Lipopolysaccharide-induced chronic inflammation increases female serum gonadotropins and shifts the pituitary transcriptomic landscape Article Swipe
Christopher Garcia
,
Leandro M. Vélez
,
Naveena Ujagar
,
Zena Del Mundo
,
Thu Nguyen
,
Chelsea Fox
,
Adam Mark
,
Kathleen M. Fisch
,
Mark A. Lawson
,
Antoni J. Dulęba
,
Marcus Seldin
,
Dequina Nicholas
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/fendo.2023.1279878
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/fendo.2023.1279878
Introduction Female reproductive function depends on a choreographed sequence of hormonal secretion and action, where specific stresses such as inflammation exert profound disruptions. Specifically, acute LPS-induced inflammation inhibits gonadotropin production and secretion from the pituitary, thereby impacting the downstream production of sex hormones. These outcomes have only been observed in acute inflammatory stress and little is known about the mechanisms by which chronic inflammation affects reproduction. In this study we seek to understand the chronic effects of LPS on pituitary function and consequent luteinizing and follicle stimulating hormone secretion. Methods A chronic inflammatory state was induced in female mice by twice weekly injections with LPS over 6 weeks. Serum gonadotropins were measured and bulk RNAseq was performed on the pituitaries from these mice, along with basic measurements of reproductive biology. Results Surprisingly, serum luteinizing and follicle stimulating hormone was not inhibited and instead we found it was increased with repeated LPS treatments. Discussion Analysis of bulk RNA-sequencing of murine pituitary revealed paracrine activation of TGFβ pathways as a potential mechanism regulating FSH secretion in response to chronic LPS. These results provide a framework with which to begin dissecting the impacts of chronic inflammation on reproductive physiology.
Related Topics
Concepts
Inflammation
Endocrinology
Internal medicine
Luteinizing hormone
Follicle-stimulating hormone
Hormone
Paracrine signalling
Secretion
Gonadotropin
Biology
Transcriptome
Lipopolysaccharide
Medicine
Receptor
Gene expression
Gene
Biochemistry
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fendo.2023.1279878
- https://www.frontiersin.org/articles/10.3389/fendo.2023.1279878/pdf?isPublishedV2=False
- OA Status
- gold
- Cited By
- 6
- References
- 58
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4390664599
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4390664599Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fendo.2023.1279878Digital Object Identifier
- Title
-
Lipopolysaccharide-induced chronic inflammation increases female serum gonadotropins and shifts the pituitary transcriptomic landscapeWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-01-08Full publication date if available
- Authors
-
Christopher Garcia, Leandro M. Vélez, Naveena Ujagar, Zena Del Mundo, Thu Nguyen, Chelsea Fox, Adam Mark, Kathleen M. Fisch, Mark A. Lawson, Antoni J. Dulęba, Marcus Seldin, Dequina NicholasList of authors in order
- Landing page
-
https://doi.org/10.3389/fendo.2023.1279878Publisher landing page
- PDF URL
-
https://www.frontiersin.org/articles/10.3389/fendo.2023.1279878/pdf?isPublishedV2=FalseDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.frontiersin.org/articles/10.3389/fendo.2023.1279878/pdf?isPublishedV2=FalseDirect OA link when available
- Concepts
-
Inflammation, Endocrinology, Internal medicine, Luteinizing hormone, Follicle-stimulating hormone, Hormone, Paracrine signalling, Secretion, Gonadotropin, Biology, Transcriptome, Lipopolysaccharide, Medicine, Receptor, Gene expression, Gene, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
6Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 4, 2024: 2Per-year citation counts (last 5 years)
- References (count)
-
58Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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