Lipid-lowering statins and polyphenol-based supplementation: a scoping review on drug-food interaction potential Article Swipe
Rita Costa
,
Carolina Ferreira
,
André Luiz Moraes Alves
,
Sara Nunes
,
Flávio Reis
,
João O. Malva
,
Sofia Viana
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fphar.2025.1541871
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fphar.2025.1541871
Background Lifestyle modifications, particularly the adoption of healthy dietary patterns such as the Mediterranean Diet (MedDiet), are foundational in any treatment plan, including for patients prescribed first-line statin therapy for hypercholesterolemia. However, the rising popularity of MedDiet-associated foods and nutraceuticals among health-conscious consumers has raised concerns about their potential interactions with statins, potentially leading to adverse effects. One notable example involves polyphenol supplements, a class of anti-dyslipidemic phytochemicals known to influence statins’ pharmacokinetics. Still, whether chronic polyphenol exposure achieves plasma concentrations sufficient to alter statin pharmacokinetics in clinical settings is controverse. Moreover, it remains unclear which key biological targets are shared by both classes of molecules and how they mediate potential pharmacokinetic and pharmacodynamic interactions. This study aims to systematically map reported statin-polyphenol interactions and identify the principal biological targets involved, elucidating their impact on statin pharmacokinetics, efficacy, and toxicity. Methods A scoping review was conducted using the PubMed/Medline, Scopus, and Web of Science databases. This work was designed in accordance with PRISMA-ScR. The review protocol was registered in the Open Science Framework. Results Statin-polyphenol interactions were reported in 83.9% of the studies analyzed. The biological targets mediating these interactions play chief roles in statins’ cellular uptake (OATP/P-glycoprotein), metabolism (CYP450/intestinal esterases), and core mechanisms underlying statin action, namely, HMG-CoA reductase inhibition. Polyphenols significantly influenced statin pharmacokinetics, altering total drug exposure (AUC) and extent (Cmax), either by enhancement or inhibition, with apparently less impact on statins’ absorption rate (Tmax). At the clinical level, only five studies addressed statin-polyphenol interactions, yielding conflicting results on the potential enhancement of therapeutic efficacy and adverse effects. Discussion This work presents an integrated perspective on the cellular and molecular mechanisms underlying statin–polyphenol interactions. It highlights substantial inter-individual variability linked to conflicting evidence, from synergistic effects enabling lower statin doses and reduced adverse events to potential exacerbation of side effects. These findings underscore the need for controlled studies to clarify the clinical relevance of polyphenol-induced alterations in statin pharmacokinetics and pharmacodynamics. Such data are essential to develop evidence-based guidelines that may optimize statin therapy and support individualized treatment strategies. Systematic review registration identifier 10.17605/OSF.IO/DJW5G.
Related Topics
Concepts
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3389/fphar.2025.1541871
- https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1541871/pdf
- OA Status
- gold
- Cited By
- 3
- References
- 75
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4410905084
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4410905084Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fphar.2025.1541871Digital Object Identifier
- Title
-
Lipid-lowering statins and polyphenol-based supplementation: a scoping review on drug-food interaction potentialWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-05-30Full publication date if available
- Authors
-
Rita Costa, Carolina Ferreira, André Luiz Moraes Alves, Sara Nunes, Flávio Reis, João O. Malva, Sofia VianaList of authors in order
- Landing page
-
https://doi.org/10.3389/fphar.2025.1541871Publisher landing page
- PDF URL
-
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1541871/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1541871/pdfDirect OA link when available
- Concepts
-
Pharmacology, Drug, Medicine, Polyphenol, Traditional medicine, Chemistry, Biochemistry, AntioxidantTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
3Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3Per-year citation counts (last 5 years)
- References (count)
-
75Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4410905084 |
|---|---|
| doi | https://doi.org/10.3389/fphar.2025.1541871 |
| ids.doi | https://doi.org/10.3389/fphar.2025.1541871 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/40520191 |
| ids.openalex | https://openalex.org/W4410905084 |
| fwci | 13.72535572 |
| type | review |
| title | Lipid-lowering statins and polyphenol-based supplementation: a scoping review on drug-food interaction potential |
| biblio.issue | |
| biblio.volume | 16 |
| biblio.last_page | 1541871 |
| biblio.first_page | 1541871 |
| topics[0].id | https://openalex.org/T11140 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9984999895095825 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2712 |
| topics[0].subfield.display_name | Endocrinology, Diabetes and Metabolism |
| topics[0].display_name | Natural Antidiabetic Agents Studies |
| topics[1].id | https://openalex.org/T11318 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9954000115394592 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2734 |
| topics[1].subfield.display_name | Pathology and Forensic Medicine |
| topics[1].display_name | Phytoestrogen effects and research |
| topics[2].id | https://openalex.org/T10035 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9933000206947327 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2704 |
| topics[2].subfield.display_name | Biochemistry |
| topics[2].display_name | Phytochemicals and Antioxidant Activities |
| is_xpac | False |
| apc_list.value | 2950 |
| apc_list.currency | USD |
| apc_list.value_usd | 2950 |
| apc_paid.value | 2950 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 2950 |
| concepts[0].id | https://openalex.org/C98274493 |
| concepts[0].level | 1 |
| concepts[0].score | 0.5707804560661316 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q128406 |
| concepts[0].display_name | Pharmacology |
| concepts[1].id | https://openalex.org/C2780035454 |
| concepts[1].level | 2 |
| concepts[1].score | 0.5494623780250549 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q8386 |
| concepts[1].display_name | Drug |
| concepts[2].id | https://openalex.org/C71924100 |
| concepts[2].level | 0 |
| concepts[2].score | 0.5311825275421143 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[2].display_name | Medicine |
| concepts[3].id | https://openalex.org/C70899900 |
| concepts[3].level | 3 |
| concepts[3].score | 0.5029363036155701 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q290439 |
| concepts[3].display_name | Polyphenol |
| concepts[4].id | https://openalex.org/C556039675 |
| concepts[4].level | 1 |
| concepts[4].score | 0.4004102349281311 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q771035 |
| concepts[4].display_name | Traditional medicine |
| concepts[5].id | https://openalex.org/C185592680 |
| concepts[5].level | 0 |
| concepts[5].score | 0.25554972887039185 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[5].display_name | Chemistry |
| concepts[6].id | https://openalex.org/C55493867 |
| concepts[6].level | 1 |
| concepts[6].score | 0.16304942965507507 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[6].display_name | Biochemistry |
| concepts[7].id | https://openalex.org/C2778004101 |
| concepts[7].level | 2 |
| concepts[7].score | 0.14127424359321594 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q133948 |
| concepts[7].display_name | Antioxidant |
| keywords[0].id | https://openalex.org/keywords/pharmacology |
| keywords[0].score | 0.5707804560661316 |
| keywords[0].display_name | Pharmacology |
| keywords[1].id | https://openalex.org/keywords/drug |
| keywords[1].score | 0.5494623780250549 |
| keywords[1].display_name | Drug |
| keywords[2].id | https://openalex.org/keywords/medicine |
| keywords[2].score | 0.5311825275421143 |
| keywords[2].display_name | Medicine |
| keywords[3].id | https://openalex.org/keywords/polyphenol |
| keywords[3].score | 0.5029363036155701 |
| keywords[3].display_name | Polyphenol |
| keywords[4].id | https://openalex.org/keywords/traditional-medicine |
| keywords[4].score | 0.4004102349281311 |
| keywords[4].display_name | Traditional medicine |
| keywords[5].id | https://openalex.org/keywords/chemistry |
| keywords[5].score | 0.25554972887039185 |
| keywords[5].display_name | Chemistry |
| keywords[6].id | https://openalex.org/keywords/biochemistry |
| keywords[6].score | 0.16304942965507507 |
| keywords[6].display_name | Biochemistry |
| keywords[7].id | https://openalex.org/keywords/antioxidant |
| keywords[7].score | 0.14127424359321594 |
| keywords[7].display_name | Antioxidant |
| language | en |
| locations[0].id | doi:10.3389/fphar.2025.1541871 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S132108250 |
| locations[0].source.issn | 1663-9812 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1663-9812 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Frontiers in Pharmacology |
| locations[0].source.host_organization | https://openalex.org/P4310320527 |
| locations[0].source.host_organization_name | Frontiers Media |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320527 |
| locations[0].source.host_organization_lineage_names | Frontiers Media |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1541871/pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Frontiers in Pharmacology |
| locations[0].landing_page_url | https://doi.org/10.3389/fphar.2025.1541871 |
| locations[1].id | pmid:40520191 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Frontiers in pharmacology |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/40520191 |
| locations[2].id | pmh:oai:doaj.org/article:85f7586ba9694238b36e75adad1d0d5f |
| locations[2].is_oa | False |
| locations[2].source.id | https://openalex.org/S4306401280 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[2].source.host_organization | |
| locations[2].source.host_organization_name | |
| locations[2].license | |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | article |
| locations[2].license_id | |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Frontiers in Pharmacology, Vol 16 (2025) |
| locations[2].landing_page_url | https://doaj.org/article/85f7586ba9694238b36e75adad1d0d5f |
