International Journal of Biological Macromolecules • Vol 319 • No Pt 3
Lipoplex-based RNA delivery system enhances RNAi efficiency for targeted Pest control in Spodoptera litura
June 2025 • Yun‐Heng Lu, Yun Liu, Yu‐Chun Lin, Yu-Jyuan Su, Henry David, Valérie Lacarrière, Samantha Haller, Yu‐Hsien Lin, P.K. Chiang, Cheng-I Hsu, Wei-Lun Hsu…
RNA interference (RNAi) represents a promising biotechnological strategy for sustainable pest control by silencing essential insect genes, resulting in increased mortality. However, its practical application remains limited due to environmental instability and delivery inefficiency of RNA molecules. In this study, three novel RNA-delivery nanoparticles-Polyplex, CS-TPP, and Lipoplex- were developed and their ability to enhance RNA stability and gene silencing efficacy against the intestinal mesh gene in Spodoptera…