Livogrit prevents Amiodarone-induced toxicity in experimental model of human liver (HepG2) cells and Caenorhabditis elegans by regulating redox homeostasis Article Swipe
Acharya Balkrishna
,
Vivek Gohel
,
Nishit Pathak
,
Kunal Bhattacharya
,
Rishabh Dev
,
Anurag Varshney
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1080/01480545.2024.2320189
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1080/01480545.2024.2320189
Treatment with cationic amphiphilic drugs like Amiodarone leads to development of phospholipidosis, a type of lysosomal storage disorder characterized by excessive deposition of phospholipids. Such disorder in liver enhances accumulation of drugs and its metabolites, and dysregulates lipid profiles, which subsequently leads to hepatotoxicity. In the present study, we assessed pharmacological effects of herbal medicine, Livogrit, against hepatic phospholipidosis-induced toxicity. Human liver (HepG2) cells and in vivo model of Caenorhabditis elegans (N2 and CF1553 strains) were used to study effect of Livogrit on Amiodarone-induced phospholipidosis. In HepG2 cells, Livogrit treatment displayed enhanced uptake of acidic pH-based stains and reduced phospholipid accumulation, oxidative stress, AST, ALT, cholesterol levels, and gene expression of SCD-1 and LSS. Protein levels of LPLA2 were also normalized. Livogrit treatment restored Pgp functionality which led to decreased cellular accumulation of Amiodarone as observed by UHPLC analysis. In C. elegans, Livogrit prevented ROS generation, fat-6/7 gene overexpression, and lysosomal trapping of Amiodarone in N2 strain. SOD-3::GFP expression in CF1553 strain normalized by Livogrit treatment. Livogrit regulates phospholipidosis by regulation of redox homeostasis, phospholipid anabolism, and Pgp functionality hindered by lysosomal trapping of Amiodarone. Livogrit could be a potential therapeutic intervention for amelioration of drug-induced phospholipidosis and prevent hepatotoxicity.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1080/01480545.2024.2320189
- OA Status
- green
- Cited By
- 2
- References
- 57
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4392366092
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4392366092Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1080/01480545.2024.2320189Digital Object Identifier
- Title
-
Livogrit prevents Amiodarone-induced toxicity in experimental model of human liver (HepG2) cells and Caenorhabditis elegans by regulating redox homeostasisWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
-
2024-03-01Full publication date if available
- Authors
-
Acharya Balkrishna, Vivek Gohel, Nishit Pathak, Kunal Bhattacharya, Rishabh Dev, Anurag VarshneyList of authors in order
- Landing page
-
https://doi.org/10.1080/01480545.2024.2320189Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://figshare.com/articles/journal_contribution/Livogrit_prevents_Amiodarone-induced_toxicity_in_experimental_model_of_human_liver_HepG2_cells_and_i_Caenorhabditis_elegans_i_by_regulating_redox_homeostasis/25323455Direct OA link when available
- Concepts
-
Phospholipidosis, Caenorhabditis elegans, Pharmacology, Amiodarone, Chemistry, Toxicity, Oxidative stress, Biology, Biochemistry, Phospholipid, Internal medicine, Medicine, Gene, Organic chemistry, Atrial fibrillation, MembraneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
2Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2Per-year citation counts (last 5 years)
- References (count)
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57Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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