Long term patterns of association between MHC and helminth burdens in the bank vole support Red Queen dynamics Article Swipe
Magdalena Migalska
,
Karolina Przesmycka
,
Mohammed Alsarraf
,
Anna Bajer
,
Jolanta Behnke‐Borowczyk
,
Maciej Grzybek
,
Jerzy M. Behnke
,
Jacek Radwan
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1111/mec.16486
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1111/mec.16486
Major histocompatibility complex (MHC) genes encode proteins crucial for adaptive immunity of vertebrates. Negative frequency‐dependent selection (NFDS), resulting from adaptation of parasites to common MHC types, has been hypothesized to maintain high, functionally relevant polymorphism of MHC, but demonstration of this relationship has remained elusive. In particular, differentiation of NFDS from fluctuating selection, resulting from changes in parasite communities in time and space (FS), has proved difficult in short‐term studies. Here, we used temporal data, accumulated through long‐term monitoring of helminths infecting bank voles ( Myodes glareolus ), to test specific predictions of NFDS on MHC class II. Data were collected in three, moderately genetically differentiated subpopulations in Poland, which were characterized by some stable spatiotemporal helminth communities but also events indicating introduction of new species and loss of others. We found a complex association between individual MHC diversity and species richness, where intermediate numbers of DRB supertypes correlated with lowest species richness, but the opposite was true for DQB supertypes—arguing against universal selection for immunogenetic optimality. We also showed that particular MHC supertypes explain a portion of the variance in prevalence and abundance of helminths, but this effect was subpopulation‐specific, which is consistent with both NFDS and FS. Finally, in line with NFDS, we found that certain helminths that have recently colonized or spread in a given subpopulation, more frequently or intensely infected voles with MHC supertypes that have been common in the recent past. Overall, our results highlight complex spatial and temporal patterns of MHC‐parasite associations, the latter being consistent with Red Queen coevolutionary dynamics.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/mec.16486
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/mec.16486
- OA Status
- bronze
- Cited By
- 20
- References
- 72
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4229051572
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4229051572Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1111/mec.16486Digital Object Identifier
- Title
-
Long term patterns of association between MHC and helminth burdens in the bank vole support Red Queen dynamicsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-05-05Full publication date if available
- Authors
-
Magdalena Migalska, Karolina Przesmycka, Mohammed Alsarraf, Anna Bajer, Jolanta Behnke‐Borowczyk, Maciej Grzybek, Jerzy M. Behnke, Jacek RadwanList of authors in order
- Landing page
-
https://doi.org/10.1111/mec.16486Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/mec.16486Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/mec.16486Direct OA link when available
- Concepts
-
Biology, Major histocompatibility complex, Species richness, Evolutionary biology, Zoology, Helminths, Ecology, Immunology, Immune systemTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
20Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 6, 2024: 9, 2023: 3, 2022: 2Per-year citation counts (last 5 years)
- References (count)
-
72Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4229051572 |
|---|---|
| doi | https://doi.org/10.1111/mec.16486 |
| ids.doi | https://doi.org/10.1111/mec.16486 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/35510766 |
| ids.openalex | https://openalex.org/W4229051572 |
| fwci | 5.09680397 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D000818 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Animals |
| mesh[1].qualifier_ui | Q000235 |
| mesh[1].descriptor_ui | D003411 |
| mesh[1].is_major_topic | True |
| mesh[1].qualifier_name | genetics |
| mesh[1].descriptor_name | Arvicolinae |
| mesh[2].qualifier_ui | Q000235 |
| mesh[2].descriptor_ui | D006376 |
| mesh[2].is_major_topic | True |
| mesh[2].qualifier_name | genetics |
| mesh[2].descriptor_name | Helminths |
| mesh[3].qualifier_ui | Q000235 |
| mesh[3].descriptor_ui | D000949 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | genetics |
| mesh[3].descriptor_name | Histocompatibility Antigens Class II |
| mesh[4].qualifier_ui | |
| mesh[4].descriptor_ui | D011044 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | |
| mesh[4].descriptor_name | Poland |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D011110 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Polymorphism, Genetic |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D012641 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | Selection, Genetic |
| mesh[7].qualifier_ui | |
| mesh[7].descriptor_ui | D000818 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | |
| mesh[7].descriptor_name | Animals |
| mesh[8].qualifier_ui | Q000235 |
| mesh[8].descriptor_ui | D003411 |
| mesh[8].is_major_topic | True |
| mesh[8].qualifier_name | genetics |
| mesh[8].descriptor_name | Arvicolinae |
| mesh[9].qualifier_ui | Q000235 |
| mesh[9].descriptor_ui | D006376 |
| mesh[9].is_major_topic | True |
| mesh[9].qualifier_name | genetics |
| mesh[9].descriptor_name | Helminths |
| mesh[10].qualifier_ui | Q000235 |
| mesh[10].descriptor_ui | D000949 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | genetics |
| mesh[10].descriptor_name | Histocompatibility Antigens Class II |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D011044 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Poland |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D011110 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | Polymorphism, Genetic |
| mesh[13].qualifier_ui | |
| mesh[13].descriptor_ui | D012641 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | |
| mesh[13].descriptor_name | Selection, Genetic |
| type | article |
| title | Long term patterns of association between MHC and helminth burdens in the bank vole support Red Queen dynamics |
| biblio.issue | 12 |
| biblio.volume | 31 |
| biblio.last_page | 3415 |
| biblio.first_page | 3400 |
| topics[0].id | https://openalex.org/T11764 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9991999864578247 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1311 |
| topics[0].subfield.display_name | Genetics |
| topics[0].display_name | Evolution and Genetic Dynamics |
| topics[1].id | https://openalex.org/T11913 |
| topics[1].field.id | https://openalex.org/fields/23 |
| topics[1].field.display_name | Environmental Science |
| topics[1].score | 0.9962000250816345 |
| topics[1].domain.id | https://openalex.org/domains/3 |
| topics[1].domain.display_name | Physical Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2303 |
| topics[1].subfield.display_name | Ecology |
| topics[1].display_name | Animal Ecology and Behavior Studies |
| topics[2].id | https://openalex.org/T10174 |
| topics[2].field.id | https://openalex.org/fields/11 |
| topics[2].field.display_name | Agricultural and Biological Sciences |
| topics[2].score | 0.995199978351593 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1105 |
| topics[2].subfield.display_name | Ecology, Evolution, Behavior and Systematics |
| topics[2].display_name | Animal Behavior and Reproduction |
| is_xpac | False |
| apc_list.value | 4940 |
| apc_list.currency | USD |
| apc_list.value_usd | 4940 |
| apc_paid | |
| concepts[0].id | https://openalex.org/C86803240 |
| concepts[0].level | 0 |
| concepts[0].score | 0.9011021852493286 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[0].display_name | Biology |
| concepts[1].id | https://openalex.org/C207936829 |
| concepts[1].level | 3 |
| concepts[1].score | 0.7055045366287231 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q423163 |
| concepts[1].display_name | Major histocompatibility complex |
| concepts[2].id | https://openalex.org/C53565203 |
| concepts[2].level | 2 |
| concepts[2].score | 0.5630722641944885 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q17146659 |
| concepts[2].display_name | Species richness |
| concepts[3].id | https://openalex.org/C78458016 |
| concepts[3].level | 1 |
| concepts[3].score | 0.5480161905288696 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q840400 |
| concepts[3].display_name | Evolutionary biology |
| concepts[4].id | https://openalex.org/C90856448 |
| concepts[4].level | 1 |
| concepts[4].score | 0.42586031556129456 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q431 |
| concepts[4].display_name | Zoology |
| concepts[5].id | https://openalex.org/C165901193 |
| concepts[5].level | 2 |
| concepts[5].score | 0.41265544295310974 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q3129936 |
| concepts[5].display_name | Helminths |
| concepts[6].id | https://openalex.org/C18903297 |
| concepts[6].level | 1 |
| concepts[6].score | 0.4014620780944824 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q7150 |
| concepts[6].display_name | Ecology |
| concepts[7].id | https://openalex.org/C203014093 |
| concepts[7].level | 1 |
| concepts[7].score | 0.24565449357032776 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q101929 |
| concepts[7].display_name | Immunology |
| concepts[8].id | https://openalex.org/C8891405 |
| concepts[8].level | 2 |
| concepts[8].score | 0.17641383409500122 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q1059 |
| concepts[8].display_name | Immune system |
| keywords[0].id | https://openalex.org/keywords/biology |
| keywords[0].score | 0.9011021852493286 |
| keywords[0].display_name | Biology |
| keywords[1].id | https://openalex.org/keywords/major-histocompatibility-complex |
| keywords[1].score | 0.7055045366287231 |
| keywords[1].display_name | Major histocompatibility complex |
| keywords[2].id | https://openalex.org/keywords/species-richness |
| keywords[2].score | 0.5630722641944885 |
| keywords[2].display_name | Species richness |
| keywords[3].id | https://openalex.org/keywords/evolutionary-biology |
| keywords[3].score | 0.5480161905288696 |
| keywords[3].display_name | Evolutionary biology |
| keywords[4].id | https://openalex.org/keywords/zoology |
| keywords[4].score | 0.42586031556129456 |
| keywords[4].display_name | Zoology |
| keywords[5].id | https://openalex.org/keywords/helminths |
| keywords[5].score | 0.41265544295310974 |
| keywords[5].display_name | Helminths |
| keywords[6].id | https://openalex.org/keywords/ecology |
| keywords[6].score | 0.4014620780944824 |
| keywords[6].display_name | Ecology |
| keywords[7].id | https://openalex.org/keywords/immunology |
| keywords[7].score | 0.24565449357032776 |
| keywords[7].display_name | Immunology |
| keywords[8].id | https://openalex.org/keywords/immune-system |
| keywords[8].score | 0.17641383409500122 |
| keywords[8].display_name | Immune system |
| language | en |
| locations[0].id | doi:10.1111/mec.16486 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S22454499 |
| locations[0].source.issn | 0962-1083, 1365-294X |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 0962-1083 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Molecular Ecology |
| locations[0].source.host_organization | https://openalex.org/P4310320595 |
| locations[0].source.host_organization_name | Wiley |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320595 |
| locations[0].license | |
| locations[0].pdf_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/mec.16486 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Molecular Ecology |
| locations[0].landing_page_url | https://doi.org/10.1111/mec.16486 |
| locations[1].id | pmid:35510766 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Molecular ecology |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/35510766 |
| locations[2].id | pmh:oai:ruj.uj.edu.pl:item/307377 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306400316 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | Homo Politicus (Academy of Humanities and Economics in Lodz) |
| locations[2].source.host_organization | |
| locations[2].source.host_organization_name | |
| locations[2].source.host_organization_lineage | |
| locations[2].license | cc-by-nc-nd |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | info:eu-repo/semantics/article |
| locations[2].license_id | https://openalex.org/licenses/cc-by-nc-nd |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | |
| locations[2].landing_page_url | https://ruj.uj.edu.pl/xmlui/handle/item/307377 |
| locations[3].id | pmh:oai:pubmedcentral.nih.gov:9325469 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S2764455111 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | PubMed Central |
| locations[3].source.host_organization | https://openalex.org/I1299303238 |
| locations[3].source.host_organization_name | National Institutes of Health |
| locations[3].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[3].license | other-oa |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | https://openalex.org/licenses/other-oa |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Mol Ecol |
| locations[3].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/9325469 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5036777013 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-0144-4370 |
| authorships[0].author.display_name | Magdalena Migalska |
| authorships[0].countries | PL |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I126596746 |
| authorships[0].affiliations[0].raw_affiliation_string | Institute of Environmental Sciences, Faculty of Biology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland |
| authorships[0].institutions[0].id | https://openalex.org/I126596746 |
| authorships[0].institutions[0].ror | https://ror.org/03bqmcz70 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I126596746 |
| authorships[0].institutions[0].country_code | PL |
| authorships[0].institutions[0].display_name | Jagiellonian University |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Magdalena Migalska |
| authorships[0].is_corresponding | True |
| authorships[0].raw_affiliation_strings | Institute of Environmental Sciences, Faculty of Biology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland |
| authorships[1].author.id | https://openalex.org/A5020536927 |
| authorships[1].author.orcid | https://orcid.org/0000-0001-8952-5361 |
| authorships[1].author.display_name | Karolina Przesmycka |
| authorships[1].countries | PL |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I59411706 |
| authorships[1].affiliations[0].raw_affiliation_string | Institute of Environmental Biology Faculty of Biology Adam Mickiewicz University Poznań Poland |
| authorships[1].institutions[0].id | https://openalex.org/I59411706 |
| authorships[1].institutions[0].ror | https://ror.org/04g6bbq64 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I59411706 |
| authorships[1].institutions[0].country_code | PL |
| authorships[1].institutions[0].display_name | Adam Mickiewicz University in Poznań |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Karolina Przesmycka |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Institute of Environmental Biology Faculty of Biology Adam Mickiewicz University Poznań Poland |
| authorships[2].author.id | https://openalex.org/A5084832614 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-6330-0719 |
| authorships[2].author.display_name | Mohammed Alsarraf |
| authorships[2].countries | PL |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I4654613 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Eco-epidemiology of Parasitic Diseases, Institute of Developmental Biology and Biomedical Sciences, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warsaw, Poland |
| authorships[2].institutions[0].id | https://openalex.org/I4654613 |
| authorships[2].institutions[0].ror | https://ror.org/039bjqg32 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I4654613 |
| authorships[2].institutions[0].country_code | PL |
| authorships[2].institutions[0].display_name | University of Warsaw |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Mohammed Alsarraf |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Eco-epidemiology of Parasitic Diseases, Institute of Developmental Biology and Biomedical Sciences, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warsaw, Poland |
| authorships[3].author.id | https://openalex.org/A5002998518 |
| authorships[3].author.orcid | https://orcid.org/0000-0001-6199-8458 |
| authorships[3].author.display_name | Anna Bajer |
| authorships[3].countries | PL |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I4654613 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Eco-epidemiology of Parasitic Diseases, Institute of Developmental Biology and Biomedical Sciences, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warsaw, Poland |
| authorships[3].institutions[0].id | https://openalex.org/I4654613 |
| authorships[3].institutions[0].ror | https://ror.org/039bjqg32 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I4654613 |
| authorships[3].institutions[0].country_code | PL |
| authorships[3].institutions[0].display_name | University of Warsaw |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Anna Bajer |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Eco-epidemiology of Parasitic Diseases, Institute of Developmental Biology and Biomedical Sciences, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warsaw, Poland |
| authorships[4].author.id | https://openalex.org/A5089230390 |
| authorships[4].author.orcid | https://orcid.org/0000-0003-2085-038X |
| authorships[4].author.display_name | Jolanta Behnke‐Borowczyk |
| authorships[4].countries | PL |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I55783418 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Forest Entomology and Pathology Faculty of Forestry and Wood Technology Poznań University of Life Sciences Poznań Poland |
| authorships[4].institutions[0].id | https://openalex.org/I55783418 |
| authorships[4].institutions[0].ror | https://ror.org/03tth1e03 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I55783418 |
| authorships[4].institutions[0].country_code | PL |
| authorships[4].institutions[0].display_name | University of Life Sciences in Poznań |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Jolanta Behnke‐Borowczyk |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Forest Entomology and Pathology Faculty of Forestry and Wood Technology Poznań University of Life Sciences Poznań Poland |
| authorships[5].author.id | https://openalex.org/A5071788972 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-8780-0304 |
| authorships[5].author.display_name | Maciej Grzybek |
| authorships[5].countries | PL |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I75124487 |
| authorships[5].affiliations[0].raw_affiliation_string | Institute of Maritime and Tropical Medicine, Medical University of Gdansk, Powstania Styczniowego 9B, 81-429 Gdynia, Poland |
| authorships[5].institutions[0].id | https://openalex.org/I75124487 |
| authorships[5].institutions[0].ror | https://ror.org/019sbgd69 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I75124487 |
| authorships[5].institutions[0].country_code | PL |
| authorships[5].institutions[0].display_name | Gdańsk Medical University |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Maciej Grzybek |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Institute of Maritime and Tropical Medicine, Medical University of Gdansk, Powstania Styczniowego 9B, 81-429 Gdynia, Poland |
| authorships[6].author.id | https://openalex.org/A5054422592 |
| authorships[6].author.orcid | https://orcid.org/0000-0001-9396-2572 |
| authorships[6].author.display_name | Jerzy M. Behnke |
| authorships[6].countries | GB |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I142263535 |
| authorships[6].affiliations[0].raw_affiliation_string | School of Life Science, University of Nottingham, University Park, Nottingham, NG7 2RD UK |
| authorships[6].institutions[0].id | https://openalex.org/I142263535 |
| authorships[6].institutions[0].ror | https://ror.org/01ee9ar58 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I142263535 |
| authorships[6].institutions[0].country_code | GB |
| authorships[6].institutions[0].display_name | University of Nottingham |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Jerzy M. Behnke |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | School of Life Science, University of Nottingham, University Park, Nottingham, NG7 2RD UK |
| authorships[7].author.id | https://openalex.org/A5072722511 |
| authorships[7].author.orcid | https://orcid.org/0000-0001-8503-5701 |
| authorships[7].author.display_name | Jacek Radwan |
| authorships[7].countries | PL |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I59411706 |
| authorships[7].affiliations[0].raw_affiliation_string | Institute of Environmental Biology Faculty of Biology Adam Mickiewicz University Poznań Poland |
| authorships[7].institutions[0].id | https://openalex.org/I59411706 |
| authorships[7].institutions[0].ror | https://ror.org/04g6bbq64 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I59411706 |
| authorships[7].institutions[0].country_code | PL |
| authorships[7].institutions[0].display_name | Adam Mickiewicz University in Poznań |
| authorships[7].author_position | last |
| authorships[7].raw_author_name | Jacek Radwan |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Institute of Environmental Biology Faculty of Biology Adam Mickiewicz University Poznań Poland |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/mec.16486 |
| open_access.oa_status | bronze |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Long term patterns of association between MHC and helminth burdens in the bank vole support Red Queen dynamics |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11764 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9991999864578247 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1311 |
