Localization and characterization of thyroid microcalcifications: A histopathological study Article Swipe
Joanne Guerlain
,
Sophie Périé
,
Marine Lefèvre
,
Joëlle Perez
,
Sophie Vandermeersch
,
Chantal Jouanneau
,
Léa Huguet
,
Vincent Frochot
,
Emmanuel Letavernier
,
Raphaël Weil
,
Stéphan Rouzière
,
Dominique Bazin
,
Michel Daudon
,
Jean‐Philippe Haymann
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pone.0224138
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pone.0224138
Thyroid calcification is frequent in thyroid nodules. The aim of our study was to evaluate the prevalence of calcifications in thyroid tissue samples of patients with various thyroid diseases, and to identify their composition according to their localization. Among 50 thyroid samples included, 56% were malignant (papillary carcinoma) and 44% were benign (adenoma, multinodular goiter, Graves' disease, sarcoidosis). Calcifications were found in 95% of samples using polarised light microscopy, whereas only 12% were described in initial pathological reports. Three types were individualised and analyzed by infrared spectrometry (μFTIR): colloid calcifications composed of calcium oxalate, capsular calcifications and psammoma bodies, both composed of calcium phosphate. Of notice, psammoma bodies characterized by FE-SEM were composed of concentric structure suggesting a slow process for crystal deposition. Calcium phosphates were found only in malignant samples whereas calcium oxalate was not associated with a define pathology. Proliferation assessed by KI67 staining was high (33% of positive follicles), and RUNX2, OPN, and CD44 positive staining were detected in thyrocytes with a broad variation between samples. However, thyrocyte proliferation and differentiation markers were not associated with the number of crystals. TRPV5 and CaSR expression was also detected in thyrocytes. mRNA transcripts expression was confirmed in a subgroup of 10 patients, altogether with other calcium transporters such as PMCA1 or Cav1.3. Interestingly, TRPV5 mRNA expression was significantly associated with number of colloid calcifications (rho = -0.72; p = 0.02). The high prevalence of calcium oxalate crystals within colloid gel raises intriguing issues upon follicle physiology for calcium and oxalate transport.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1371/journal.pone.0224138
- https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0224138&type=printable
- OA Status
- gold
- Cited By
- 28
- References
- 31
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2982111021
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2982111021Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1371/journal.pone.0224138Digital Object Identifier
- Title
-
Localization and characterization of thyroid microcalcifications: A histopathological studyWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2019Year of publication
- Publication date
-
2019-10-24Full publication date if available
- Authors
-
Joanne Guerlain, Sophie Périé, Marine Lefèvre, Joëlle Perez, Sophie Vandermeersch, Chantal Jouanneau, Léa Huguet, Vincent Frochot, Emmanuel Letavernier, Raphaël Weil, Stéphan Rouzière, Dominique Bazin, Michel Daudon, Jean‐Philippe HaymannList of authors in order
- Landing page
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https://doi.org/10.1371/journal.pone.0224138Publisher landing page
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0224138&type=printableDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0224138&type=printableDirect OA link when available
- Concepts
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Calcium oxalate, Psammoma body, Goiter, Thyroid, Calcification, Pathology, Thyroid nodules, Osteopontin, Calcium, Medicine, Thyroid carcinoma, Endocrinology, Internal medicine, Chemistry, ImmunohistochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
28Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 4, 2023: 5, 2022: 8, 2021: 6Per-year citation counts (last 5 years)
- References (count)
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31Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.structure | 115 |
| abstract_inverted_index.thyrocyte | 170 |
| abstract_inverted_index.variation | 166 |
| abstract_inverted_index.(papillary | 46 |
| abstract_inverted_index.altogether | 203 |
| abstract_inverted_index.associated | 136, 177, 219 |
| abstract_inverted_index.carcinoma) | 47 |
| abstract_inverted_index.concentric | 114 |
| abstract_inverted_index.expression | 186, 194, 216 |
| abstract_inverted_index.intriguing | 242 |
| abstract_inverted_index.pathology. | 140 |
| abstract_inverted_index.phosphate. | 103 |
| abstract_inverted_index.phosphates | 124 |
| abstract_inverted_index.physiology | 246 |
| abstract_inverted_index.prevalence | 16, 233 |
| abstract_inverted_index.suggesting | 116 |
| abstract_inverted_index.thyrocytes | 162 |
| abstract_inverted_index.transport. | 251 |
| abstract_inverted_index.composition | 33 |
| abstract_inverted_index.deposition. | 122 |
| abstract_inverted_index.follicles), | 151 |
| abstract_inverted_index.microscopy, | 68 |
| abstract_inverted_index.thyrocytes. | 191 |
| abstract_inverted_index.transcripts | 193 |
| abstract_inverted_index.multinodular | 53 |
| abstract_inverted_index.pathological | 76 |
| abstract_inverted_index.spectrometry | 86 |
| abstract_inverted_index.transporters | 207 |
| abstract_inverted_index.Proliferation | 141 |
| abstract_inverted_index.calcification | 1 |
| abstract_inverted_index.characterized | 108 |
| abstract_inverted_index.localization. | 37 |
| abstract_inverted_index.proliferation | 171 |
| abstract_inverted_index.sarcoidosis). | 57 |
| abstract_inverted_index.significantly | 218 |
| abstract_inverted_index.Calcifications | 58 |
| abstract_inverted_index.Interestingly, | 213 |
| abstract_inverted_index.calcifications | 18, 89, 95, 224 |
| abstract_inverted_index.individualised | 81 |
| abstract_inverted_index.differentiation | 173 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 91 |
| corresponding_author_ids | https://openalex.org/A5013074657, https://openalex.org/A5081337349, https://openalex.org/A5019707060, https://openalex.org/A5054800505, https://openalex.org/A5080974170, https://openalex.org/A5070090249, https://openalex.org/A5068101621, https://openalex.org/A5063089176, https://openalex.org/A5026828781, https://openalex.org/A5089104870, https://openalex.org/A5076566757, https://openalex.org/A5084448339, https://openalex.org/A5062742636, https://openalex.org/A5058702577 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 14 |
| corresponding_institution_ids | https://openalex.org/I102197404, https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I277688954, https://openalex.org/I2799857465, https://openalex.org/I39804081, https://openalex.org/I4210097159, https://openalex.org/I4210109968, https://openalex.org/I4210166768 |
| citation_normalized_percentile.value | 0.915718 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |