Linking Dementia Pathology and Alteration in Brain Activation to Complex Daily Functional Decline During the Preclinical Dementia Stages: Protocol for a Prospective Observational Cohort Study Article Swipe
Pierfilippo De Sanctis
,
Jeannette R. Mahoney
,
Johanna Wagner
,
Helena M. Blumen
,
Wenzhu Mowrey
,
Emmeline Ayers
,
Claudia Schneider
,
Natasha Orellana
,
Sophie Molholm
,
Joe Verghese
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.2196/56726
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.2196/56726
Background Progressive difficulty in performing everyday functional activities is a key diagnostic feature of dementia syndromes. However, not much is known about the neural signature of functional decline, particularly during the very early stages of dementia. Early intervention before overt impairment is observed offers the best hope of reducing the burdens of Alzheimer disease (AD) and other dementias. However, to justify early intervention, those at risk need to be detected earlier and more accurately. The decline in complex daily function (CdF) such as managing medications has been reported to precede impairment in basic activities of daily living (eg, eating and dressing). Objective Our goal is to establish the neural signature of decline in CdF during the preclinical dementia period. Methods Gait is central to many CdF and community-based activities. Hence, to elucidate the neural signature of CdF, we validated a novel electroencephalographic approach to measuring gait-related brain activation while participants perform complex gait-based functional tasks. We hypothesize that dementia-related pathology during the preclinical period activates a unique gait-related electroencephalographic (grEEG) pattern that predicts a subsequent decline in CdF. Results We provide preliminary findings showing that older adults reporting CdF limitations can be characterized by a unique gait-related neural signature: weaker sensorimotor and stronger motor control activation. This subsample also had smaller brain volume and white matter hyperintensities in regions affected early by dementia and engaged in less physical exercise. We propose a prospective observational cohort study in cognitively unimpaired older adults with and without subclinical AD (plasma amyloid-β) and vascular (white matter hyperintensities) pathologies. We aim to (1) establish the unique grEEG activation as the neural signature and predictor of decline in CdF during the preclinical dementia period; (2) determine associations between dementia-related pathologies and incidence of the neural signature of CdF; and (3) establish associations between a dementia risk factor, physical inactivity, and the neural signature of CdF. Conclusions By establishing the clinical relevance and biological basis of the neural signature of CdF decline, we aim to improve prediction during the preclinical stages of ADs and other dementias. Our approach has important research and translational implications because grEEG protocols are relatively inexpensive and portable, and predicting CdF decline may have real-world benefits. International Registered Report Identifier (IRRID) DERR1-10.2196/56726
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.2196/56726
- OA Status
- gold
- Cited By
- 1
- References
- 106
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4391986310
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4391986310Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.2196/56726Digital Object Identifier
- Title
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Linking Dementia Pathology and Alteration in Brain Activation to Complex Daily Functional Decline During the Preclinical Dementia Stages: Protocol for a Prospective Observational Cohort StudyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-02-20Full publication date if available
- Authors
-
Pierfilippo De Sanctis, Jeannette R. Mahoney, Johanna Wagner, Helena M. Blumen, Wenzhu Mowrey, Emmeline Ayers, Claudia Schneider, Natasha Orellana, Sophie Molholm, Joe VergheseList of authors in order
- Landing page
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https://doi.org/10.2196/56726Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
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https://doi.org/10.2196/56726Direct OA link when available
- Concepts
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Dementia, Observational study, Medicine, Cohort study, Preprint, Gerontology, Prospective cohort study, Cohort, Neuroscience, Psychology, Pathology, Disease, World Wide Web, Computer scienceTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
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2024: 1Per-year citation counts (last 5 years)
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106Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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