Linear Interaction Between Replication and Transcription Shapes DNA Break Dynamics at Recurrent DNA Break Clusters Article Swipe
Lorenzo Corazzi
,
Vivien Ionasz
,
Sergej Andrejev
,
Li-Chin Wang
,
Athanasios E Vouzas
,
Marco Giaisi
,
Giulia Di Muzio
,
Boyu Ding
,
Anna Marx
,
Jonas Henkenjohann
,
Michael M. Allers
,
David M. Gilbert
,
Pei‐Chi Wei
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1101/2023.08.22.554340
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1101/2023.08.22.554340
Recurrent DNA break clusters (RDCs) are replication-transcription collision hotspots; many are unique to neural progenitor cells. Through high-resolution replication sequencing and a capture-ligation assay in mouse neural progenitor cells experiencing replication stress, we unraveled the replication features dictating RDC location and orientation. Most RDCs occur at the replication forks traversing timing transition regions (TTRs), where sparse replication origins connect unidirectional forks. Leftward-moving forks generate telomere-connected DNA double-strand breaks (DSBs), while rightward-moving forks lead to centromere-connected DSBs. Strand-specific mapping for DNA-bound RNA revealed co-transcriptional dual-strand DNA:RNA hybrids present at a higher density in RDC than in other actively transcribed long genes. In addition, mapping RNA polymerase activity revealed that head-to-head interactions between replication and transcription machinery resulted in 60% DSB contribution to the head-on compared to 40% for co-directional. Our findings revealed TTR as a novel fragile class and highlighted how the linear interaction between transcription and replication impacts genome stability.
Related Topics
Concepts
Biology
DNA replication
Transcription (linguistics)
Origin recognition complex
Control of chromosome duplication
Genetics
Cell biology
DNA
Eukaryotic DNA replication
Molecular biology
Linguistics
Philosophy
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2023.08.22.554340
- https://www.biorxiv.org/content/biorxiv/early/2023/08/23/2023.08.22.554340.full.pdf
- OA Status
- green
- References
- 47
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4386089741
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4386089741Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2023.08.22.554340Digital Object Identifier
- Title
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Linear Interaction Between Replication and Transcription Shapes DNA Break Dynamics at Recurrent DNA Break ClustersWork title
- Type
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preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-08-23Full publication date if available
- Authors
-
Lorenzo Corazzi, Vivien Ionasz, Sergej Andrejev, Li-Chin Wang, Athanasios E Vouzas, Marco Giaisi, Giulia Di Muzio, Boyu Ding, Anna Marx, Jonas Henkenjohann, Michael M. Allers, David M. Gilbert, Pei‐Chi WeiList of authors in order
- Landing page
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https://doi.org/10.1101/2023.08.22.554340Publisher landing page
- PDF URL
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https://www.biorxiv.org/content/biorxiv/early/2023/08/23/2023.08.22.554340.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://www.biorxiv.org/content/biorxiv/early/2023/08/23/2023.08.22.554340.full.pdfDirect OA link when available
- Concepts
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Biology, DNA replication, Transcription (linguistics), Origin recognition complex, Control of chromosome duplication, Genetics, Cell biology, DNA, Eukaryotic DNA replication, Molecular biology, Linguistics, PhilosophyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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47Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.higher | 90 |
| abstract_inverted_index.linear | 142 |
| abstract_inverted_index.neural | 14, 27 |
| abstract_inverted_index.sparse | 56 |
| abstract_inverted_index.timing | 51 |
| abstract_inverted_index.unique | 12 |
| abstract_inverted_index.(DSBs), | 69 |
| abstract_inverted_index.(TTRs), | 54 |
| abstract_inverted_index.DNA:RNA | 85 |
| abstract_inverted_index.Through | 17 |
| abstract_inverted_index.between | 111, 144 |
| abstract_inverted_index.connect | 59 |
| abstract_inverted_index.density | 91 |
| abstract_inverted_index.fragile | 136 |
| abstract_inverted_index.head-on | 123 |
| abstract_inverted_index.hybrids | 86 |
| abstract_inverted_index.impacts | 148 |
| abstract_inverted_index.mapping | 78, 103 |
| abstract_inverted_index.origins | 58 |
| abstract_inverted_index.present | 87 |
| abstract_inverted_index.regions | 53 |
| abstract_inverted_index.stress, | 32 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.actively | 97 |
| abstract_inverted_index.activity | 106 |
| abstract_inverted_index.clusters | 4 |
| abstract_inverted_index.compared | 124 |
| abstract_inverted_index.features | 37 |
| abstract_inverted_index.findings | 130 |
| abstract_inverted_index.generate | 64 |
| abstract_inverted_index.location | 40 |
| abstract_inverted_index.resulted | 116 |
| abstract_inverted_index.revealed | 82, 107, 131 |
| abstract_inverted_index.DNA-bound | 80 |
| abstract_inverted_index.Recurrent | 1 |
| abstract_inverted_index.addition, | 102 |
| abstract_inverted_index.collision | 8 |
| abstract_inverted_index.dictating | 38 |
| abstract_inverted_index.hotspots; | 9 |
| abstract_inverted_index.machinery | 115 |
| abstract_inverted_index.unraveled | 34 |
| abstract_inverted_index.polymerase | 105 |
| abstract_inverted_index.progenitor | 15, 28 |
| abstract_inverted_index.sequencing | 20 |
| abstract_inverted_index.stability. | 150 |
| abstract_inverted_index.transition | 52 |
| abstract_inverted_index.traversing | 50 |
| abstract_inverted_index.dual-strand | 84 |
| abstract_inverted_index.highlighted | 139 |
| abstract_inverted_index.interaction | 143 |
| abstract_inverted_index.replication | 19, 31, 36, 48, 57, 112, 147 |
| abstract_inverted_index.transcribed | 98 |
| abstract_inverted_index.contribution | 120 |
| abstract_inverted_index.experiencing | 30 |
| abstract_inverted_index.head-to-head | 109 |
| abstract_inverted_index.interactions | 110 |
| abstract_inverted_index.orientation. | 42 |
| abstract_inverted_index.double-strand | 67 |
| abstract_inverted_index.transcription | 114, 145 |
| abstract_inverted_index.unidirectional | 60 |
| abstract_inverted_index.Leftward-moving | 62 |
| abstract_inverted_index.Strand-specific | 77 |
| abstract_inverted_index.co-directional. | 128 |
| abstract_inverted_index.high-resolution | 18 |
| abstract_inverted_index.capture-ligation | 23 |
| abstract_inverted_index.rightward-moving | 71 |
| abstract_inverted_index.co-transcriptional | 83 |
| abstract_inverted_index.telomere-connected | 65 |
| abstract_inverted_index.centromere-connected | 75 |
| abstract_inverted_index.replication-transcription | 7 |
| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5062497398 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 13 |
| corresponding_institution_ids | https://openalex.org/I17937529, https://openalex.org/I223822909, https://openalex.org/I4210113520 |
| citation_normalized_percentile.value | 0.28685211 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |