Long-term labeling and imaging of synaptically-connected neuronal networksin vivousing double-deletion-mutant rabies viruses Article Swipe
Lei Jin
,
Heather A. Sullivan
,
Mulangma Zhu
,
Thomas K. Lavin
,
Makoto Matsuyama
,
Xin Fu
,
Nicholas E. Lea
,
Ran Xu
,
Yuanyuan Hou
,
Luca Rutigliani
,
Maxwell Pruner
,
Kelsey R. Babcock
,
Jacque Pak Kan Ip
,
Ming Hu
,
Tanya L. Daigle
,
Hongkui Zeng
,
Mriganka Sur
,
Guoping Feng
,
Ian R. Wickersham
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1101/2021.12.04.471186
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1101/2021.12.04.471186
Monosynaptic tracing is a widely-used technique for mapping neural circuitry, but its cytotoxicity has confined it primarily to anatomical applications. Here we present a second-generation system for labeling direct inputs to targeted neuronal populations with minimal toxicity, using double-deletion-mutant rabies viruses. Spread of the viruses requires expression of both deleted viral genes in trans in postsynaptic source cells; suppressing this expression with doxycycline following an initial period of viral replication reduces toxicity to postsynaptic cells. Longitudinal two-photon imaging in vivo indicated that over 90% of both presynaptic and source cells survived for the full twelve-week course of imaging. Ex vivo whole-cell recordings at 5 weeks postinfection showed that the second-generation system perturbs input and source cells much less than does the first-generation system. Finally, two-photon calcium imaging of labeled networks of visual cortex neurons showed that their visual response properties appeared normal for 10 weeks, the longest we followed them.
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- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2021.12.04.471186
- https://www.biorxiv.org/content/biorxiv/early/2021/12/04/2021.12.04.471186.full.pdf
- OA Status
- green
- Cited By
- 5
- References
- 87
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4200152443
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4200152443Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2021.12.04.471186Digital Object Identifier
- Title
-
Long-term labeling and imaging of synaptically-connected neuronal networksin vivousing double-deletion-mutant rabies virusesWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-12-04Full publication date if available
- Authors
-
Lei Jin, Heather A. Sullivan, Mulangma Zhu, Thomas K. Lavin, Makoto Matsuyama, Xin Fu, Nicholas E. Lea, Ran Xu, Yuanyuan Hou, Luca Rutigliani, Maxwell Pruner, Kelsey R. Babcock, Jacque Pak Kan Ip, Ming Hu, Tanya L. Daigle, Hongkui Zeng, Mriganka Sur, Guoping Feng, Ian R. WickershamList of authors in order
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https://doi.org/10.1101/2021.12.04.471186Publisher landing page
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https://www.biorxiv.org/content/biorxiv/early/2021/12/04/2021.12.04.471186.full.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
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https://www.biorxiv.org/content/biorxiv/early/2021/12/04/2021.12.04.471186.full.pdfDirect OA link when available
- Concepts
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Postsynaptic potential, Calcium imaging, Mutant, In vivo, Biology, Neuroscience, Ex vivo, Two-photon excitation microscopy, Cell biology, Chemistry, Gene, Calcium, Genetics, Fluorescence, Optics, Receptor, Organic chemistry, PhysicsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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5Total citation count in OpenAlex
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2024: 1, 2023: 2, 2022: 1, 2019: 1Per-year citation counts (last 5 years)
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87Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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