Liquid Biopsy-Based DNA Methylation Biomarkers for Precision Medicine in Breast Cancer Article Swipe
Ieva Sadzevičienė
,
Danielius Kaubrys
,
Sonata Jarmalaitė
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1017/erm.2025.10008
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1017/erm.2025.10008
Background Current breast cancer (BC) diagnostics include detailed pathological and genetic analysis for biological subtype identification; however, throughout the course of the disease, new alterations determining the progression of the disease or resistance to treatment appear. The tests based on liquid biopsy allow minimally invasive real-time monitoring of tumour-specific alteration during the entire disease treatment. Tumour-specific genetic material fragments occur in bodily fluids, and cell-free nucleic acids are a convenient tool for analysing genetic and epigenetic changes in tumours. Evidence for the diagnostic and prognostic value of epigenetic biomarkers is gradually increasing. Although, up to date, there is limited access to in vitro diagnostic (IVD) epigenetic liquid biopsy-based tests for BC management, the data on the clinical potential of such tests and biomarkers are accumulating rapidly. Methods In this review, we focused on research involving cell-free DNA methylation biomarkers in blood serum or plasma samples from BC patients. Results Our review systematises data from genome-wide and targeted studies of DNA methylation changes in liquid biopsies from BC patients, aiming to highlight the most critical biomarkers suitable for early BC diagnosis, treatment personalisation and prognosis. Conclusion In summary, cell-free DNA methylation biomarkers show strong potential to enhance breast cancer diagnosis, prognosis, and personalised treatment through integrated clinical profiling.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1017/erm.2025.10008
- https://www.cambridge.org/core/services/aop-cambridge-core/content/view/CAB8FCEB924FE9FEAE06BA7ADE945A81/S1462399425100082a.pdf/div-class-title-liquid-biopsy-based-dna-methylation-biomarkers-for-breast-cancer-precision-medicine-div.pdf
- OA Status
- diamond
- References
- 3
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4411390636
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4411390636Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1017/erm.2025.10008Digital Object Identifier
- Title
-
Liquid Biopsy-Based DNA Methylation Biomarkers for Precision Medicine in Breast CancerWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-01-01Full publication date if available
- Authors
-
Ieva Sadzevičienė, Danielius Kaubrys, Sonata JarmalaitėList of authors in order
- Landing page
-
https://doi.org/10.1017/erm.2025.10008Publisher landing page
- PDF URL
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https://www.cambridge.org/core/services/aop-cambridge-core/content/view/CAB8FCEB924FE9FEAE06BA7ADE945A81/S1462399425100082a.pdf/div-class-title-liquid-biopsy-based-dna-methylation-biomarkers-for-breast-cancer-precision-medicine-div.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
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-
https://www.cambridge.org/core/services/aop-cambridge-core/content/view/CAB8FCEB924FE9FEAE06BA7ADE945A81/S1462399425100082a.pdf/div-class-title-liquid-biopsy-based-dna-methylation-biomarkers-for-breast-cancer-precision-medicine-div.pdfDirect OA link when available
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Breast cancer, Liquid biopsy, DNA methylation, Precision medicine, Medicine, Biopsy, DNA, Methylation, Oncology, Cancer research, Computational biology, Cancer, Internal medicine, Pathology, Biology, Genetics, Gene, Gene expressionTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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3Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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