Long Noncoding RNA FAM201A Mediates the Radiosensitivity of Esophageal Squamous Cell Cancer by Regulating ATM and mTOR Expression via miR-101 Article Swipe
Mingqiu Chen
,
Pingping Liu
,
Yuangui Chen
,
Zhiwei Chen
,
Minmin Shen
,
Xiaohong Liu
,
Xiqing Li
,
Anchuan Li
,
Yu Lin
,
Rongqiang Yang
,
Wei Ni
,
Xin Zhou
,
Lurong Zhang
,
Ye Tian
,
Jiancheng Li
,
Junqiang Chen
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.3389/fgene.2018.00611
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.3389/fgene.2018.00611
Background: The aim of the present study was to identify the potential long non-coding (lnc.)-RNA and its associated molecular mechanisms involved in the regulation of the radiosensitivity of esophageal squamous cell cancer (ESCC) in order to assess whether it could be a biomarker for the prediction of the response to radiotherapy and prognosis in patients with ESCC. Methods: Microarrays and bioinformatics analysis were utilized to screen the potential lncRNAs associated with radiosensitivity in radiosensitive (n = 3) and radioresistant (n = 3) ESCC tumor tissues. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was performed in 35 ESCC tumor tissues (20 radiosensitive and 15 radioresistant tissues, respectively) to validate the lncRNA that contributed the most to the radiosensitivity of ESCC (named the candidate lncRNA). MTT, flow cytometry, and western blot assays were conducted to assess the effect of the candidate lncRNA on radiosensitivity in vitro in ECA109/ECA109R ESCC cells. A mouse xenograft model was established to confirm the function of the candidate lncRNA in the radiosensitivity of ESCC in vivo. The putative downstream target genes regulated by the candidate lncRNA were predicted using Starbase 2.0 software and the TargetScan database. The interactions between the candidate lncRNA and the putative downstream target genes were examined by Luciferase reporter assay, and were confirmed by PCR. Results: A total of 113 aberrantly expressed lncRNAs were identified by microarray analysis, of which family with sequence similarity 201-member A (FAM201A) was identified as the lncRNA that contributed the most to the radiosensitivity of ESCC. FAM201A was upregulated in radioresistant ESCC tumor tissues and had a poorer short-term response to radiotherapy resulting in inferior overall survival. FAM201A knockdown enhanced the radiosensitivity of ECA109/ECA109R cells by upregulating ataxia telangiectasia mutated (ATM) and mammalian target of rapamycin (mTOR) expression via the negative regulation of miR-101 expression. The mouse xenograft model demonstrated that FAM201A knockdown improved the radiosensitivity of ESCC. Conclusion: The lncRNA FAM201A, which mediated the radiosensitivity of ESCC by regulating ATM and mTOR expression via miR-101 in the present study, may be a potential biomarker for predicting radiosensitivity and patient prognosis, and may be a therapeutic target for enhancing cancer radiosensitivity in ESCC.
Related Topics
Concepts
Radioresistance
Radiosensitivity
Biology
Long non-coding RNA
Cancer research
microRNA
Microarray analysis techniques
Candidate gene
Gene
RNA
Gene expression
Cell culture
Genetics
Medicine
Radiation therapy
Internal medicine
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fgene.2018.00611
- https://www.frontiersin.org/articles/10.3389/fgene.2018.00611/pdf
- OA Status
- gold
- Cited By
- 55
- References
- 46
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2902730825
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2902730825Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fgene.2018.00611Digital Object Identifier
- Title
-
Long Noncoding RNA FAM201A Mediates the Radiosensitivity of Esophageal Squamous Cell Cancer by Regulating ATM and mTOR Expression via miR-101Work title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2018Year of publication
- Publication date
-
2018-12-05Full publication date if available
- Authors
-
Mingqiu Chen, Pingping Liu, Yuangui Chen, Zhiwei Chen, Minmin Shen, Xiaohong Liu, Xiqing Li, Anchuan Li, Yu Lin, Rongqiang Yang, Wei Ni, Xin Zhou, Lurong Zhang, Ye Tian, Jiancheng Li, Junqiang ChenList of authors in order
- Landing page
-
https://doi.org/10.3389/fgene.2018.00611Publisher landing page
- PDF URL
-
https://www.frontiersin.org/articles/10.3389/fgene.2018.00611/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.frontiersin.org/articles/10.3389/fgene.2018.00611/pdfDirect OA link when available
- Concepts
-
Radioresistance, Radiosensitivity, Biology, Long non-coding RNA, Cancer research, microRNA, Microarray analysis techniques, Candidate gene, Gene, RNA, Gene expression, Cell culture, Genetics, Medicine, Radiation therapy, Internal medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
55Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2024: 8, 2023: 6, 2022: 13, 2021: 7Per-year citation counts (last 5 years)
- References (count)
-
46Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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