Long-Term Evaluation of Patients with Neurotrophic Keratopathy Undergoing Staged Keratoplasty After Corneal Neurotization Article Swipe
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· 2024
· Open Access
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· DOI: https://doi.org/10.1080/02713683.2024.2396379
Corneal neurotization (CN) is a novel, potentially curative surgical procedure for the treatment of neurothophic keratopathy (NK). Patients with severe NK can present with corneal opacification requiring optical keratoplasty, which would likely fail without a proper trophic support of corneal nerves in the recipient cornea. This is a pilot study on 4 patients undergoing keratoplasty after CN. Pre- and postoperative data at 12, 24 months and at the last follow-up were collected for the examination of (i) best corrected visual acuity (BCVA), (ii) slit lamp examination and photograph acquisition with and without fluorescein staining, (iii) corneal aesthesiometry, (iv) in vivo confocal microscopy of the central cornea. Neurophysiological study of the corneal reflex before corneal graft and at last follow up was performed. Four female patients (47.25 ± 5.06 y.o.) underwent keratoplasty after CN (3 penetrating keratoplasty, 1 deep anterior lamellar keratoplasty). The mean interval between CN and keratoplasty was 22 (± 12) months. The mean graft survival time was 42 (± 25) months. Graft follow-up ranged from 72 to 132 months. At the final follow-up, BCVA was improved in 2 out of 4 patients. The mean corneal sensitivity was 11.9 ± 8.3 mm at last follow-up. In vivo confocal microscopy confirmed the presence of functioning nerves at the last follow-up in all patients. NK-related complications occurred in 3 eyes (2 persistent epithelial defect, 1 corneal melting). The former complication was successfully treated by autologous serum eye drops while the latter required repeated keratoplasty. Keratoplasty is a viable strategy to improve visual acuity in patients with corneal opacity who underwent CN for the treatment of NK. Even in the presence of functioning corneal nerves before keratoplasty, surgeons should be aware of the increased rate of NK-related complications that could require the need for repeated procedure.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1080/02713683.2024.2396379
- OA Status
- green
- Cited By
- 6
- References
- 21
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4402379464
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4402379464Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1080/02713683.2024.2396379Digital Object Identifier
- Title
-
Long-Term Evaluation of Patients with Neurotrophic Keratopathy Undergoing Staged Keratoplasty After Corneal NeurotizationWork title
- Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-09-08Full publication date if available
- Authors
-
Alfonso Strianese, Valentino De Ruvo, Giuseppe Giannaccare, Federico Bolognesi, Federico Biglioli, Fabiana Allevi, Filippo Tarabbia, Marco Pellegrini, Angeli Christy Yu, Niccolò Salgari, Alessandro Lozza, Luca Rossetti, Massimo Busin, Paolo FogagnoloList of authors in order
- Landing page
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https://doi.org/10.1080/02713683.2024.2396379Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://figshare.com/articles/journal_contribution/Long-Term_Evaluation_of_Patients_with_Neurotrophic_Keratopathy_Undergoing_Staged_Keratoplasty_After_Corneal_Neurotization/26968258Direct OA link when available
- Concepts
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Medicine, Ophthalmology, Corneal transplantation, Term (time), Cornea, Quantum mechanics, PhysicsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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6Total citation count in OpenAlex
- Citations by year (recent)
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2025: 6Per-year citation counts (last 5 years)
- References (count)
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21Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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