Lipid-driven Src self-association modulates its transformation capacity Article Swipe
Irrem-Laareb Mohammad
,
Marina I. Giannotti
,
Elise Fourgous
,
Yvan Boublik
,
Alejandro Fernández
,
Anabel‐Lise Le Roux
,
Audrey Sirvent
,
Marta Taulés
,
Serge Roche
,
Miquel Pons
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.26508/lsa.202403019
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.26508/lsa.202403019
Src tyrosine kinase regulates cell growth and adhesion through membrane signaling, and its deregulation is associated with cancer. Although active Src is anchored to the plasma membrane, the role of membrane lipids in its regulation remains unclear. Here, we report that Src self-associates via a lysine cluster in its SH4 region, a process mediated by lipids in human cells and in vitro. Mutation of the lysine cluster to arginine alters Src self-association and modulates its transforming function in human cells. Lipid-anchored micron-sized condensates of full-length Src form in supported homogeneous lipid bilayers (i.e., independently of lipid phase separation). Condensates also arise from the purified Src N-terminal regulatory element, which includes the myristoylated SH4 domain, the intrinsically disordered Unique domain, and the globular SH3 domain. However, the isolated SH4 domain alone forms small protein–lipid clusters rather than micron-sized condensates. Our findings reveal lipid-mediated kinase self-association as an additional regulatory mechanism for Src. This mechanism may also apply to other membrane-associated signaling proteins containing similar lysine clusters in their unstructured regions.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.26508/lsa.202403019
- https://www.life-science-alliance.org/content/lsa/8/5/e202403019.full.pdf
- OA Status
- gold
- References
- 46
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4408399152
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4408399152Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.26508/lsa.202403019Digital Object Identifier
- Title
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Lipid-driven Src self-association modulates its transformation capacityWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-03-13Full publication date if available
- Authors
-
Irrem-Laareb Mohammad, Marina I. Giannotti, Elise Fourgous, Yvan Boublik, Alejandro Fernández, Anabel‐Lise Le Roux, Audrey Sirvent, Marta Taulés, Serge Roche, Miquel PonsList of authors in order
- Landing page
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https://doi.org/10.26508/lsa.202403019Publisher landing page
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https://www.life-science-alliance.org/content/lsa/8/5/e202403019.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
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-
goldOpen access status per OpenAlex
- OA URL
-
https://www.life-science-alliance.org/content/lsa/8/5/e202403019.full.pdfDirect OA link when available
- Concepts
-
Proto-oncogene tyrosine-protein kinase Src, SH3 domain, Myristoylation, Cell biology, Lipid bilayer, Tyrosine kinase, Lipid raft, GRB2, Biochemistry, Phosphorylation, Biology, Chemistry, Signal transduction, MembraneTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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46Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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