| locations[3].id | pmh:oai:europepmc.org:10974389 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S4306400806 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | Europe PMC (PubMed Central) |
| locations[3].source.host_organization | https://openalex.org/I1303153112 |
| locations[3].source.host_organization_name | European Bioinformatics Institute |
| locations[3].source.host_organization_lineage | https://openalex.org/I1303153112 |
| locations[3].license | other-oa |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | https://openalex.org/licenses/other-oa |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | |
| locations[3].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/12162920 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5015592209 |
| authorships[0].author.orcid | |
| authorships[0].author.display_name | Rita Costa |
| authorships[0].countries | PT |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I76903346 |
| authorships[0].affiliations[0].raw_affiliation_string | Coimbra Institute for Clinical and Biomedical Research (iCBR) - Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal. |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I76903346 |
| authorships[0].affiliations[1].raw_affiliation_string | Faculty of Medicine, Institute of Pharmacology and Experimental Therapeutics, University of Coimbra, Coimbra, Portugal. |
| authorships[0].affiliations[2].institution_ids | https://openalex.org/I76903346 |
| authorships[0].affiliations[2].raw_affiliation_string | Faculty of Medicine, Clinical Academic Center of Coimbra (CACC), University of Coimbra, Coimbra, Portugal. |
| authorships[0].affiliations[3].institution_ids | https://openalex.org/I293362453, https://openalex.org/I76903346 |
| authorships[0].affiliations[3].raw_affiliation_string | Polytechnic University of Coimbra, Coimbra, Portugal. |
| authorships[0].affiliations[4].institution_ids | https://openalex.org/I293362453, https://openalex.org/I76903346 |
| authorships[0].affiliations[4].raw_affiliation_string | Coimbra Health School, H&TRC- Health and Technology Research Center, Polytechnic University of Coimbra, Coimbra, Portugal. |
| authorships[0].institutions[0].id | https://openalex.org/I293362453 |
| authorships[0].institutions[0].ror | https://ror.org/01n8x4993 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I293362453 |
| authorships[0].institutions[0].country_code | PT |
| authorships[0].institutions[0].display_name | Polytechnic Institute of Coimbra |
| authorships[0].institutions[1].id | https://openalex.org/I76903346 |
| authorships[0].institutions[1].ror | https://ror.org/04z8k9a98 |
| authorships[0].institutions[1].type | education |
| authorships[0].institutions[1].lineage | https://openalex.org/I76903346 |
| authorships[0].institutions[1].country_code | PT |
| authorships[0].institutions[1].display_name | University of Coimbra |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Rita Costa |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Coimbra Health School, H&TRC- Health and Technology Research Center, Polytechnic University of Coimbra, Coimbra, Portugal., Coimbra Institute for Clinical and Biomedical Research (iCBR) - Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal., Faculty of Medicine, Clinical Academic Center of Coimbra (CACC), University of Coimbra, Coimbra, Portugal., Faculty of Medicine, Institute of Pharmacology and Experimental Therapeutics, University of Coimbra, Coimbra, Portugal., Polytechnic University of Coimbra, Coimbra, Portugal. |
| authorships[1].author.id | https://openalex.org/A5015650262 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-6511-6878 |
| authorships[1].author.display_name | Carolina Ferreira |
| authorships[1].countries | PT |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I76903346 |
| authorships[1].affiliations[0].raw_affiliation_string | Faculty of Medicine, Institute of Pharmacology and Experimental Therapeutics, University of Coimbra, Coimbra, Portugal. |
| authorships[1].affiliations[1].institution_ids | https://openalex.org/I76903346 |
| authorships[1].affiliations[1].raw_affiliation_string | Coimbra Institute for Clinical and Biomedical Research (iCBR) - Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal. |
| authorships[1].affiliations[2].institution_ids | https://openalex.org/I76903346 |
| authorships[1].affiliations[2].raw_affiliation_string | Faculty of Medicine, Clinical Academic Center of Coimbra (CACC), University of Coimbra, Coimbra, Portugal. |
| authorships[1].institutions[0].id | https://openalex.org/I76903346 |
| authorships[1].institutions[0].ror | https://ror.org/04z8k9a98 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I76903346 |
| authorships[1].institutions[0].country_code | PT |
| authorships[1].institutions[0].display_name | University of Coimbra |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Carolina Ferreira |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Coimbra Institute for Clinical and Biomedical Research (iCBR) - Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal., Faculty of Medicine, Clinical Academic Center of Coimbra (CACC), University of Coimbra, Coimbra, Portugal., Faculty of Medicine, Institute of Pharmacology and Experimental Therapeutics, University of Coimbra, Coimbra, Portugal. |
| authorships[2].author.id | https://openalex.org/A5001850864 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-8931-6823 |
| authorships[2].author.display_name | André Luiz Moraes Alves |
| authorships[2].countries | PT |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I76903346 |
| authorships[2].affiliations[0].raw_affiliation_string | Faculty of Medicine, Institute of Pharmacology and Experimental Therapeutics, University of Coimbra, Coimbra, Portugal. |
| authorships[2].affiliations[1].institution_ids | https://openalex.org/I76903346 |
| authorships[2].affiliations[1].raw_affiliation_string | Coimbra Institute for Clinical and Biomedical Research (iCBR) - Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal. |
| authorships[2].affiliations[2].institution_ids | https://openalex.org/I76903346 |
| authorships[2].affiliations[2].raw_affiliation_string | Faculty of Medicine, Clinical Academic Center of Coimbra (CACC), University of Coimbra, Coimbra, Portugal. |
| authorships[2].institutions[0].id | https://openalex.org/I76903346 |
| authorships[2].institutions[0].ror | https://ror.org/04z8k9a98 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I76903346 |
| authorships[2].institutions[0].country_code | PT |
| authorships[2].institutions[0].display_name | University of Coimbra |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | André Alves |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Coimbra Institute for Clinical and Biomedical Research (iCBR) - Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal., Faculty of Medicine, Clinical Academic Center of Coimbra (CACC), University of Coimbra, Coimbra, Portugal., Faculty of Medicine, Institute of Pharmacology and Experimental Therapeutics, University of Coimbra, Coimbra, Portugal. |
| authorships[3].author.id | https://openalex.org/A5005781652 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-0240-9059 |
| authorships[3].author.display_name | Sara Nunes |
| authorships[3].countries | PT |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I76903346 |
| authorships[3].affiliations[0].raw_affiliation_string | Faculty of Medicine, Clinical Academic Center of Coimbra (CACC), University of Coimbra, Coimbra, Portugal. |
| authorships[3].affiliations[1].institution_ids | https://openalex.org/I293362453, https://openalex.org/I76903346 |
| authorships[3].affiliations[1].raw_affiliation_string | Polytechnic University of Coimbra, Coimbra, Portugal. |
| authorships[3].affiliations[2].institution_ids | https://openalex.org/I293362453, https://openalex.org/I76903346 |
| authorships[3].affiliations[2].raw_affiliation_string | Coimbra Health School, H&TRC- Health and Technology Research Center, Polytechnic University of Coimbra, Coimbra, Portugal. |
| authorships[3].affiliations[3].institution_ids | https://openalex.org/I76903346 |
| authorships[3].affiliations[3].raw_affiliation_string | Coimbra Institute for Clinical and Biomedical Research (iCBR) - Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal. |
| authorships[3].affiliations[4].institution_ids | https://openalex.org/I76903346 |
| authorships[3].affiliations[4].raw_affiliation_string | Faculty of Medicine, Institute of Pharmacology and Experimental Therapeutics, University of Coimbra, Coimbra, Portugal. |
| authorships[3].institutions[0].id | https://openalex.org/I293362453 |
| authorships[3].institutions[0].ror | https://ror.org/01n8x4993 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I293362453 |
| authorships[3].institutions[0].country_code | PT |
| authorships[3].institutions[0].display_name | Polytechnic Institute of Coimbra |
| authorships[3].institutions[1].id | https://openalex.org/I76903346 |
| authorships[3].institutions[1].ror | https://ror.org/04z8k9a98 |
| authorships[3].institutions[1].type | education |
| authorships[3].institutions[1].lineage | https://openalex.org/I76903346 |
| authorships[3].institutions[1].country_code | PT |
| authorships[3].institutions[1].display_name | University of Coimbra |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Sara Nunes |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Coimbra Health School, H&TRC- Health and Technology Research Center, Polytechnic University of Coimbra, Coimbra, Portugal., Coimbra Institute for Clinical and Biomedical Research (iCBR) - Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal., Faculty of Medicine, Clinical Academic Center of Coimbra (CACC), University of Coimbra, Coimbra, Portugal., Faculty of Medicine, Institute of Pharmacology and Experimental Therapeutics, University of Coimbra, Coimbra, Portugal., Polytechnic University of Coimbra, Coimbra, Portugal. |
| authorships[4].author.id | https://openalex.org/A5034460586 |
| authorships[4].author.orcid | https://orcid.org/0000-0003-3401-9554 |
| authorships[4].author.display_name | Flávio Reis |
| authorships[4].countries | PT |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I76903346 |
| authorships[4].affiliations[0].raw_affiliation_string | Faculty of Medicine, Institute of Pharmacology and Experimental Therapeutics, University of Coimbra, Coimbra, Portugal. |
| authorships[4].affiliations[1].institution_ids | https://openalex.org/I76903346 |
| authorships[4].affiliations[1].raw_affiliation_string | Coimbra Institute for Clinical and Biomedical Research (iCBR) - Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal. |
| authorships[4].affiliations[2].institution_ids | https://openalex.org/I76903346 |
| authorships[4].affiliations[2].raw_affiliation_string | Faculty of Medicine, Clinical Academic Center of Coimbra (CACC), University of Coimbra, Coimbra, Portugal. |
| authorships[4].institutions[0].id | https://openalex.org/I76903346 |
| authorships[4].institutions[0].ror | https://ror.org/04z8k9a98 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I76903346 |
| authorships[4].institutions[0].country_code | PT |
| authorships[4].institutions[0].display_name | University of Coimbra |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Flávio Reis |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Coimbra Institute for Clinical and Biomedical Research (iCBR) - Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal., Faculty of Medicine, Clinical Academic Center of Coimbra (CACC), University of Coimbra, Coimbra, Portugal., Faculty of Medicine, Institute of Pharmacology and Experimental Therapeutics, University of Coimbra, Coimbra, Portugal. |
| authorships[5].author.id | https://openalex.org/A5088052374 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-5438-4447 |
| authorships[5].author.display_name | João O. Malva |
| authorships[5].countries | PT |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I76903346 |
| authorships[5].affiliations[0].raw_affiliation_string | Faculty of Medicine, Institute of Pharmacology and Experimental Therapeutics, University of Coimbra, Coimbra, Portugal. |
| authorships[5].affiliations[1].institution_ids | https://openalex.org/I76903346 |
| authorships[5].affiliations[1].raw_affiliation_string | Faculty of Medicine, Clinical Academic Center of Coimbra (CACC), University of Coimbra, Coimbra, Portugal. |
| authorships[5].affiliations[2].institution_ids | https://openalex.org/I76903346 |
| authorships[5].affiliations[2].raw_affiliation_string | Coimbra Institute for Clinical and Biomedical Research (iCBR) - Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal. |
| authorships[5].institutions[0].id | https://openalex.org/I76903346 |
| authorships[5].institutions[0].ror | https://ror.org/04z8k9a98 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I76903346 |
| authorships[5].institutions[0].country_code | PT |
| authorships[5].institutions[0].display_name | University of Coimbra |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | João Malva |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Coimbra Institute for Clinical and Biomedical Research (iCBR) - Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal., Faculty of Medicine, Clinical Academic Center of Coimbra (CACC), University of Coimbra, Coimbra, Portugal., Faculty of Medicine, Institute of Pharmacology and Experimental Therapeutics, University of Coimbra, Coimbra, Portugal. |
| authorships[6].author.id | https://openalex.org/A5055183619 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-1316-1319 |
| authorships[6].author.display_name | Sofia Viana |
| authorships[6].countries | PT |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I76903346 |
| authorships[6].affiliations[0].raw_affiliation_string | Faculty of Medicine, Institute of Pharmacology and Experimental Therapeutics, University of Coimbra, Coimbra, Portugal. |
| authorships[6].affiliations[1].institution_ids | https://openalex.org/I76903346 |
| authorships[6].affiliations[1].raw_affiliation_string | Coimbra Institute for Clinical and Biomedical Research (iCBR) - Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal. |
| authorships[6].affiliations[2].institution_ids | https://openalex.org/I76903346 |
| authorships[6].affiliations[2].raw_affiliation_string | Faculty of Medicine, Clinical Academic Center of Coimbra (CACC), University of Coimbra, Coimbra, Portugal. |
| authorships[6].affiliations[3].institution_ids | https://openalex.org/I293362453, https://openalex.org/I76903346 |
| authorships[6].affiliations[3].raw_affiliation_string | Polytechnic University of Coimbra, Coimbra, Portugal. |
| authorships[6].affiliations[4].institution_ids | https://openalex.org/I293362453, https://openalex.org/I76903346 |
| authorships[6].affiliations[4].raw_affiliation_string | Coimbra Health School, H&TRC- Health and Technology Research Center, Polytechnic University of Coimbra, Coimbra, Portugal. |
| authorships[6].institutions[0].id | https://openalex.org/I293362453 |
| authorships[6].institutions[0].ror | https://ror.org/01n8x4993 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I293362453 |
| authorships[6].institutions[0].country_code | PT |
| authorships[6].institutions[0].display_name | Polytechnic Institute of Coimbra |
| authorships[6].institutions[1].id | https://openalex.org/I76903346 |
| authorships[6].institutions[1].ror | https://ror.org/04z8k9a98 |
| authorships[6].institutions[1].type | education |
| authorships[6].institutions[1].lineage | https://openalex.org/I76903346 |
| authorships[6].institutions[1].country_code | PT |
| authorships[6].institutions[1].display_name | University of Coimbra |
| authorships[6].author_position | last |
| authorships[6].raw_author_name | Sofia Viana |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Coimbra Health School, H&TRC- Health and Technology Research Center, Polytechnic University of Coimbra, Coimbra, Portugal., Coimbra Institute for Clinical and Biomedical Research (iCBR) - Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal., Faculty of Medicine, Clinical Academic Center of Coimbra (CACC), University of Coimbra, Coimbra, Portugal., Faculty of Medicine, Institute of Pharmacology and Experimental Therapeutics, University of Coimbra, Coimbra, Portugal., Polytechnic University of Coimbra, Coimbra, Portugal. |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1541871/pdf |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Lipid-lowering statins and polyphenol-based supplementation: a scoping review on drug-food interaction potential |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11140 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9984999895095825 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2712 |
| primary_topic.subfield.display_name | Endocrinology, Diabetes and Metabolism |
| primary_topic.display_name | Natural Antidiabetic Agents Studies |
| related_works | https://openalex.org/W2899084033, https://openalex.org/W2748952813, https://openalex.org/W3031052312, https://openalex.org/W4389568370, https://openalex.org/W3032375762, https://openalex.org/W1995515455, https://openalex.org/W2080531066, https://openalex.org/W3108674512, https://openalex.org/W1506200166, https://openalex.org/W1489783725 |
| cited_by_count | 3 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 3 |
| locations_count | 4 |
| best_oa_location.id | doi:10.3389/fphar.2025.1541871 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S132108250 |
| best_oa_location.source.issn | 1663-9812 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1663-9812 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Frontiers in Pharmacology |
| best_oa_location.source.host_organization | https://openalex.org/P4310320527 |
| best_oa_location.source.host_organization_name | Frontiers Media |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320527 |
| best_oa_location.source.host_organization_lineage_names | Frontiers Media |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1541871/pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Frontiers in Pharmacology |
| best_oa_location.landing_page_url | https://doi.org/10.3389/fphar.2025.1541871 |
| primary_location.id | doi:10.3389/fphar.2025.1541871 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S132108250 |
| primary_location.source.issn | 1663-9812 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1663-9812 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Frontiers in Pharmacology |
| primary_location.source.host_organization | https://openalex.org/P4310320527 |
| primary_location.source.host_organization_name | Frontiers Media |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320527 |
| primary_location.source.host_organization_lineage_names | Frontiers Media |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1541871/pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Frontiers in Pharmacology |
| primary_location.landing_page_url | https://doi.org/10.3389/fphar.2025.1541871 |
| publication_date | 2025-05-30 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W2527889170, https://openalex.org/W2904575969, https://openalex.org/W3004129163, https://openalex.org/W4319786890, https://openalex.org/W4288428467, https://openalex.org/W3209657653, https://openalex.org/W2897788195, https://openalex.org/W9377672, https://openalex.org/W2045025830, https://openalex.org/W2592451892, https://openalex.org/W2896670644, https://openalex.org/W2022864291, https://openalex.org/W2213258783, https://openalex.org/W2001737389, https://openalex.org/W2796897515, https://openalex.org/W2002867712, https://openalex.org/W4392859293, https://openalex.org/W4297821733, https://openalex.org/W1778499707, https://openalex.org/W3043603449, https://openalex.org/W2020504510, https://openalex.org/W2048593300, https://openalex.org/W3034094967, https://openalex.org/W2596817964, https://openalex.org/W2613219517, https://openalex.org/W2158979706, https://openalex.org/W2968016319, https://openalex.org/W2969377001, https://openalex.org/W4389546981, https://openalex.org/W1986448104, https://openalex.org/W1969592143, https://openalex.org/W2171836350, https://openalex.org/W2942467058, https://openalex.org/W4401317918, https://openalex.org/W3004013359, https://openalex.org/W3097092944, https://openalex.org/W2128510061, https://openalex.org/W2034204587, https://openalex.org/W1984074075, https://openalex.org/W2085125553, https://openalex.org/W1701273068, https://openalex.org/W3177095491, https://openalex.org/W2785044372, https://openalex.org/W3125158701, https://openalex.org/W2030663668, https://openalex.org/W2738526018, https://openalex.org/W2062471979, https://openalex.org/W3141256924, https://openalex.org/W3126226315, https://openalex.org/W6600394677, https://openalex.org/W2110079281, https://openalex.org/W2418443305, https://openalex.org/W2038338711, https://openalex.org/W2791359882, https://openalex.org/W1933411778, https://openalex.org/W2049176537, https://openalex.org/W2079180472, https://openalex.org/W2018126221, https://openalex.org/W2034513513, https://openalex.org/W2039944972, https://openalex.org/W2025422355, https://openalex.org/W2047932628, https://openalex.org/W3195932569, https://openalex.org/W1979931282, https://openalex.org/W6887691231, https://openalex.org/W2056805087, https://openalex.org/W4283218741, https://openalex.org/W2051417300, https://openalex.org/W2093626671, https://openalex.org/W2535158955, https://openalex.org/W2079613002, https://openalex.org/W1559010782, https://openalex.org/W2325739093, https://openalex.org/W3199400878, https://openalex.org/W2800097047 |
| referenced_works_count | 75 |
| abstract_inverted_index.A | 141 |
| abstract_inverted_index.a | 63 |
| abstract_inverted_index.At | 238 |
| abstract_inverted_index.It | 277 |
| abstract_inverted_index.an | 265 |
| abstract_inverted_index.as | 11 |
| abstract_inverted_index.by | 101, 225 |
| abstract_inverted_index.in | 18, 86, 159, 168, 178, 193, 319 |
| abstract_inverted_index.is | 89 |
| abstract_inverted_index.it | 92 |
| abstract_inverted_index.of | 6, 35, 65, 104, 152, 180, 255, 300, 316 |
| abstract_inverted_index.on | 134, 233, 251, 268 |
| abstract_inverted_index.or | 227 |
| abstract_inverted_index.to | 54, 69, 82, 118, 283, 297, 311, 328 |
| abstract_inverted_index.One | 57 |
| abstract_inverted_index.The | 163, 184 |
| abstract_inverted_index.Web | 151 |
| abstract_inverted_index.and | 38, 106, 112, 124, 138, 150, 201, 221, 258, 271, 293, 322, 337 |
| abstract_inverted_index.any | 19 |
| abstract_inverted_index.are | 16, 99, 326 |
| abstract_inverted_index.for | 23, 29, 308 |
| abstract_inverted_index.has | 43 |
| abstract_inverted_index.how | 107 |
| abstract_inverted_index.key | 96 |
| abstract_inverted_index.map | 120 |
| abstract_inverted_index.may | 333 |
| abstract_inverted_index.the | 4, 12, 32, 126, 147, 169, 181, 239, 252, 269, 306, 313 |
| abstract_inverted_index.was | 144, 157, 166 |
| abstract_inverted_index.Diet | 14 |
| abstract_inverted_index.Open | 170 |
| abstract_inverted_index.Such | 324 |
| abstract_inverted_index.This | 115, 155, 262 |
| abstract_inverted_index.aims | 117 |
| abstract_inverted_index.both | 102 |
| abstract_inverted_index.core | 202 |
| abstract_inverted_index.data | 325 |
| abstract_inverted_index.drug | 218 |
| abstract_inverted_index.five | 243 |
| abstract_inverted_index.from | 286 |
| abstract_inverted_index.less | 231 |
| abstract_inverted_index.need | 307 |
| abstract_inverted_index.only | 242 |
| abstract_inverted_index.play | 190 |
| abstract_inverted_index.rate | 236 |
| abstract_inverted_index.side | 301 |
| abstract_inverted_index.such | 10 |
| abstract_inverted_index.that | 332 |
| abstract_inverted_index.they | 108 |
| abstract_inverted_index.were | 176 |
| abstract_inverted_index.with | 50, 161, 229 |
| abstract_inverted_index.work | 156, 263 |
| abstract_inverted_index.(AUC) | 220 |
| abstract_inverted_index.83.9% | 179 |
| abstract_inverted_index.These | 303 |
| abstract_inverted_index.about | 46 |
| abstract_inverted_index.alter | 83 |
| abstract_inverted_index.among | 40 |
| abstract_inverted_index.chief | 191 |
| abstract_inverted_index.class | 64 |
| abstract_inverted_index.doses | 292 |
| abstract_inverted_index.foods | 37 |
| abstract_inverted_index.known | 68 |
| abstract_inverted_index.lower | 290 |
| abstract_inverted_index.plan, | 21 |
| abstract_inverted_index.roles | 192 |
| abstract_inverted_index.study | 116 |
| abstract_inverted_index.their | 47, 132 |
| abstract_inverted_index.these | 188 |
| abstract_inverted_index.total | 217 |
| abstract_inverted_index.using | 146 |
| abstract_inverted_index.which | 95 |
| abstract_inverted_index.Still, | 73 |
| abstract_inverted_index.either | 224 |
| abstract_inverted_index.events | 296 |
| abstract_inverted_index.extent | 222 |
| abstract_inverted_index.impact | 133, 232 |
| abstract_inverted_index.level, | 241 |
| abstract_inverted_index.linked | 282 |
| abstract_inverted_index.plasma | 79 |
| abstract_inverted_index.raised | 44 |
| abstract_inverted_index.review | 143, 164, 343 |
| abstract_inverted_index.rising | 33 |
| abstract_inverted_index.shared | 100 |
| abstract_inverted_index.statin | 27, 84, 135, 205, 214, 291, 320, 335 |
| abstract_inverted_index.uptake | 196 |
| abstract_inverted_index.(Cmax), | 223 |
| abstract_inverted_index.(Tmax). | 237 |
| abstract_inverted_index.HMG-CoA | 208 |
| abstract_inverted_index.Methods | 140 |
| abstract_inverted_index.Results | 173 |
| abstract_inverted_index.Science | 153, 171 |
| abstract_inverted_index.Scopus, | 149 |
| abstract_inverted_index.action, | 206 |
| abstract_inverted_index.adverse | 55, 259, 295 |
| abstract_inverted_index.chronic | 75 |
| abstract_inverted_index.clarify | 312 |
| abstract_inverted_index.classes | 103 |
| abstract_inverted_index.develop | 329 |
| abstract_inverted_index.dietary | 8 |
| abstract_inverted_index.effects | 288 |
| abstract_inverted_index.example | 59 |
| abstract_inverted_index.healthy | 7 |
| abstract_inverted_index.leading | 53 |
| abstract_inverted_index.mediate | 109 |
| abstract_inverted_index.namely, | 207 |
| abstract_inverted_index.notable | 58 |
| abstract_inverted_index.reduced | 294 |
| abstract_inverted_index.remains | 93 |
| abstract_inverted_index.results | 250 |
| abstract_inverted_index.scoping | 142 |
| abstract_inverted_index.studies | 182, 244, 310 |
| abstract_inverted_index.support | 338 |
| abstract_inverted_index.targets | 98, 129, 186 |
| abstract_inverted_index.therapy | 28, 336 |
| abstract_inverted_index.unclear | 94 |
| abstract_inverted_index.whether | 74 |
| abstract_inverted_index.However, | 31 |
| abstract_inverted_index.achieves | 78 |
| abstract_inverted_index.adoption | 5 |
| abstract_inverted_index.altering | 216 |
| abstract_inverted_index.cellular | 195, 270 |
| abstract_inverted_index.clinical | 87, 240, 314 |
| abstract_inverted_index.concerns | 45 |
| abstract_inverted_index.designed | 158 |
| abstract_inverted_index.effects. | 56, 260, 302 |
| abstract_inverted_index.efficacy | 257 |
| abstract_inverted_index.enabling | 289 |
| abstract_inverted_index.exposure | 77, 219 |
| abstract_inverted_index.findings | 304 |
| abstract_inverted_index.identify | 125 |
| abstract_inverted_index.involves | 60 |
| abstract_inverted_index.optimize | 334 |
| abstract_inverted_index.patients | 24 |
| abstract_inverted_index.patterns | 9 |
| abstract_inverted_index.presents | 264 |
| abstract_inverted_index.protocol | 165 |
| abstract_inverted_index.reported | 121, 177 |
| abstract_inverted_index.settings | 88 |
| abstract_inverted_index.statins, | 51 |
| abstract_inverted_index.yielding | 248 |
| abstract_inverted_index.Lifestyle | 1 |
| abstract_inverted_index.Moreover, | 91 |
| abstract_inverted_index.addressed | 245 |
| abstract_inverted_index.analyzed. | 183 |
| abstract_inverted_index.conducted | 145 |
| abstract_inverted_index.consumers | 42 |
| abstract_inverted_index.efficacy, | 137 |
| abstract_inverted_index.essential | 327 |
| abstract_inverted_index.evidence, | 285 |
| abstract_inverted_index.including | 22 |
| abstract_inverted_index.influence | 70 |
| abstract_inverted_index.involved, | 130 |
| abstract_inverted_index.mediating | 187 |
| abstract_inverted_index.molecular | 272 |
| abstract_inverted_index.molecules | 105 |
| abstract_inverted_index.potential | 48, 110, 253, 298 |
| abstract_inverted_index.principal | 127 |
| abstract_inverted_index.reductase | 209 |
| abstract_inverted_index.relevance | 315 |
| abstract_inverted_index.toxicity. | 139 |
| abstract_inverted_index.treatment | 20, 340 |
| abstract_inverted_index.(MedDiet), | 15 |
| abstract_inverted_index.Background | 0 |
| abstract_inverted_index.Discussion | 261 |
| abstract_inverted_index.Framework. | 172 |
| abstract_inverted_index.Systematic | 342 |
| abstract_inverted_index.absorption | 235 |
| abstract_inverted_index.accordance | 160 |
| abstract_inverted_index.apparently | 230 |
| abstract_inverted_index.biological | 97, 128, 185 |
| abstract_inverted_index.controlled | 309 |
| abstract_inverted_index.databases. | 154 |
| abstract_inverted_index.first-line | 26 |
| abstract_inverted_index.guidelines | 331 |
| abstract_inverted_index.highlights | 278 |
| abstract_inverted_index.identifier | 345 |
| abstract_inverted_index.influenced | 213 |
| abstract_inverted_index.integrated | 266 |
| abstract_inverted_index.mechanisms | 203, 273 |
| abstract_inverted_index.metabolism | 198 |
| abstract_inverted_index.polyphenol | 61, 76 |
| abstract_inverted_index.popularity | 34 |
| abstract_inverted_index.prescribed | 25 |
| abstract_inverted_index.registered | 167 |
| abstract_inverted_index.statins’ | 71, 194, 234 |
| abstract_inverted_index.sufficient | 81 |
| abstract_inverted_index.underlying | 204, 274 |
| abstract_inverted_index.underscore | 305 |
| abstract_inverted_index.PRISMA-ScR. | 162 |
| abstract_inverted_index.Polyphenols | 211 |
| abstract_inverted_index.alterations | 318 |
| abstract_inverted_index.conflicting | 249, 284 |
| abstract_inverted_index.elucidating | 131 |
| abstract_inverted_index.enhancement | 226, 254 |
| abstract_inverted_index.esterases), | 200 |
| abstract_inverted_index.inhibition, | 228 |
| abstract_inverted_index.inhibition. | 210 |
| abstract_inverted_index.perspective | 267 |
| abstract_inverted_index.potentially | 52 |
| abstract_inverted_index.strategies. | 341 |
| abstract_inverted_index.substantial | 279 |
| abstract_inverted_index.synergistic | 287 |
| abstract_inverted_index.therapeutic | 256 |
| abstract_inverted_index.variability | 281 |
| abstract_inverted_index.controverse. | 90 |
| abstract_inverted_index.exacerbation | 299 |
| abstract_inverted_index.foundational | 17 |
| abstract_inverted_index.interactions | 49, 123, 175, 189 |
| abstract_inverted_index.particularly | 3 |
| abstract_inverted_index.registration | 344 |
| abstract_inverted_index.supplements, | 62 |
| abstract_inverted_index.Mediterranean | 13 |
| abstract_inverted_index.interactions, | 247 |
| abstract_inverted_index.interactions. | 114, 276 |
| abstract_inverted_index.significantly | 212 |
| abstract_inverted_index.concentrations | 80 |
| abstract_inverted_index.evidence-based | 330 |
| abstract_inverted_index.individualized | 339 |
| abstract_inverted_index.modifications, | 2 |
| abstract_inverted_index.nutraceuticals | 39 |
| abstract_inverted_index.phytochemicals | 67 |
| abstract_inverted_index.systematically | 119 |
| abstract_inverted_index.PubMed/Medline, | 148 |
| abstract_inverted_index.pharmacodynamic | 113 |
| abstract_inverted_index.pharmacokinetic | 111 |
| abstract_inverted_index.health-conscious | 41 |
| abstract_inverted_index.inter-individual | 280 |
| abstract_inverted_index.pharmacokinetics | 85, 321 |
| abstract_inverted_index.Statin-polyphenol | 174 |
| abstract_inverted_index.anti-dyslipidemic | 66 |
| abstract_inverted_index.pharmacodynamics. | 323 |
| abstract_inverted_index.pharmacokinetics, | 136, 215 |
| abstract_inverted_index.pharmacokinetics. | 72 |
| abstract_inverted_index.statin-polyphenol | 122, 246 |
| abstract_inverted_index.(CYP450/intestinal | 199 |
| abstract_inverted_index.MedDiet-associated | 36 |
| abstract_inverted_index.polyphenol-induced | 317 |
| abstract_inverted_index.statin–polyphenol | 275 |
| abstract_inverted_index.hypercholesterolemia. | 30 |
| abstract_inverted_index.(OATP/P-glycoprotein), | 197 |
| abstract_inverted_index.10.17605/OSF.IO/DJW5G. | 346 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 96 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 7 |
| citation_normalized_percentile.value | 0.96593999 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |