Local genetic sex differences in quantitative traits Article Swipe
Emil Uffelmann
,
Christiaan de Leeuw
,
Marijn Schipper
,
Daniëlle Posthuma
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s41467-025-62504-4
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s41467-025-62504-4
Many traits show small global sex differences in genetic correlations and heritability. However, how these differences are distributed across the genome remains unknown. Here, we use LAVA to test for local genetic sex differences in genetic correlations, heritabilities, and the magnitude of genetic effects across 157 quantitative traits in the UK Biobank. Nearly every trait shows evidence for sex-dimorphic effects in at least one locus. We find that such loci can flag biological differences between the sexes. Moreover, we test for differences in the magnitude of genetic effects on the raw and the standardized scale. We show these have complementary interpretations, where only the latter scale is informative for heritability. Our results show how average metrics of genetic correlation and heritability across the whole genome can mask important variability between loci and that the scale of genetic effects needs to be considered carefully when comparing their magnitudes.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41467-025-62504-4
- https://www.nature.com/articles/s41467-025-62504-4.pdf
- OA Status
- gold
- Cited By
- 1
- References
- 44
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4413029144
All OpenAlex metadata
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https://openalex.org/W4413029144Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1038/s41467-025-62504-4Digital Object Identifier
- Title
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Local genetic sex differences in quantitative traitsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-08-06Full publication date if available
- Authors
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Emil Uffelmann, Christiaan de Leeuw, Marijn Schipper, Daniëlle PosthumaList of authors in order
- Landing page
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https://doi.org/10.1038/s41467-025-62504-4Publisher landing page
- PDF URL
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https://www.nature.com/articles/s41467-025-62504-4.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.nature.com/articles/s41467-025-62504-4.pdfDirect OA link when available
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Biology, Quantitative trait locus, Evolutionary biology, Genetics, Computational biology, GeneTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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