Long-term immunogenicity of BNT162b2 vaccination in the elderly and in younger health care workers Article Swipe
Pinkus Tober‐Lau
,
Tatjana Schwarz
,
Kanika Vanshylla
,
David Hillus
,
Henning Gruell
,
Norbert Suttorp
,
Irmgard Landgraf
,
Kai Kappert
,
Joachim Seybold
,
Christian Drosten
,
Florian Klein
,
Florian Kurth
,
Victor M. Corman
,
Leif Erik Sander
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1101/2021.08.26.21262468
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1101/2021.08.26.21262468
COVID-19 mRNA vaccine BNT162b2 is highly immunogenic and effective, but recent studies have indicated waning anti-SARS-CoV-2 immune responses over time. Increasing infection rates has led authorities in several countries to initiate booster campaigns for vulnerable populations, including the elderly. However, the durability of vaccine-induced immunity in the elderly is currently unknown. Here, we describe interim results of a prospective cohort study comparing immune responses in a cohort of vaccinated elderly persons to those in healthcare workers (HCW), measured six months after first immunisation with BNT162b2. Anti-SARS-CoV-2 S1-, full Spike- and RBD-IgG seropositivity rates and IgG levels at six months were significantly lower in the elderly compared to HCW. Serum neutralization of Delta VOC measured by pseudovirus neutralisation test was detectable in 43/71 (60.6%, 95%CI: 48.9-71.1) in the elderly cohort compared to 79/83 in the HCW cohort (95.2%, 95%CI: 88.3-98.1) at six months post vaccination. Consistent with the overall lower antibody levels, SARS-CoV-2-S1 T cell reactivity was reduced in the elderly compared to HCW (261.6 mIU/ml, IQR:141.5-828.6 vs 1198.0 mIU/ml, IQR: 593.9-2533.6, p<0.0001). Collectively, these findings suggest that the established two-dose vaccination regimen elicits less durable immune responses in the elderly compared to young adults. Given the recent surge in hospitalisations, even in countries with high vaccination rates such as Israel, the current data may support booster vaccinations of the elderly. Further studies to determine long-term effectiveness of COVID-19 vaccines in high-risk populations and the safety and effectiveness of additional boosters are needed.
Related Topics
Concepts
Medicine
Vaccination
Immunogenicity
Cohort
Regimen
Booster dose
Prospective cohort study
Cohort study
Immune system
Hepatitis A vaccine
Booster (rocketry)
Immunology
Internal medicine
Immunization
Astronomy
Physics
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2021.08.26.21262468
- https://www.medrxiv.org/content/medrxiv/early/2021/08/26/2021.08.26.21262468.full.pdf
- OA Status
- green
- Cited By
- 11
- References
- 6
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3194341581
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3194341581Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2021.08.26.21262468Digital Object Identifier
- Title
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Long-term immunogenicity of BNT162b2 vaccination in the elderly and in younger health care workersWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
-
2021-08-26Full publication date if available
- Authors
-
Pinkus Tober‐Lau, Tatjana Schwarz, Kanika Vanshylla, David Hillus, Henning Gruell, Norbert Suttorp, Irmgard Landgraf, Kai Kappert, Joachim Seybold, Christian Drosten, Florian Klein, Florian Kurth, Victor M. Corman, Leif Erik SanderList of authors in order
- Landing page
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https://doi.org/10.1101/2021.08.26.21262468Publisher landing page
- PDF URL
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https://www.medrxiv.org/content/medrxiv/early/2021/08/26/2021.08.26.21262468.full.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://www.medrxiv.org/content/medrxiv/early/2021/08/26/2021.08.26.21262468.full.pdfDirect OA link when available
- Concepts
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Medicine, Vaccination, Immunogenicity, Cohort, Regimen, Booster dose, Prospective cohort study, Cohort study, Immune system, Hepatitis A vaccine, Booster (rocketry), Immunology, Internal medicine, Immunization, Astronomy, PhysicsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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11Total citation count in OpenAlex
- Citations by year (recent)
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2023: 1, 2022: 5, 2021: 5Per-year citation counts (last 5 years)
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6Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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