LipidSig: a web-based tool for lipidomic data analysis Article Swipe
YOU?
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· 2021
· Open Access
·
· DOI: https://doi.org/10.1093/nar/gkab419
With the continuing rise of lipidomic studies, there is an urgent need for a useful and comprehensive tool to facilitate lipidomic data analysis. The most important features making lipids different from general metabolites are their various characteristics, including their lipid classes, double bonds, chain lengths, etc. Based on these characteristics, lipid species can be classified into different categories and, more interestingly, exert specific biological functions in a group. In an effort to simplify lipidomic analysis workflows and enhance the exploration of lipid characteristics, we have developed a highly flexible and user-friendly web server called LipidSig. It consists of five sections, namely, Profiling, Differential Expression, Correlation, Network and Machine Learning, and evaluates lipid effects on cellular or disease phenotypes. One of the specialties of LipidSig is the conversion between lipid species and characteristics according to a user-defined characteristics table. This function allows for efficient data mining for both individual lipids and subgroups of characteristics. To expand the server's practical utility, we also provide analyses focusing on fatty acid properties and multiple characteristics. In summary, LipidSig is expected to help users identify significant lipid-related features and to advance the field of lipid biology. The LipidSig webserver is freely available at http://chenglab.cmu.edu.tw/lipidsig
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/nar/gkab419
- https://academic.oup.com/nar/article-pdf/49/W1/W336/38842023/gkab419.pdf
- OA Status
- gold
- Cited By
- 68
- References
- 56
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3164948321
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3164948321Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1093/nar/gkab419Digital Object Identifier
- Title
-
LipidSig: a web-based tool for lipidomic data analysisWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-05-05Full publication date if available
- Authors
-
Wen-Jen Lin, Pei-Chun Shen, Hsiu-Cheng Liu, Yi-Chun Cho, Min-Kung Hsu, I-Chen Lin, George T.Y. Chen, Juan‐Cheng Yang, Wen‐Lung Ma, Wei‐Chung ChengList of authors in order
- Landing page
-
https://doi.org/10.1093/nar/gkab419Publisher landing page
- PDF URL
-
https://academic.oup.com/nar/article-pdf/49/W1/W336/38842023/gkab419.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://academic.oup.com/nar/article-pdf/49/W1/W336/38842023/gkab419.pdfDirect OA link when available
- Concepts
-
Lipidomics, Biology, Computational biology, Profiling (computer programming), Workflow, Web server, Table (database), Bioinformatics, Lipid metabolism, Computer science, The Internet, Data mining, World Wide Web, Biochemistry, Database, Operating systemTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
68Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 16, 2024: 18, 2023: 17, 2022: 15, 2021: 2Per-year citation counts (last 5 years)
- References (count)
-
56Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| referenced_works | https://openalex.org/W2790705492, https://openalex.org/W2120276871, https://openalex.org/W2401035952, https://openalex.org/W6687241064, https://openalex.org/W2599649240, https://openalex.org/W6685504189, https://openalex.org/W2121233961, https://openalex.org/W2990218059, https://openalex.org/W2981201899, https://openalex.org/W6771523887, https://openalex.org/W3048456013, https://openalex.org/W2161210686, https://openalex.org/W6688625267, https://openalex.org/W2522015218, https://openalex.org/W3015030919, https://openalex.org/W2767428727, https://openalex.org/W2956607536, https://openalex.org/W1985380245, https://openalex.org/W3005780203, https://openalex.org/W2550324626, https://openalex.org/W3011287221, https://openalex.org/W2104174436, https://openalex.org/W2037833102, https://openalex.org/W2742105041, https://openalex.org/W2734782517, https://openalex.org/W1993423688, https://openalex.org/W2938288400, https://openalex.org/W2767055857, https://openalex.org/W2762087180, https://openalex.org/W3087176574, https://openalex.org/W3011299576, https://openalex.org/W6767206033, https://openalex.org/W2093816724, https://openalex.org/W4242539867, https://openalex.org/W2121838954, https://openalex.org/W2944723276, https://openalex.org/W2990047251, https://openalex.org/W2086410640, https://openalex.org/W2049271632, https://openalex.org/W1976336399, https://openalex.org/W3137465236, https://openalex.org/W2767683865, https://openalex.org/W2134541386, https://openalex.org/W2991186116, https://openalex.org/W4231222727, https://openalex.org/W2921865890, https://openalex.org/W2924423411, https://openalex.org/W2151156336, https://openalex.org/W3118794296, https://openalex.org/W3143103570, https://openalex.org/W2220707375, https://openalex.org/W2189205651, https://openalex.org/W2994589269, https://openalex.org/W2967447175, https://openalex.org/W1980825418, https://openalex.org/W2173345687 |
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