Long-Term Preclinical Evaluation of a Permanent Stent Developed for the Human Eustachian Tube Article Swipe
Katharina Schmitt
,
Malena Timm
,
Philipp Krüger
,
Niels Oppel
,
Alexandra Napp
,
Friederike Pohl
,
Robert Schuon
,
Andreas Kampmann
,
Lisa Kötter
,
Marion Bankstahl
,
Thomas Lenarz
,
Tobias Stein
,
Gerrit Paasche
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/bioengineering11080755
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/bioengineering11080755
The Eustachian tube (ET) is a bottleneck when it comes to middle ear (ME) health. If its function is impaired, this can lead to serious consequences for the patient, such as hearing problems or deafness. Therefore, this study investigated a tapered nitinol stent (3–5 mm × 14 mm) for the human ET as a potential new permanent treatment for chronic Eustachian tube dysfunction (ETD) and thus ME ventilation disorders. The self-expanding stent was inserted unilaterally into the ET of 24 sheep with observation periods of 3, 6, and 12 months. Local tissue effects and the safety of the stent insertion were analyzed based on regular endoscopic checks, weekly tympanometry measurements, final imaging, and histological examinations. The animals showed no stent-related health restrictions. However, the individual anatomy and stenting procedure had an influence on the results. The tissue reaction in the endoscopic examinations was mild even though no concomitant antibiotics were administered. After all three monitoring periods, stented ETs had a significantly larger ET lumen than the non-stented contralateral ETs. However, tissue growth was detected in the stent. Overall, the first long-term study on an ET stent showed that the tapered ET stent could be a promising treatment option for ETD.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/bioengineering11080755
- OA Status
- gold
- Cited By
- 1
- References
- 53
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4400975501
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4400975501Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/bioengineering11080755Digital Object Identifier
- Title
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Long-Term Preclinical Evaluation of a Permanent Stent Developed for the Human Eustachian TubeWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-07-25Full publication date if available
- Authors
-
Katharina Schmitt, Malena Timm, Philipp Krüger, Niels Oppel, Alexandra Napp, Friederike Pohl, Robert Schuon, Andreas Kampmann, Lisa Kötter, Marion Bankstahl, Thomas Lenarz, Tobias Stein, Gerrit PaascheList of authors in order
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https://doi.org/10.3390/bioengineering11080755Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.3390/bioengineering11080755Direct OA link when available
- Concepts
-
Stent, Eustachian tube, Medicine, Tympanometry, Middle ear, Lumen (anatomy), Surgery, Radiology, Hearing loss, Audiometry, AudiologyTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2024: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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