| primary_topic.subfield.display_name | Genetics |
| primary_topic.display_name | Evolution and Genetic Dynamics |
| related_works | https://openalex.org/W2022250864, https://openalex.org/W4385061579, https://openalex.org/W1855418621, https://openalex.org/W1968126718, https://openalex.org/W195123958, https://openalex.org/W2055126334, https://openalex.org/W1989076499, https://openalex.org/W1965845667, https://openalex.org/W2149519193, https://openalex.org/W2159663706 |
| cited_by_count | 20 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 6 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 9 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 3 |
| counts_by_year[3].year | 2022 |
| counts_by_year[3].cited_by_count | 2 |
| locations_count | 4 |
| best_oa_location.id | doi:10.1111/mec.16486 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S22454499 |
| best_oa_location.source.issn | 0962-1083, 1365-294X |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | 0962-1083 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Molecular Ecology |
| best_oa_location.source.host_organization | https://openalex.org/P4310320595 |
| best_oa_location.source.host_organization_name | Wiley |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320595 |
| best_oa_location.license | |
| best_oa_location.pdf_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/mec.16486 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Molecular Ecology |
| best_oa_location.landing_page_url | https://doi.org/10.1111/mec.16486 |
| primary_location.id | doi:10.1111/mec.16486 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S22454499 |
| primary_location.source.issn | 0962-1083, 1365-294X |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 0962-1083 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Molecular Ecology |
| primary_location.source.host_organization | https://openalex.org/P4310320595 |
| primary_location.source.host_organization_name | Wiley |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320595 |
| primary_location.license | |
| primary_location.pdf_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/mec.16486 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Molecular Ecology |
| primary_location.landing_page_url | https://doi.org/10.1111/mec.16486 |
| publication_date | 2022-05-05 |
| publication_year | 2022 |
| referenced_works | https://openalex.org/W2915009965, https://openalex.org/W2620939786, https://openalex.org/W2982162177, https://openalex.org/W2008183857, https://openalex.org/W2076856960, https://openalex.org/W1973974708, https://openalex.org/W2132649740, https://openalex.org/W2946703407, https://openalex.org/W2806773519, https://openalex.org/W2018855162, https://openalex.org/W2618142589, https://openalex.org/W2080956086, https://openalex.org/W2164003162, https://openalex.org/W2096472399, https://openalex.org/W2068020601, https://openalex.org/W2123914644, https://openalex.org/W2129979981, https://openalex.org/W816808373, https://openalex.org/W2269132714, https://openalex.org/W4206216939, https://openalex.org/W2056384440, https://openalex.org/W2107144321, https://openalex.org/W1972657145, https://openalex.org/W2141629782, https://openalex.org/W2108134955, https://openalex.org/W2478024437, https://openalex.org/W2608171249, https://openalex.org/W2915696306, https://openalex.org/W2002587842, https://openalex.org/W2080511971, https://openalex.org/W1990719254, https://openalex.org/W2108328346, https://openalex.org/W2006337677, https://openalex.org/W2550992535, https://openalex.org/W3126998181, https://openalex.org/W2157764447, https://openalex.org/W2783693153, https://openalex.org/W2582743722, https://openalex.org/W3004537277, https://openalex.org/W2105554851, https://openalex.org/W2253414912, https://openalex.org/W2161293512, https://openalex.org/W2130783116, https://openalex.org/W2122003337, https://openalex.org/W4319587689, https://openalex.org/W2164180019, https://openalex.org/W2037980775, https://openalex.org/W2170293083, https://openalex.org/W2560656592, https://openalex.org/W2074954918, https://openalex.org/W2127366570, https://openalex.org/W1972153212, https://openalex.org/W2002744925, https://openalex.org/W2147397610, https://openalex.org/W2032301833, https://openalex.org/W2007963685, https://openalex.org/W4206977389, https://openalex.org/W2077861902, https://openalex.org/W2063866314, https://openalex.org/W2156141960, https://openalex.org/W1769860648, https://openalex.org/W1584565635, https://openalex.org/W2058458983, https://openalex.org/W2122574219, https://openalex.org/W1995059907, https://openalex.org/W4229051572, https://openalex.org/W2099801222, https://openalex.org/W2063654577, https://openalex.org/W2534161007, https://openalex.org/W2047417387, https://openalex.org/W2086013059, https://openalex.org/W2136793595 |
| referenced_works_count | 72 |
| abstract_inverted_index.( | 85 |
| abstract_inverted_index.a | 133, 176, 217 |
| abstract_inverted_index.), | 88 |
| abstract_inverted_index.In | 46 |
| abstract_inverted_index.We | 131, 168 |
| abstract_inverted_index.by | 113 |
| abstract_inverted_index.in | 57, 60, 68, 102, 108, 181, 201, 216, 233 |
| abstract_inverted_index.is | 193 |
| abstract_inverted_index.of | 12, 21, 36, 40, 49, 80, 93, 124, 129, 146, 178, 185, 246 |
| abstract_inverted_index.on | 95 |
| abstract_inverted_index.or | 214, 222 |
| abstract_inverted_index.to | 23, 30, 89 |
| abstract_inverted_index.we | 72, 205 |
| abstract_inverted_index.DQB | 160 |
| abstract_inverted_index.DRB | 147 |
| abstract_inverted_index.FS. | 199 |
| abstract_inverted_index.II. | 98 |
| abstract_inverted_index.MHC | 25, 96, 138, 173, 227 |
| abstract_inverted_index.Red | 254 |
| abstract_inverted_index.and | 62, 127, 140, 183, 198, 243 |
| abstract_inverted_index.but | 38, 119, 154, 187 |
| abstract_inverted_index.for | 9, 159, 165 |
| abstract_inverted_index.has | 27, 43, 65 |
| abstract_inverted_index.new | 125 |
| abstract_inverted_index.our | 238 |
| abstract_inverted_index.the | 155, 179, 234, 249 |
| abstract_inverted_index.was | 157, 190 |
| abstract_inverted_index.Data | 99 |
| abstract_inverted_index.MHC, | 37 |
| abstract_inverted_index.NFDS | 50, 94, 197 |
| abstract_inverted_index.also | 120, 169 |
| abstract_inverted_index.bank | 83 |
| abstract_inverted_index.been | 28, 231 |
| abstract_inverted_index.both | 196 |
| abstract_inverted_index.from | 19, 51, 55 |
| abstract_inverted_index.have | 211, 230 |
| abstract_inverted_index.line | 202 |
| abstract_inverted_index.loss | 128 |
| abstract_inverted_index.more | 220 |
| abstract_inverted_index.some | 114 |
| abstract_inverted_index.test | 90 |
| abstract_inverted_index.that | 171, 207, 210, 229 |
| abstract_inverted_index.this | 41, 188 |
| abstract_inverted_index.time | 61 |
| abstract_inverted_index.true | 158 |
| abstract_inverted_index.used | 73 |
| abstract_inverted_index.were | 100, 111 |
| abstract_inverted_index.with | 150, 195, 203, 226, 253 |
| abstract_inverted_index.(FS), | 64 |
| abstract_inverted_index.(MHC) | 4 |
| abstract_inverted_index.Here, | 71 |
| abstract_inverted_index.Major | 1 |
| abstract_inverted_index.NFDS, | 204 |
| abstract_inverted_index.Queen | 255 |
| abstract_inverted_index.being | 251 |
| abstract_inverted_index.class | 97 |
| abstract_inverted_index.data, | 75 |
| abstract_inverted_index.found | 132, 206 |
| abstract_inverted_index.genes | 5 |
| abstract_inverted_index.given | 218 |
| abstract_inverted_index.high, | 32 |
| abstract_inverted_index.past. | 236 |
| abstract_inverted_index.space | 63 |
| abstract_inverted_index.voles | 84, 225 |
| abstract_inverted_index.where | 143 |
| abstract_inverted_index.which | 110, 192 |
| abstract_inverted_index.Myodes | 86 |
| abstract_inverted_index.common | 24, 232 |
| abstract_inverted_index.effect | 189 |
| abstract_inverted_index.encode | 6 |
| abstract_inverted_index.events | 121 |
| abstract_inverted_index.latter | 250 |
| abstract_inverted_index.lowest | 151 |
| abstract_inverted_index.proved | 66 |
| abstract_inverted_index.recent | 235 |
| abstract_inverted_index.showed | 170 |
| abstract_inverted_index.spread | 215 |
| abstract_inverted_index.stable | 115 |
| abstract_inverted_index.three, | 103 |
| abstract_inverted_index.types, | 26 |
| abstract_inverted_index.(NFDS), | 17 |
| abstract_inverted_index.Poland, | 109 |
| abstract_inverted_index.against | 162 |
| abstract_inverted_index.between | 136 |
| abstract_inverted_index.certain | 208 |
| abstract_inverted_index.changes | 56 |
| abstract_inverted_index.complex | 3, 134, 241 |
| abstract_inverted_index.crucial | 8 |
| abstract_inverted_index.explain | 175 |
| abstract_inverted_index.numbers | 145 |
| abstract_inverted_index.others. | 130 |
| abstract_inverted_index.portion | 177 |
| abstract_inverted_index.results | 239 |
| abstract_inverted_index.spatial | 242 |
| abstract_inverted_index.species | 126, 141, 152 |
| abstract_inverted_index.through | 77 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.Finally, | 200 |
| abstract_inverted_index.Negative | 14 |
| abstract_inverted_index.Overall, | 237 |
| abstract_inverted_index.adaptive | 10 |
| abstract_inverted_index.elusive. | 45 |
| abstract_inverted_index.helminth | 117 |
| abstract_inverted_index.immunity | 11 |
| abstract_inverted_index.infected | 224 |
| abstract_inverted_index.maintain | 31 |
| abstract_inverted_index.opposite | 156 |
| abstract_inverted_index.parasite | 58 |
| abstract_inverted_index.patterns | 245 |
| abstract_inverted_index.proteins | 7 |
| abstract_inverted_index.recently | 212 |
| abstract_inverted_index.relevant | 34 |
| abstract_inverted_index.remained | 44 |
| abstract_inverted_index.specific | 91 |
| abstract_inverted_index.studies. | 70 |
| abstract_inverted_index.temporal | 74, 244 |
| abstract_inverted_index.variance | 180 |
| abstract_inverted_index.abundance | 184 |
| abstract_inverted_index.collected | 101 |
| abstract_inverted_index.colonized | 213 |
| abstract_inverted_index.difficult | 67 |
| abstract_inverted_index.diversity | 139 |
| abstract_inverted_index.dynamics. | 257 |
| abstract_inverted_index.glareolus | 87 |
| abstract_inverted_index.helminths | 81, 209 |
| abstract_inverted_index.highlight | 240 |
| abstract_inverted_index.infecting | 82 |
| abstract_inverted_index.intensely | 223 |
| abstract_inverted_index.parasites | 22 |
| abstract_inverted_index.resulting | 18, 54 |
| abstract_inverted_index.richness, | 142, 153 |
| abstract_inverted_index.selection | 16, 164 |
| abstract_inverted_index.universal | 163 |
| abstract_inverted_index.adaptation | 20 |
| abstract_inverted_index.consistent | 194, 252 |
| abstract_inverted_index.correlated | 149 |
| abstract_inverted_index.frequently | 221 |
| abstract_inverted_index.helminths, | 186 |
| abstract_inverted_index.indicating | 122 |
| abstract_inverted_index.individual | 137 |
| abstract_inverted_index.moderately | 104 |
| abstract_inverted_index.monitoring | 79 |
| abstract_inverted_index.particular | 172 |
| abstract_inverted_index.prevalence | 182 |
| abstract_inverted_index.selection, | 53 |
| abstract_inverted_index.supertypes | 148, 174, 228 |
| abstract_inverted_index.accumulated | 76 |
| abstract_inverted_index.association | 135 |
| abstract_inverted_index.communities | 59, 118 |
| abstract_inverted_index.fluctuating | 52 |
| abstract_inverted_index.genetically | 105 |
| abstract_inverted_index.long‐term | 78 |
| abstract_inverted_index.optimality. | 167 |
| abstract_inverted_index.particular, | 47 |
| abstract_inverted_index.predictions | 92 |
| abstract_inverted_index.functionally | 33 |
| abstract_inverted_index.hypothesized | 29 |
| abstract_inverted_index.intermediate | 144 |
| abstract_inverted_index.introduction | 123 |
| abstract_inverted_index.polymorphism | 35 |
| abstract_inverted_index.relationship | 42 |
| abstract_inverted_index.short‐term | 69 |
| abstract_inverted_index.vertebrates. | 13 |
| abstract_inverted_index.associations, | 248 |
| abstract_inverted_index.characterized | 112 |
| abstract_inverted_index.demonstration | 39 |
| abstract_inverted_index.immunogenetic | 166 |
| abstract_inverted_index.MHC‐parasite | 247 |
| abstract_inverted_index.coevolutionary | 256 |
| abstract_inverted_index.differentiated | 106 |
| abstract_inverted_index.spatiotemporal | 116 |
| abstract_inverted_index.subpopulation, | 219 |
| abstract_inverted_index.subpopulations | 107 |
| abstract_inverted_index.differentiation | 48 |
| abstract_inverted_index.histocompatibility | 2 |
| abstract_inverted_index.supertypes—arguing | 161 |
| abstract_inverted_index.frequency‐dependent | 15 |
| abstract_inverted_index.subpopulation‐specific, | 191 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 94 |
| corresponding_author_ids | https://openalex.org/A5036777013 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 8 |
| corresponding_institution_ids | https://openalex.org/I126596746 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/15 |
| sustainable_development_goals[0].score | 0.6800000071525574 |
| sustainable_development_goals[0].display_name | Life in Land |
| citation_normalized_percentile.value | 0.93801604 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |