Lipoplex-based RNA delivery system enhances RNAi efficiency for targeted Pest control in Spodoptera litura Article Swipe
Yun‐Heng Lu
,
Yun Liu
,
Yu‐Chun Lin
,
Yu-Jyuan Su
,
Henry David
,
Valérie Lacarrière
,
Samantha Haller
,
Yu‐Hsien Lin
,
P.K. Chiang
,
Cheng-I Hsu
,
Wei-Lun Hsu
,
Yi-Chieh Chan
,
Chen Li
,
Yueh‐Lung Wu
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.ijbiomac.2025.145091
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.ijbiomac.2025.145091
RNA interference (RNAi) represents a promising biotechnological strategy for sustainable pest control by silencing essential insect genes, resulting in increased mortality. However, its practical application remains limited due to environmental instability and delivery inefficiency of RNA molecules. In this study, three novel RNA-delivery nanoparticles-Polyplex, CS-TPP, and Lipoplex- were developed and their ability to enhance RNA stability and gene silencing efficacy against the intestinal mesh gene in Spodoptera litura was evaluated. Among them, Lipoplex showed superior performance in protecting double-stranded RNA (dsRNA) and small interfering RNA (siRNA) from degradation caused by heat, UV radiation, and RNases. In vitro cellular uptake studies using the S. litura SL1A cell line revealed significantly enhanced siRNA internalization with Lipoplex compared to other formulations. In vivo bioassays demonstrated that siRNA-loaded Lipoplex efficiently suppressed mesh expression, impaired larval development, and caused high mortality rate in early-instar larvae. Furthermore, leaf bioassay confirmed Lipoplex's potential as a stable and effective delivery platform under environmental conditions. Our findings underscore the promise of Lipoplex nanoparticles as a robust nanocarrier system for RNAi-based pest control, offering both protection and efficient intracellular delivery of RNA molecules in target insect species.
Related Topics
Concepts
Spodoptera litura
RNA interference
Spodoptera
PEST analysis
Pest control
RNA
Chemistry
Biology
Cell biology
Botany
Biochemistry
Gene
Recombinant DNA
Agronomy
Lepidoptera genitalia
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.ijbiomac.2025.145091
- OA Status
- hybrid
- Cited By
- 1
- References
- 42
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4411147077
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4411147077Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.ijbiomac.2025.145091Digital Object Identifier
- Title
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Lipoplex-based RNA delivery system enhances RNAi efficiency for targeted Pest control in Spodoptera lituraWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-06-09Full publication date if available
- Authors
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Yun‐Heng Lu, Yun Liu, Yu‐Chun Lin, Yu-Jyuan Su, Henry David, Valérie Lacarrière, Samantha Haller, Yu‐Hsien Lin, P.K. Chiang, Cheng-I Hsu, Wei-Lun Hsu, Yi-Chieh Chan, Chen Li, Yueh‐Lung WuList of authors in order
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https://doi.org/10.1016/j.ijbiomac.2025.145091Publisher landing page
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://doi.org/10.1016/j.ijbiomac.2025.145091Direct OA link when available
- Concepts
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Spodoptera litura, RNA interference, Spodoptera, PEST analysis, Pest control, RNA, Chemistry, Biology, Cell biology, Botany, Biochemistry, Gene, Recombinant DNA, Agronomy, Lepidoptera genitaliaTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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42Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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