Longevity through diet restriction and immunity Article Swipe

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Jeong‐Hoon Hahm , Hyo‐Deok Seo , Chang Hwa Jung , Jiyun Ahn ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.5483/bmbrep.2023-0095

The share of the population that is aging is growing rapidly. In an aging society, technologies and interventions that delay the aging process are of great interest. Dietary restriction (DR) is the most reproducible and effective nutritional intervention tested to date for delaying the aging process and prolonging the health span in animal models. Preventive effects of DR on age-related diseases have also been reported in human. In addition, highly conserved signaling pathways from small animal models to human mediate the effects of DR. Recent evidence has shown that the immune system is closely related to the effects of DR, and functions as a major mechanism of DR in healthy aging. This review discusses the effects of DR in delaying aging and preventing age-related diseases in animal, including human, and introduces the molecular mechanisms that mediate these effects. In addition, it reports scientific findings on the relationship between the immune system and DRinduced longevity. The review highlights the role of immunity as a potential mediator of the effects of DR on longevity, and provides insights into healthy aging in human. [BMB Reports 2023; 56(10): 537-544].

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Longevity Immune system Immunity Mechanism (biology) Successful aging Animal studies Healthy aging Life span Biology Human studies Mediator Gerontology Medicine Bioinformatics Immunology Endocrinology Internal medicine Philosophy Epistemology

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Type: review
Language: en
Landing Page: https://doi.org/10.5483/bmbrep.2023-0095
PDF: https://www.bmbreports.org/journal/download_pdf.php?pn=ahead&uid=1847
OA Status: gold
Cited By: 9
References: 89
Related Works: 10
OpenAlex ID: https://openalex.org/W4384341122

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OpenAlex ID: https://openalex.org/W4384341122

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DOI: https://doi.org/10.5483/bmbrep.2023-0095

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Title: Longevity through diet restriction and immunity

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Type: review

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Language: en

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Publication year: 2023

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Publication date: 2023-07-14

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Authors: Jeong‐Hoon Hahm, Hyo‐Deok Seo, Chang Hwa Jung, Jiyun Ahn

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Landing page: https://doi.org/10.5483/bmbrep.2023-0095

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PDF URL: https://www.bmbreports.org/journal/download_pdf.php?pn=ahead&uid=1847

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Concepts: Longevity, Immune system, Immunity, Mechanism (biology), Successful aging, Animal studies, Healthy aging, Life span, Biology, Human studies, Mediator, Gerontology, Medicine, Bioinformatics, Immunology, Endocrinology, Internal medicine, Philosophy, Epistemology

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Cited by: 9

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Citations by year (recent): 2025: 6, 2024: 3

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