 |
| abstract_inverted_index.from | 32, 115 |
| abstract_inverted_index.pcw. | 78 |
| abstract_inverted_index.tens | 72 |
| abstract_inverted_index.that | 64, 112 |
| abstract_inverted_index.tree | 58 |
| abstract_inverted_index.used | 22 |
| abstract_inverted_index.with | 44 |
| abstract_inverted_index.(WGS) | 25 |
| abstract_inverted_index.(pcw) | 42 |
| abstract_inverted_index.Using | 79 |
| abstract_inverted_index.blood | 60, 100, 120, 140 |
| abstract_inverted_index.date, | 2 |
| abstract_inverted_index.found | 63 |
| abstract_inverted_index.human | 6, 34 |
| abstract_inverted_index.known | 51 |
| abstract_inverted_index.shown | 111 |
| abstract_inverted_index.these | 80 |
| abstract_inverted_index.timed | 85 |
| abstract_inverted_index.weeks | 41 |
| abstract_inverted_index.during | 9, 93 |
| abstract_inverted_index.foetal | 10 |
| abstract_inverted_index.mainly | 15 |
| abstract_inverted_index.number | 98 |
| abstract_inverted_index.origin | 53, 133 |
| abstract_inverted_index.stages | 104 |
| abstract_inverted_index.system | 8 |
| abstract_inverted_index.acquire | 71 |
| abstract_inverted_index.careful | 17 |
| abstract_inverted_index.coupled | 43 |
| abstract_inverted_index.derived | 29 |
| abstract_inverted_index.healthy | 33, 66 |
| abstract_inverted_index.humans. | 142 |
| abstract_inverted_index.smaller | 117 |
| abstract_inverted_index.somatic | 74 |
| abstract_inverted_index.support | 130 |
| abstract_inverted_index.through | 16 |
| abstract_inverted_index.tissues | 49, 92 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.Finally, | 127 |
| abstract_inverted_index.analysis | 109 |
| abstract_inverted_index.colonies | 31 |
| abstract_inverted_index.compared | 122 |
| abstract_inverted_index.ectoderm | 113 |
| abstract_inverted_index.endoderm | 124 |
| abstract_inverted_index.foetuses | 35 |
| abstract_inverted_index.mesoderm | 137 |
| abstract_inverted_index.ontogeny | 3 |
| abstract_inverted_index.targeted | 46 |
| abstract_inverted_index.barcodes, | 83 |
| abstract_inverted_index.different | 103 |
| abstract_inverted_index.embryonic | 52, 89, 106 |
| abstract_inverted_index.estimated | 96 |
| abstract_inverted_index.foetuses, | 67 |
| abstract_inverted_index.hypoblast | 132 |
| abstract_inverted_index.mesoderm. | 126 |
| abstract_inverted_index.mutations | 75, 81 |
| abstract_inverted_index.primitive | 139 |
| abstract_inverted_index.divergence | 87 |
| abstract_inverted_index.individual | 68 |
| abstract_inverted_index.originates | 114 |
| abstract_inverted_index.sequencing | 24, 47 |
| abstract_inverted_index.antecedents | 101, 121 |
| abstract_inverted_index.development | 11, 94 |
| abstract_inverted_index.microscopic | 18 |
| abstract_inverted_index.progenitors | 70 |
| abstract_inverted_index.reconstruct | 55 |
| abstract_inverted_index.single-cell | 28 |
| abstract_inverted_index.development. | 61, 107 |
| abstract_inverted_index.phylogenetic | 57 |
| abstract_inverted_index.whole-genome | 23 |
| abstract_inverted_index.characterized | 14 |
| abstract_inverted_index.observations. | 19 |
| abstract_inverted_index.haematopoietic | 7, 30, 69 |
| abstract_inverted_index.extra-embryonic | 91, 136 |
| abstract_inverted_index.post-conception | 40 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 93 |
| corresponding_author_ids | https://openalex.org/A5036718218, https://openalex.org/A5026738636 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 15 |
| corresponding_institution_ids | https://openalex.org/I21196054, https://openalex.org/I241749, https://openalex.org/I2802476451, https://openalex.org/I90344618 |
| citation_normalized_percentile.value | 0.63486027 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |