Lipids • Vol 56 • No 2
Lipidomic Analysis of Plasma from Healthy Men and Women Shows Phospholipid Class and Molecular Species Differences between Sexes
December 2020 • Annette L. West, Louise V. Michaelson, Elizabeth A. Miles, Richard P. Haslam, Karen A. Lillycrop, Ramona Georgescu, Lihua Han, Johnathan A. Napier, P…
Abstract The phospholipid composition of lipoproteins is determined by the specificity of hepatic phospholipid biosynthesis. Plasma phospholipid 20:4n‐6 and 22:6n‐3 concentrations are higher in women than in men. We used this sex difference in a lipidomics analysis of the impact of endocrine factors on the phospholipid class and molecular species composition of fasting plasma from young men and women. Diester species predominated in all lipid classes measured. 20/54 Phosphatidylcholine (PtdCho) species were alkyl …