Lipopolysaccharide from Crypt-Specific Core Microbiota Modulates the Colonic Epithelial Proliferation-to-Differentiation Balance Article Swipe
Tomoaki Naito
,
Céline Mulet
,
Cristina De Castro
,
Antonio Molinaro
,
Azadeh Saffarian
,
Giulia Nigro
,
M Bérard
,
Mélanie Clerc
,
Amy B. Pedersen
,
Philippe Sansonetti
,
Thierry Pédron
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1128/mbio.01680-17
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1128/mbio.01680-17
We identified a crypt-specific core microbiota (CSCM) dominated by strictly aerobic, nonfermentative bacteria in murine cecal and proximal colonic (PC) crypts and hypothesized that, among its possible functions, it may affect epithelial regeneration. In the present work, we isolated representative CSCM strains using selective media based upon our initial 16S rRNA-based molecular identification (i.e., Acinetobacter , Delftia , and Stenotrophomonas ). Their tropism for the crypt was confirmed, and their influence on epithelial regeneration was demonstrated in vivo by monocolonization of germfree mice. We also showed that lipopolysaccharide (LPS), through its endotoxin activity, was the dominant bacterial agonist controlling proliferation. The relevant molecular mechanisms were analyzed using colonic crypt-derived organoids exposed to bacterial sonicates or highly purified LPS as agonists. We identified a Toll-like receptor 4 (TLR4)-dependent program affecting crypts at different stages of epithelial differentiation. LPS played a dual role: it repressed cell proliferation through RIPK3-mediated necroptosis of stem cells and cells of the transit-amplifying compartment and concurrently enhanced cell differentiation, particularly the goblet cell lineage. IMPORTANCE The LPS from crypt-specific core microbiota controls intestinal epithelium proliferation through necroptosis of stem cells and enhances cell differentiation, mainly the goblet cell lineage.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1128/mbio.01680-17
- OA Status
- gold
- Cited By
- 104
- References
- 63
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2765353696
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2765353696Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1128/mbio.01680-17Digital Object Identifier
- Title
-
Lipopolysaccharide from Crypt-Specific Core Microbiota Modulates the Colonic Epithelial Proliferation-to-Differentiation BalanceWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2017Year of publication
- Publication date
-
2017-10-18Full publication date if available
- Authors
-
Tomoaki Naito, Céline Mulet, Cristina De Castro, Antonio Molinaro, Azadeh Saffarian, Giulia Nigro, M Bérard, Mélanie Clerc, Amy B. Pedersen, Philippe Sansonetti, Thierry PédronList of authors in order
- Landing page
-
https://doi.org/10.1128/mbio.01680-17Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1128/mbio.01680-17Direct OA link when available
- Concepts
-
Crypt, Biology, Cell biology, Paneth cell, Stem cell, Microbiology, Lipopolysaccharide, Necroptosis, Cellular differentiation, Goblet cell, Progenitor cell, Regeneration (biology), Epithelium, Immunology, Programmed cell death, Biochemistry, Genetics, Endocrinology, Small intestine, Apoptosis, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
104Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 11, 2024: 9, 2023: 12, 2022: 16, 2021: 25Per-year citation counts (last 5 years)
- References (count)
-
63Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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